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United States

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製品番号: HY-18612

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MK-7725

MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3). MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC₅₀ of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC₅₀ of 22 nM (105% agonistic). MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1034152-93-6
分子式: C₂₅H₁₉F₆N₅O₅S
分子量:615.50

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

MK-7725 構造式

CAS 番号: 1034152-93-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	3.6 nM Compound: 1, MK-7725	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	[PMID: 22494842]
CHO	IC₅₀	3.6 nM Compound: 14, MK-7725	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	[PMID: 24900461]
CHO-K1	EC₅₀	1.4 nM Compound: 2, MK-7725	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	130 nM Compound: 1b, MK-7725	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]
CHO-K1	EC₅₀	22 nM Compound: 2, MK-7725	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	[PMID: 24412111]
CHO-K1	EC₅₀	73 nM Compound: 1b, MK-7725	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	[PMID: 25497965]

化学情報

CAS 番号 1034152-93-6
分子量 615.50
分子式 C₂₅H₁₉F₆N₅O₅S
SMILES

O=S(C1=CC=C(C=C1)OC(F)(F)F)(N2C3=C(C4=NOC(C(C)(C)O)=N4)C=CC=C3NC5=NC(C(F)(F)F)=CC=C5C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Chobanian HR, et al. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2012 Jan 21;3(3):252-6. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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