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Results for "

frogs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acyltransferase (1) Aminopeptidase (1) Androgen Receptor (1) Antibiotic (8) Apoptosis (1) Bacterial (15) Biochemical Assay Reagents (4) Bombesin Receptor (2) Dopamine Receptor (1) Endogenous Metabolite (3) Endothelin Receptor (1) Fungal (10) Herbicide (1) Histamine Receptor (1) Isotope-Labeled Compounds (1) Liposome (1) Melanocortin Receptor (2) nAChR (3) Neurokinin Receptor (1) Neuropeptide Y Receptor (1) Opioid Receptor (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) Sodium Channel (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (5) Endocrinology (4) Infection (22) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (8)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P0263

Dermaseptin	Bacterial Fungal Antibiotic	Infection
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P1629

Temporin A	Bacterial Fungal Antibiotic	Infection
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .

HY-P3443

Peanut agglutinin 1 Publications Verification PNA	Biochemical Assay Reagents	Cancer
Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions .

HY-Y1097

Monomethyl phthalate 2-(Methoxycarbonyl)benzoic acid	Endogenous Metabolite Reactive Oxygen Species (ROS)	Cancer
Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats .

HY-45509

TLB 150 Benzoate RAD150	Androgen Receptor	Neurological Disease
TLB 150 Benzoate (RAD150) is a nonsteroidal androgen receptor modulator with an IC₅₀ value of 0.13 μM. TLB 150 Benzoate spontaneously cyclizes under physiological conditions to form RAD 179, resulting in a persistent, reversible, and slow neuronal conduction blockade. TLB 150 Benzoate can be used for research on neurological diseases .

HY-P3915

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

HY-W276164

Sodium octadecyl sulfate Sodium stearyl sulfate	Biochemical Assay Reagents	Others
Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

HY-P0274

PGLa	Bacterial Antibiotic	Infection
PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-P5594

Dermaseptin-S1	Fungal	Infection
Dermaseptin-S1 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-W127668

Triethylcholine iodide	Acyltransferase	Neurological Disease
Triethylcholine iodide is a choline acetyltransferase inhibitor and a regulator of the acetylcholine synthesis pathway. Triethylcholine iodide inhibits acetylcholine synthesis in brain tissues and blocks neuromuscular and autonomic ganglionic transmission. Triethylcholine iodide exerts weak curare-like effects at extremely high concentrations. Triethylcholine iodide elevates the pentylenetetrazol seizure threshold, alters electroencephalogram patterns in Felis catus, but does not affect the maximal electroshock seizure threshold in Oryctolagus cuniculus. Triethylcholine iodide can be used in seizure-related research .

HY-137172

ETH 157	Sodium Channel	Others
ETH 157 is a neutral sodium-selective carrier. ETH 157 exhibits sufficient Na ⁺/K ⁺ selectivity and enhanced Na ⁺/Ca ²⁺ selectivity, making it suitable for the detection of extracellular Na ⁺ activity .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-W440982A

(Rac)-SOPC (Rac)-PC(18:0/18:1); (Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine	Liposome	Others
(Rac)-SOPC ((Rac)-PC(18:0/18:1)) ((Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine) is the racemate of SOPC (HY-W440982). SOPC is an asymmetrical phospholipid with saturated fatty acid (stearic acid/18:0) at sn-1 position and unsaturated fatty acid (oleic acid/18:1) at sn-2 position. SOPC can stabilize the outer segment membrane of frog rods .

HY-P3762

ANP (1-30), frog	Endothelin Receptor	Cardiovascular Disease Endocrinology
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P10265

Melanostatin, frog	Melanocortin Receptor	Others
Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC₅₀ of 60 nM .

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-129271

Deltorphin Deltorphin A; Dermenkephalin	Opioid Receptor	Others
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)

HY-N6609

Magnocurarine	nAChR	Others
Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .

HY-P1685

Ranatensin	Bombesin Receptor	Cardiovascular Disease Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-18612

MK-7725	Bombesin Receptor	Metabolic Disease
MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC₅₀ of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC₅₀ of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity .

HY-P0274A

PGLa TFA	Bacterial Antibiotic	Infection
PGLa TFA, a 21-residue peptide, is an antimicrobial peptide. PGLa TFA is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-126645

Atelopidtoxin	Sodium Channel	Cardiovascular Disease
Atelopidtoxin (zetekitoxin) is a toxin (LD₅₀=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel .

