Eledoisin
Based on 1 Customer Validation
Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.
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- Pureté: 99.06%
- CAS No.: 69-25-0
- Formule: C54H85N13O15S
- Masse moléculaire:1188.40
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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NK2R |
NK3R |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.22 nM
Compound: 5a
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Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM
Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM
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[PMID: 23473945] |
| CHO | EC50 |
5.7 nM
Compound: eledoisin
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Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells
Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells
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[PMID: 16950620] |
| CHO | EC50 |
6.6 nM
Compound: eledoisin
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Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation
Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation
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[PMID: 16950617] |
| CHO | IC50 |
96 nM
Compound: 5a
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Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis
Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis
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[PMID: 23473945] |
Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 69-25-0
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Appearance Solid
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Masse moléculaire 1188.40
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Formule C54H85N13O15S
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Color White to off-white
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Synonyms
Eledone peptide
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Sequence
{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
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Sequence Shortening
{Glp}-PSKDAFIGLM-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
H2O : 18.15 mg/mL (15.27 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.8415 mL | 4.2073 mL | 8.4147 mL | 21.0367 mL |
| 5 mM | 0.1683 mL | 0.8415 mL | 1.6829 mL | 4.2073 mL | |
| 10 mM | 0.0841 mL | 0.4207 mL | 0.8415 mL | 2.1037 mL | |
| 15 mM | 0.0561 mL | 0.2805 mL | 0.5610 mL | 1.4024 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Eledoisin Related Classifications
HY-P0006 Related Classifications
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