1. Peptides

Eledoisin (Synonyms: Eledone peptide)

Cat. No.: HY-P0006 Purity: 99.53%
Handling Instructions

Eledoisin is a specific agonist of NK2 and NK3 receptors. Sequence: {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Eledoisin Chemical Structure

Eledoisin Chemical Structure

CAS No. : 69-25-0

Size Price Stock Quantity
10 mM * 1 mL in Water USD 141 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 108 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 216 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Eledoisin is a specific agonist of NK2 and NK3 receptors. Sequence: {Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2.

IC50 & Target

NK2 and NK3 receptors[1].

In Vitro

Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].

In Vivo

Eledoisin (0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].

Solvent & Solubility
In Vitro: 

H2O : 18.15 mg/mL (15.27 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8415 mL 4.2073 mL 8.4147 mL
5 mM 0.1683 mL 0.8415 mL 1.6829 mL
10 mM 0.0841 mL 0.4207 mL 0.8415 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

1188.40

Formula

C₅₄H₈₅N₁₃O₁₅S

CAS No.

69-25-0

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
Eledoisin
Cat. No.:
HY-P0006
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Eledoisin

Cat. No.: HY-P0006