HY-101078A

(±)-Epibatidine dihydrochloride CMI 545 dihydrochloride	Dopamine Receptor	Neurological Disease
(±)-Epibatidine (CMI 545) dihydrochloride is an agonist of nicotinic with potent analgetic activity. (±)-Epibatidine (CMI 545) dihydrochloride is an alkaloid originally characterized from frog skin. (±)-Epibatidine (CMI 545) dihydrochloride have little or no activity at a variety of other central receptors, including opioid receptors, muscarinic receptors, adrenergic receptors, dopamine receptors, serotonin receptors, and gamma-aminobutyric acid receptors .

HY-W424017A

Lophophine hydrochloride	Endogenous Metabolite	Neurological Disease
Lophophine hydrochloride is the drug intermediate of anhalonine and Lophophorine (HY-119478), and can be found in Lophophora diffusa. Anhalonine causes slight sleepiness in frog. Lophophorine causes long-lasting convulsions, reflex excitability, muscle stiffness, and paralysis in rabbit and frog model .

HY-P5728

Aurein 1.1	Bacterial Antibiotic	Infection
Aurein 1.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria raniformis .

HY-P5587

Dermaseptin-S5	Fungal	Infection
Dermaseptin-S5 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5607

Bombinin	Bacterial Antibiotic Aminopeptidase	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-P5588

Dermaseptin-S4	Fungal	Infection
Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5590

Dermaseptin-S3	Fungal	Infection
Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5593

Dermaseptin-S2	Fungal	Infection
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5725

Aurein 2.1	Bacterial Antibiotic	Infection
Aurein 2.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria aurea and Litoria raniformis .

HY-P5585

Dermaseptin-B4	Bacterial	Infection
Dermaseptin-B4 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .

HY-P0250

Kassinin	Neurokinin Receptor	Neurological Disease Endocrinology
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P0263A

Dermaseptin TFA	Bacterial Fungal	Infection
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P5638

FLGFVGQALNALLGKL-NH2	Bacterial	Infection
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureus ATCC 29213 (MIC=32 μM) .

HY-167657

Tizolemide	Sodium Channel	Cardiovascular Disease
Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin .

HY-158702

5-HTQ chloride	5-HT Receptor	Neurological Disease
5-HTQ chloride is an indole alkaloid that can be isolated from the skin secretions of the Australian golden bell frog Litoria aurea. 5-HTQ chloride is also a full agonist of the 5-HT receptor .

HY-P5690

Distinctin	Bacterial	Infection
Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .

HY-P5937

Caerin 1.1 TFA	Apoptosis	Cancer
Caerin 1.1 TFA is a host defense peptide isolated from the glandular secretions of the Australian tree frog Litoria. Caerin 1.1 TFA inhibits HeLa cell proliferation and mediates apoptosis. Caerin 1.1 TFA may enhance adaptive T cell immune responses .

HY-Y1097R

Monomethyl phthalate (Standard) 2-(Methoxycarbonyl)benzoic acid (Standard)	Reference Standards Endogenous Metabolite	Cancer
Monomethyl phthalate (Standard) is the analytical standard of Monomethyl phthalate. This product is intended for research and analytical applications. Monomethyl phthalate is an orally active metabolite of phthalic acid. Monomethyl phthalate, as a urine biomarker after exposure to phthalate, can be used as a detection indicator for thyroid cancer and benign nodules. Monomethyl phthalate reduces the survival rate of young frogs. Monomethyl phthalate induces oxidative damage to red blood cells in rats.

HY-P2019

Levitide	Neuropeptide Y Receptor	Neurological Disease
Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .

HY-W033687

Triclopyr triethylamine	Herbicide	Others
Triclopyr triethylamine is a herbicide. Triclopyr triethylamine causes lethargy in metamorphic northern red-legged frogs during exposure, and delays the completion time of metamorphosis in northern red-legged frogs. Triclopyr triethylamine is used to control broadleaf emergent aquatic weeds, such as the invasive species Lythrum salicaria .

HY-N6609B

Magnocurarine chloride	nAChR	Cardiovascular Disease
Magnocurarine chloride is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine chloride exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine chloride does not affect the spinal multineuronal reflex in frogs. Magnocurarine chloride exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .

HY-P3171

Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

HY-175991S

Sodium octadecyl sulfate-d37 Sodium stearyl sulfate sulfate-d₃₇	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Sodium octadecyl sulfate-d₃₇ (Sodium stearyl sulfate-d₃₇) is the deuterium labeled Sodium octadecyl sulfate (HY-W276164). Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

HY-N16985

Taraxasteryl palmitate	Others	Inflammation/Immunology
Taraxasteryl palmitate is a taraxasterol-type triterpene ester compound with antiemetic activity. Intralymphatic injection of 30 mg/kg and 100 mg/kg Taraxasteryl palmitate significantly inhibited vomiting in a copper sulfate-induced frog vomiting model, with vomiting latency extension rates of 116.9% and 120.0%, respectively. Taraxasteryl palmitate exerts its anti-reflex vomiting activity by prolonging the vomiting latency. Taraxasteryl palmitate can be used in the study of vomiting-related diseases (especially reflex vomiting). Taraxasteryl palmitate can be naturally extracted from the flowers of Inula linariaefolia .

