2. GPCR/G Protein Neuronal Signaling
  3. Neurokinin Receptor
  4. Eledoisin

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

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Eledoisin

Eledoisin Chemical Structure

CAS No. : 69-25-0

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Eledoisin Related Antibodies

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Description

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

IC50 & Target

NK2R

 

NK3R

 

Cellular Effect
Cell Line Type Value Description References
CHO EC50
0.22 nM
Compound: 5a
Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM
Agonist activity at NK3R (unknown origin) transfected in CHO cells assessed as calcium influx at 10 mM
[PMID: 23473945]
CHO EC50
5.7 nM
Compound: eledoisin
Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells
Activity at human NK3 receptor assessed as stimulation of inositol phosphate generation in CHO cells
[PMID: 16950620]
CHO EC50
6.6 nM
Compound: eledoisin
Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation
Activity at human NK3 receptor expressed in CHO cells assessed as increase in inositol phosphate generation
[PMID: 16950617]
CHO IC50
96 nM
Compound: 5a
Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis
Displacement of ([125I]-His3, MePhe7)-NKB from NK3R (unknown origin) transfected in CHO cells by gamma counting analysis
[PMID: 23473945]
In Vitro

Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Eledoisin Related Antibodies
In Vivo

Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

1188.40

Formula

C54H85N13O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
Sequence Shortening

{Glp}-PSKDAFIGLM-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 18.15 mg/mL (15.27 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8415 mL 4.2073 mL 8.4147 mL
5 mM 0.1683 mL 0.8415 mL 1.6829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8415 mL 4.2073 mL 8.4147 mL 21.0367 mL
5 mM 0.1683 mL 0.8415 mL 1.6829 mL 4.2073 mL
10 mM 0.0841 mL 0.4207 mL 0.8415 mL 2.1037 mL
15 mM 0.0561 mL 0.2805 mL 0.5610 mL 1.4024 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Eledoisin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Eledoisin69-25-0Eledone peptideNeurokinin ReceptorNK receptorTachykinin receptorInhibitorinhibitorinhibit

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