Cys-MC-GGFG-Dxd-d5 TFA
Based on 1 Customer Validation
Cys-MC-GGFG-Dxd-d5 TFA (Cys-MC-GGFG-Dxd-d5 TFA) is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd-d5 TFA is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd-d5 TFA is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd-d5 TFA can be used in cancer research.
For research use only. We do not sell to patients.
- Formula: C57H59D5F4N10O17S
- Molecular Weight:1274.26
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 3025787-83-8
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Appearance Solid
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Molecular Weight 1274.26
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Formula C57H59D5F4N10O17S
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SMILES
O=C(CC(SC[C@H](N)C(O)=O)C1=O)N1CCCCCC(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(NCC(NCOCC(N[C@@H]3C4=C(CN5C6=CC7=C(COC([C@]7(O)C([2H])(C([2H])([2H])[2H])[2H])=O)C5=O)C6=NC8=CC(F)=C(C)C(CC3)=C48)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F
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Synonyms
Cys-MC-GGFG-Dxd-d5 TFA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (78.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Peng H. Perspectives on the development of antibody-drug conjugates targeting ROR1 for hematological and solid cancers. Antib Ther. 2021 Oct 15;4(4):222-227. [Content Brief]
[2]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.7848 mL | 3.9238 mL | 7.8477 mL | 19.6192 mL |
| 5 mM | 0.1570 mL | 0.7848 mL | 1.5695 mL | 3.9238 mL | |
| 10 mM | 0.0785 mL | 0.3924 mL | 0.7848 mL | 1.9619 mL | |
| 15 mM | 0.0523 mL | 0.2616 mL | 0.5232 mL | 1.3079 mL | |
| 20 mM | 0.0392 mL | 0.1962 mL | 0.3924 mL | 0.9810 mL | |
| 25 mM | 0.0314 mL | 0.1570 mL | 0.3139 mL | 0.7848 mL | |
| 30 mM | 0.0262 mL | 0.1308 mL | 0.2616 mL | 0.6540 mL | |
| 40 mM | 0.0196 mL | 0.0981 mL | 0.1962 mL | 0.4905 mL | |
| 50 mM | 0.0157 mL | 0.0785 mL | 0.1570 mL | 0.3924 mL | |
| 60 mM | 0.0131 mL | 0.0654 mL | 0.1308 mL | 0.3270 mL |
Cys-MC-GGFG-Dxd-d5 TFA Related Classifications
HY-176415S1 Related Classifications
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