Penetratin-Cys
Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders.
For research use only. We do not sell to patients.
- CAS No.: 393511-85-8
- Formula: C107H173N35O21S2
- Molecular Weight:2349.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Penetratin-Cys dimer (50-400 μg/mL; 24 h) exhibits strong cytotoxicity against differentiated SH-SY5Y cells at the concentration of 400 μg/mL, and shows moderate cytotoxicity against HeLa cells and undifferentiated SH-SY5Y cells across the tested concentration range[1].
Penetratin-Cys dimer (7 μM/liter; 2-24 h) efficiently enters HeLa cells and localizes to the perinuclear region associated with the Golgi apparatus after 24 h of incubation[1].
Penetratin-Cys dimer exhibits weak antibacterial activity against E. coli, M. luteus, and S. aureus, with their MIC values ranging from 8 μmol/liter to >32 μmol/liter depending on the strain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa, undifferentiated SH-SY5Y, differentiated SH-SY5Y
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Concentration:50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL
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Incubation Time:24 h
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Result:Reduced HeLa cell viability to levels below 60% at 400 μg/mL.
Reduced undifferentiated SH-SY5Y cell viability to levels similar to penetratin-PrAMP constructs at 200 μg/mL.
Reduced differentiated SH-SY5Y cell viability to ~30% at 400 μg/mL.
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Cell Line:HeLa
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Concentration:7 μM/liter
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Incubation Time:2 h, 24 h
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Result:Entered HeLa cells and aligned perinuclear in small distinct spots after 2 h.
Formed a dense cloud associated with the Golgi apparatus after 24 h.
Chemical Information
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CAS No. 393511-85-8
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Molecular Weight 2349.87
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Formula C107H173N35O21S2
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Sequence
Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys
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Sequence Shortening
RQIKIWFQNRRMKWKKC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penetratin-Cys Related Classifications
HY-P0307B Related Classifications
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