Ranatensin
Ranatensin is a undecapeptide and a Bombesin Receptor angonist, can be isolated from amphibian skin, such as the frog, Rana pipiens. Ranatensin could maintain the dynamic balance of animal blood pressure, without cross-tachyphylaxis with Angiotensin amide (HY-P2212),Bradykinin (HY-P0206), or Norepinephrine (HY-13715).
For research use only. We do not sell to patients.
- CAS No.: 29451-71-6
- Formula: C61H84N16O13S
- Molecular Weight:1281.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Ranatensin (0.3 nM; 30 min) induces amylase release by various pancreatic secretagogues[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Ranatensin (10-50 μg/mL, 0.1-1 mL; i.v.; single dose) also lowers blood pressure in the monkey, being as potent as Eledoisin (HY-P0006). It show a direct peripheral action on vascular smooth muscle[2].
Ranatensin (10-50 μg/mL, 0.005-0.1 mL; i.v.; single dose) has a variable effect based on the basal level of blood pressure in the rat that shows antihypertensive efffect during high level and raises blood pressure when level is low, in part due to the release of noradrenaline from peripheral sympathetic nerve endings[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 29451-71-6
-
Molecular Weight 1281.48
-
Formula C61H84N16O13S
-
Sequence Shortening
Glp-VPQWAVGHFM-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jensen RT, et al. A synthetic peptide that is a bombesin receptor antagonist. Nature. 1984 May 3-9;309(5963):61-3. [Content Brief]
[2]. Geller RG, et al. The action of ranatensin, a new polypeptide from amphibian skin, on the blood pressure of experimental animals. Br J Pharmacol. 1970 Dec;40(4):605-16. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ranatensin Related Classifications
HY-P1685 Related Classifications
Powered by Bioz