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  4. Penetratin-Cys

Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders.

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Penetratin-Cys

Penetratin-Cys Chemical Structure

CAS No. : 393511-85-8

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Other Forms of Penetratin-Cys:

Penetratin-Cys Related Antibodies

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Description

Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders[1].

In Vitro

Penetratin-Cys dimer (50-400 μg/mL; 24 h) exhibits strong cytotoxicity against differentiated SH-SY5Y cells at the concentration of 400 μg/mL, and shows moderate cytotoxicity against HeLa cells and undifferentiated SH-SY5Y cells across the tested concentration range[1].
Penetratin-Cys dimer (7 μM/liter; 2-24 h) efficiently enters HeLa cells and localizes to the perinuclear region associated with the Golgi apparatus after 24 h of incubation[1].
Penetratin-Cys dimer exhibits weak antibacterial activity against E. coli, M. luteus, and S. aureus, with their MIC values ranging from 8 μmol/liter to >32 μmol/liter depending on the strain[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Penetratin-Cys Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa, undifferentiated SH-SY5Y, differentiated SH-SY5Y
Concentration: 50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL
Incubation Time: 24 h
Result: Reduced HeLa cell viability to levels below 60% at 400 μg/mL.
Reduced undifferentiated SH-SY5Y cell viability to levels similar to penetratin-PrAMP constructs at 200 μg/mL.
Reduced differentiated SH-SY5Y cell viability to ~30% at 400 μg/mL.

Immunofluorescence[1]

Cell Line: HeLa
Concentration: 7 μM/liter
Incubation Time: 2 h, 24 h
Result: Entered HeLa cells and aligned perinuclear in small distinct spots after 2 h.
Formed a dense cloud associated with the Golgi apparatus after 24 h.
Molecular Weight

2349.87

Formula

C107H173N35O21S2
CAS No.
Sequence

Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys
Sequence Shortening

RQIKIWFQNRRMKWKKC
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Penetratin-Cys Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Penetratin-Cys393511-85-8Biochemical Assay ReagentsEscherichia coliGolgi apparatusdifferentiated neuronal cellsStaphylococcus aureusHeLa cellsproline-rich antimicrobial peptidesSH-SY5Y cellsMicrococcus luteusGram-positive bacteriabacterial infectionsInhibitorinhibitorinhibit

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