2. Others Antibody-drug Conjugate/ADC Related
  3. Isotope-Labeled Compounds Drug-Linker Conjugates for ADC
  4. Cys-MC-GGFG-Dxd-d5 TFA

Cys-MC-GGFG-Dxd-d5 TFA  (Synonyms: Cys-MC-GGFG-Dxd-d5 TFA)

Cat. No.: HY-176415S1
SDS
Handling Instructions Technical Support

Cys-MC-GGFG-Dxd-d5 TFA (Cys-MC-GGFG-Dxd-d5 TFA) is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd-d5 TFA is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd-d5 TFA is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd-d5 TFA can be used in cancer research.

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Cys-MC-GGFG-Dxd-d5 TFA

Cys-MC-GGFG-Dxd-d5 TFA Chemical Structure

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50 mg   Get quote  
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Other Forms of Cys-MC-GGFG-Dxd-d5 TFA:

Cys-MC-GGFG-Dxd-d5 TFA Related Antibodies

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  • Purity & Documentation

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Description

Cys-MC-GGFG-Dxd-d5 TFA (Cys-MC-GGFG-Dxd-d5 TFA) is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd-d5 TFA is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd-d5 TFA is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd-d5 TFA can be used in cancer research[1][2].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Molecular Weight

1274.26

Formula

C57H59D5F4N10O17S
Unlabeled CAS
Appearance

Solid

SMILES

O=C(CC(SC[C@H](N)C(O)=O)C1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C(CN5C6=CC7=C(COC([C@]7(O)C([2H])(C([2H])([2H])[2H])[2H])=O)C5=O)C6=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (78.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7848 mL 3.9238 mL 7.8477 mL
5 mM 0.1570 mL 0.7848 mL 1.5695 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.7848 mL 3.9238 mL 7.8477 mL 19.6192 mL
5 mM 0.1570 mL 0.7848 mL 1.5695 mL 3.9238 mL
10 mM 0.0785 mL 0.3924 mL 0.7848 mL 1.9619 mL
15 mM 0.0523 mL 0.2616 mL 0.5232 mL 1.3079 mL
20 mM 0.0392 mL 0.1962 mL 0.3924 mL 0.9810 mL
25 mM 0.0314 mL 0.1570 mL 0.3139 mL 0.7848 mL
30 mM 0.0262 mL 0.1308 mL 0.2616 mL 0.6540 mL
40 mM 0.0196 mL 0.0981 mL 0.1962 mL 0.4905 mL
50 mM 0.0157 mL 0.0785 mL 0.1570 mL 0.3924 mL
60 mM 0.0131 mL 0.0654 mL 0.1308 mL 0.3270 mL
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Cys-MC-GGFG-Dxd-d5 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cys-MC-GGFG-Dxd-d5Cys-MC-GGFG-Dxd-d5Isotope-Labeled CompoundsDrug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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