TLB 150 Benzoate
Based on 1 Customer Validation
TLB 150 Benzoate (RAD150) is a nonsteroidal androgen receptor modulator with an IC50 value of 0.13 μM. TLB 150 Benzoate spontaneously cyclizes under physiological conditions to form RAD 179, resulting in a persistent, reversible, and slow neuronal conduction blockade. TLB 150 Benzoate can be used for research on neurological diseases.
For research use only. We do not sell to patients.
- Purity: 98.3%
- CAS No.: 1208070-53-4
- Formula: C27H20ClN5O3
- Molecular Weight:497.93
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
TLB 150 Benzoate (5 mM) cyclizes to form RAD 179 in a pH 7.4 buffered ethanol solution at 37°C with a half-life of 40 minutes[1].
TLB 150 Benzoate (5 mM; 20 min) is taken up by intact Rana pipiens frog sciatic nerves, cyclizes to form RAD 179[1].
TLB 150 Benzoate (5 mM; 20 min) produces a slowly reversible local anesthetic block of intact Rana pipiens frog sciatic nerves, with 50% recovery of action potential amplitude occurring approximately seven hours after washing[1].
TLB 150 Benzoate (0.1 mM) forms RAD 179 inside rabbit and rat erythrocytes, which undergoes slow first-order efflux with half-lives of 9 h and 4.4 h respectively, and depolarization of rat erythrocyte membranes with potassium chloride increases efflux rate to a half-life of 2.7 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 |
|---|---|---|---|
| Rabbit[2] | 2.5 mg/kg | i.v. | 1.2 h |
TLB 150 Benzoate (2.5 mg/kg; i.v.; single dose) cyclizes to RAD 179 in rabbit blood in vivo, with RAD 150 eliminated rapidly and RAD 179 eliminated slowly[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:White rabbits (either sex, 2.5-4.5 kg)[2]
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Dosage:2.5 mg/kg
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Administration:i.v.; single dose
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Result:Exceeded RAD 179 concentration in blood during the first 30 minutes post-injection, then rapidly decreased.
Reached near the limit of detection in blood by 4 hours.
Disappeared from plasma with a half-life of 1.2 hours.
Disappeared from erythrocytes at the same rate as in plasma.
Chemical Information
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CAS No. 1208070-53-4
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Appearance Solid
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Molecular Weight 497.93
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Formula C27H20ClN5O3
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Color White to off-white
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SMILES
N#CC1=CC=C(N[C@@H](C2=NN=C(C3=CC=C(C#N)C=C3)O2)[C@@H](OC(C4=CC=CC=C4)=O)C)C(C)=C1Cl
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Synonyms
RAD150
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLB 150 Benzoate Related Classifications
HY-45509 Related Classifications
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