Granuliberin R
Granuliberin R is a new mast cell degranulating peptide comes from amphibian, can be isolated from the skin of frog Rana rugosa. Granuliberin R is a dodecapeptide, can act on rat peritoneal mast cell to liberate granules and release histamine.
For research use only. We do not sell to patients.
- CAS No.: 64704-41-2
- Formula: C69H103N19O14
- Molecular Weight:1422.68
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Granuliberin R (10 μg/mL) does not alter the release of catecholamines and adenine nucleotides from cultured adrenal chromaffin cells, while the Mastoparan (10 μg/mL) increases both of them[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 64704-41-2
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Molecular Weight 1422.68
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Formula C69H103N19O14
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Sequence
Phe-Gly-Phe-Leu-Pro-Ile-Tyr-Arg-Arg-Pro-Ala-Ser-NH2
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Sequence Shortening
FGFLPIYRRPAS-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Nakajima T, et al. A new mast cell degranulating peptide, granuliberin-R, in the frog (Rana rugosa) skin. Chem Pharm Bull (Tokyo). 1977 Sep;25(9):2464-5. [Content Brief]
[2]. Yasuhara T, et al. The studies on the active peptide in the skin of Rana rugosa. II. The structure of ranatensin-R, the new ranatensin analogue, and granuliberin-R, the new mast cell degranulating peptide. Chem Pharm Bull (Tokyo). 1979 Feb;27(2):492-8. [Content Brief]
[3]. Vitale N, et al. Exocytosis in chromaffin cells: evidence for a MgATP-independent step that requires a pertussis toxin-sensitive GTP-binding protein. Biochem J. 1994 May 15;300 ( Pt 1)(Pt 1):217-27. [Content Brief]
[4]. Kozakiewicz M, et al. Modulation of the mitotic activity and population of the mast cells in the oral mucosa by substance P. Cell Mol Biol Lett. 2003;8(3):727-34. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Granuliberin R Related Classifications
HY-P2706 Related Classifications
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