HY-W795736

(+)-Vesamicol (+)-AH5183	nAChR	Neurological Disease
(+)-Vesamicol ((+)-AH5183) is an acetylcholine vesicular transport system inhibitor. (+)-Vesamicol blocks acetylcholine storage and uptake by synaptic vesicles, reducing transmitter availability for neuromuscular junction release. (+)-Vesamicol acts as a neuromuscular blocking agent, producing frequency-dependent neuromuscular block in rat hemidiaphragm preparations .

Cat. No.	Product Name	Type

HY-P3443

Peanut agglutinin

1 Publications Verification

PNA

Biochemical Assay Reagents

Peanut agglutinin (PNA) is a carbohydrate-recognition protein that binds competitively and irreversibly to cell-surface β-D-Gal (1-3)-GalNAc, and this binding can be inhibited by D-galactose and asialofetuin. Peanut agglutinin recognizes exposed glycoepitopes and reflects the glycosylation status of cells. Peanut agglutinin can label glycoconjugates at neuromuscular junctions to safely visualize synaptic structures. Peanut agglutinin can be used to synthesize dyes to distinguish between normal and tumor tissues. Peanut agglutinin provides support for research on leukemia, Burkitt's tumors, and cutaneous squamous lesions .

HY-W276164

Sodium octadecyl sulfate

Sodium stearyl sulfate

Biochemical Assay Reagents

Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

HY-W127668

Triethylcholine iodide

Biochemical Assay Reagents

Triethylcholine iodide is a choline acetyltransferase inhibitor and a regulator of the acetylcholine synthesis pathway. Triethylcholine iodide inhibits acetylcholine synthesis in brain tissues and blocks neuromuscular and autonomic ganglionic transmission. Triethylcholine iodide exerts weak curare-like effects at extremely high concentrations. Triethylcholine iodide elevates the pentylenetetrazol seizure threshold, alters electroencephalogram patterns in Felis catus, but does not affect the maximal electroshock seizure threshold in Oryctolagus cuniculus. Triethylcholine iodide can be used in seizure-related research .

Cat. No.	Product Name	Target	Research Area

HY-P0270

Magainin 2 Magainin II	Bacterial Antibiotic Fungal	Infection
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P0263

Dermaseptin	Bacterial Fungal Antibiotic	Infection
Dermaseptin, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P1629

Temporin A	Bacterial Fungal Antibiotic	Infection
Temporin A is a short alpha-helical antimicrobial peptide isolated from the skin of the frog Rana temporaria. Temporin A is effective against a broad spectrum of Gram-positive bacteria. Temporin A interacts directly with the cell membrane of the microorganism and it is non-toxic to erythrocytes at concentrations that are antimicrobial. Temporin A also has antifungal activities (against yeast-like Candida albicans) .

HY-P3915

Esculentin 1A	Bacterial	Infection
Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity .

HY-P0274

PGLa	Bacterial Antibiotic	Infection
PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-P5594

Dermaseptin-S1	Fungal	Infection
Dermaseptin-S1 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P3645

(Nle4)-α-MSH	Melanocortin Receptor	Others
(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment .

HY-P3762

ANP (1-30), frog	Endothelin Receptor	Cardiovascular Disease Endocrinology
ANP (1-30), frog is a peptide fragment of atrial natriuretic peptide derived from frog. ANP (1-30), frog has natriuretic, diuretic, and vasorelaxant effects.

HY-P4816

Pseudin-2	Bacterial Fungal	Infection Inflammation/Immunology
Pseudin-2, an AMP thast could be isolated from the skin of the South American paradoxical frog Pseudis paradoxa, exert a potent growth inhibitory effect against Gram-negative bacteria .

HY-P2706

Granuliberin R	Histamine Receptor	Endocrinology
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine .

HY-P10265

Melanostatin, frog	Melanocortin Receptor	Others
Melanostatin, frog is an inhibitor for α-melanocyte-stimulating hormone (α-MSH) release, with an IC₅₀ of 60 nM .

HY-P5724

Nv-CATH	Bacterial	Infection
Nv-CATH is an antibacterial peptide of frog origin. Nv-CATH has broad-spectrum antibacterial activity against gram-positive and gram-negative bacteria. Nv-CATH significantly protects mice from fatal infections caused by Staphylococcus aureus. Nv-CATH protects mice from bacterial infection through antimicrobial immunoregulatory duality .

