IKVAVC
IKVAVC is a derivative peptide of IKVAV with an artificially added cysteine (Cys) at its C-terminus. IKVAVC retains all the biological activities of the original IKVAV, mainly acting as a neural adhesion/differentiation signaling peptide, and is equipped with an engineered linker arm that enables covalent conjugation to molecular materials. IKVAV inhibits the migration and activation of fibroblasts, downregulates the TGF-β1 signaling pathway and endoplasmic reticulum stress, and promotes nerve repair. IKVAV regulates the phenotype of macrophages, shifting them from the pro-inflammatory M1 type to the pro-reparative M2 type.
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- CAS. Nr.: 1187540-64-2
- Formel: C28H53N7O7S
- Molecular Weight:631.83
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IKVAVC is covalently conjugated to biomaterials such as hydrogels and dendrimers via chemical reactions. This functionalized material can provide bioactive signals in a long-term, stable manner, construct a bionic microenvironment conducive to nerve regeneration and angiogenesis, and shows application potential in the treatment of diseases such as spinal cord injury[1][2][3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1187540-64-2
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Molecular Weight 631.83
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Formel C28H53N7O7S
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Sequence
Ile-Lys-Val-Ala-Val-Cys
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Sequence Shortening
IKVAVC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Yin Y, et al. Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment. Biomater Sci. 2021;9(8):2887-2892. [Content Brief]
[2]. Jiang T, et al. IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation. Behav Brain Res. 2023;455:114683. [Content Brief]
[3]. Jha A, et al. Laminin-derived peptide, IKVAV, modulates macrophage phenotype through integrin mediation. Matrix Biol Plus. 2024;22:100143. Published 2024 Feb 15. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IKVAVC Related Classifications
HY-P11753 Related Classifications
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