1208070-53-4
Chemical Structure
TLB 150 Benzoate
Synonym(s): RAD150
- CAS No.: 1208070-53-4
- Formula:C27H20ClN5O3
- Molecular Weight:497.93
IUPAC Name: (1R,2S)-1-((3-chloro-4-cyano-2-methylphenyl)amino)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)propan-2-yl benzoate
InChIKey: NQUKIBBKKLFEQU-BXKMTCNYSA-N
SMILES: N#CC1=CC=C(N[C@@H](C2=NN=C(C3=CC=C(C#N)C=C3)O2)[C@@H](OC(C4=CC=CC=C4)=O)C)C(C)=C1Cl
Biological Activity: TLB 150 Benzoate (RAD150) is a nonsteroidal androgen receptor modulator with an IC50 value of 0.13 μM. TLB 150 Benzoate spontaneously cyclizes under physiological conditions to form RAD 179, resulting in a persistent, reversible, and slow neuronal conduction blockade. TLB 150 Benzoate can be used for research on neurological diseases[1][2][3].
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TLB 150 Benzoate | 98.3% | TLB 150 Benzoate (RAD150) is a nonsteroidal androgen receptor modulator with an IC50 value of 0.13 μM. TLB 150 Benzoate spontaneously cyclizes under physiological conditions to form RAD 179, resulting in a persistent, reversible, and slow neuronal conduction blockade. TLB 150 Benzoate can be used for research on neurological diseases. | ||||||||||||||||||||
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References
- [1]. Ross S, et al. Cyclization of three n-ω-haloalkyl-n-methylaminoaceto-2, 6-xyilidide derivatives in relation to their local anesthetic effect in vitro and in vivo. J. Pharmacol. Exp. Ther. 182(2):351-361.
- [2]. Ross SB, et al. Pharmacokinetics of haloalkylamines: cyclization and distribution in blood in vitro and in vivo. J Pharm Pharmacol. 1975;27(5):322-328. [Content Brief]
- [3]. Miller CP. Selective androgen receptor modulators. United States, US20100041721. 2010-02-18.