HY-P5972

GRP20–29, frog	Peptides	Cancer
GRP20–29, frog is a 10-amino acid antigen peptide that can be isolated from Xenopus .

HY-129271

Deltorphin Deltorphin A; Dermenkephalin	Opioid Receptor	Others
Deltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)

HY-P1685

Ranatensin	Bombesin Receptor	Cardiovascular Disease Endocrinology
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715) .

HY-P1343

Frog 26RFa	Peptides	Others
Frog 26RFa is a neuropeptide that can be isolated from frog brain. Frog 26RFa has pro-oxygen activity .

HY-P0274A

PGLa TFA	Bacterial Antibiotic	Infection
PGLa TFA, a 21-residue peptide, is an antimicrobial peptide. PGLa TFA is a member of the magainin family of antibiotic peptides found in frog skin and its secretions .

HY-P5583

Dermaseptin-B9	Peptides	Infection
Dermaseptin-B9 is an antimicrobial peptide isolated from frogs of the Phyllomedusinae subfamily .

HY-P5728

Aurein 1.1	Bacterial Antibiotic	Infection
Aurein 1.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria raniformis .

HY-P5587

Dermaseptin-S5	Fungal	Infection
Dermaseptin-S5 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5607

Bombinin	Bacterial Antibiotic Aminopeptidase	Infection
Bombinin is an antimicrobial peptide derived from frog Bombina variegata. Bombinin has a protective effect on aminopeptidase .

HY-P5588

Dermaseptin-S4	Fungal	Infection
Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5590

Dermaseptin-S3	Fungal	Infection
Dermaseptin-S3 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5593

Dermaseptin-S2	Fungal	Infection
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi .

HY-P5725

Aurein 2.1	Bacterial Antibiotic	Infection
Aurein 2.1 is an antibiotic peptide that can be found in the Australian Bell Frogs Litoria aurea and Litoria raniformis .

HY-P5585

Dermaseptin-B4	Bacterial	Infection
Dermaseptin-B4 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .

HY-P0250

Kassinin	Neurokinin Receptor	Neurological Disease Endocrinology
Kassinin is a peptide derived from the Kassina frog. It belongs to tachykinin family of neuropeptides. It is secreted as a defense response, and is involved in neuropeptide signalling.

HY-P0263A

Dermaseptin TFA	Bacterial Fungal	Infection
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .

HY-P5638

FLGFVGQALNALLGKL-NH2	Bacterial	Infection
FLGFVGQALNALLGKL-NH2 is an antimicrobial peptide of frog origin. FLGFVGQALNALLGKL-NH2 has activity against Staphylococcus aureus ATCC 29213 (MIC=32 μM) .

HY-P5690

Distinctin	Bacterial	Infection
Distinctin is an antimicrobial peptide. Distinctin can be isolated from frog skin. Distinctin has antibacterial activity against E. faecalis, P. aeruginosa, S. aureus and E. coli (MIC: 14.5, 28.0, 28.0, 14.5 μM) .

HY-P5937

Caerin 1.1 TFA	Apoptosis	Cancer
Caerin 1.1 TFA is a host defense peptide isolated from the glandular secretions of the Australian tree frog Litoria. Caerin 1.1 TFA inhibits HeLa cell proliferation and mediates apoptosis. Caerin 1.1 TFA may enhance adaptive T cell immune responses .

HY-P2019

Levitide	Neuropeptide Y Receptor	Neurological Disease
Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus .

HY-P3171

Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)	Biochemical Assay Reagents	Others
Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .

HY-P5586

Dermaseptin-B5	Peptides	Infection
Dermaseptin-B5 is an antimicrobial peptide derived from the skin secretions of the South American frog Phyllomedusa bicolor .

Cat. No.	Product Name	Chemical Structure

HY-175991S

Sodium octadecyl sulfate-d37

Sodium octadecyl sulfate-d₃₇ (Sodium stearyl sulfate-d₃₇) is the deuterium labeled Sodium octadecyl sulfate (HY-W276164). Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD₅₀ greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems .

Cat. No.	Product Name		Classification

HY-W440982A

(Rac)-SOPC (Rac)-PC(18:0/18:1); (Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine		Phospholipids
(Rac)-SOPC ((Rac)-PC(18:0/18:1)) ((Rac)-2-Oleoyl-1-stearoyl-sn-glycero-3-phosphocholine) is the racemate of SOPC (HY-W440982). SOPC is an asymmetrical phospholipid with saturated fatty acid (stearic acid/18:0) at sn-1 position and unsaturated fatty acid (oleic acid/18:1) at sn-2 position. SOPC can stabilize the outer segment membrane of frog rods .

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