Cys-MC-GGFG-Dxd
Based on 1 Customer Validation
Cys-MC-GGFG-Dxd is a cysteine-modified, cleavable ADC drug-linker conjugate. Cys-MC-GGFG-Dxd consists of a maleimidocaproyl-glycine-glycine-L-phenylalanine-glycine (MC-GGFG) linker and an Exatecan (HY-13631) derivative (DXd) (HY-13631D) payload. Cys-MC-GGFG-Dxd can be further conjugated to anti-HER2 IgG1κ antibody for the synthesis of antibody-drug conjugates (ADC), such as the breast cancer-targeting ADC compound Fam-trastuzumab deruxtecan-nxki (Enhertu).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.01%
- CAS 番号: 3025787-83-8
- 分子式: C55H63FN10O15S
- 分子量:1155.21
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保管条件:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Drug-Linker Conjugates for ADC アイソフォーム固有の製品をすべて表示
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生物活性
The ADC conjugate related to Cys-MC-GGFG-DXd can also be generated via enzymatic hydrolysis of ADC in human liver lysosomes, human liver S9 fractions and H358 non-small cell lung cancer cells. The proportions of mass spectrometry peak areas of Cys-MC-GGFG-DXd reach 8.11%, 35.06% and 40.01% at 48 h in human liver lysosomes, 72 h in human liver S9 fractions and 96 h in tumor cells, respectively, making it the metabolite with the highest abundance besides the parent DXd[2].
Hydrolysis analysis results of Cys-MC-GGFG-Dxd show that Dxd is mainly released inside cells and then penetrates the cell membrane to enter the incubation medium; this mechanism serves as the critical basis for the "bystander effect"[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
化学情報
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CAS 番号 3025787-83-8
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性状 Solid
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分子量 1155.21
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分子式 C55H63FN10O15S
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Color Light yellow to yellow
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SMILES
O=C(CC(SC[C@H](N)C(O)=O)C1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C(CN5C6=CC7=C(COC([C@]7(O)CC)=O)C5=O)C6=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : 50 mg/mL (43.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8656 mL | 4.3282 mL | 8.6564 mL | 21.6411 mL |
| 5 mM | 0.1731 mL | 0.8656 mL | 1.7313 mL | 4.3282 mL | |
| 10 mM | 0.0866 mL | 0.4328 mL | 0.8656 mL | 2.1641 mL | |
| 15 mM | 0.0577 mL | 0.2885 mL | 0.5771 mL | 1.4427 mL | |
| 20 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0821 mL | |
| 25 mM | 0.0346 mL | 0.1731 mL | 0.3463 mL | 0.8656 mL | |
| 30 mM | 0.0289 mL | 0.1443 mL | 0.2885 mL | 0.7214 mL | |
| 40 mM | 0.0216 mL | 0.1082 mL | 0.2164 mL | 0.5410 mL |
Cys-MC-GGFG-Dxd 関連分類
HY-176415 関連分類
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