Sodium octadecyl sulfate
Based on 1 Customer Validation
Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD50 greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 1120-04-3
- Formula: C18H37NaO4S
- Molecular Weight:372.54
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| WEHI-164 | IC50 |
410 μg/mL
Compound: 2
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Antiproliferative activity against mouse WEHI164 cells assessed as cell viability after 96 hrs by MTT assay
Antiproliferative activity against mouse WEHI164 cells assessed as cell viability after 96 hrs by MTT assay
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[PMID: 11430005] |
Sodium octadecyl sulfate (1:100,000-1:100; until muscle fatigue) does not alter the nerve conduction of isolated frog sciatic nerves[1].
Sodium octadecyl sulfate (1:100) irreversibly elevates the contraction baseline of isolated frog gastrocnemius muscles without reducing the response threshold[1].
Sodium octadecyl sulfate (1:100; 5 min) enhances the activity of isolated rat intestinal smooth muscle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Sodium octadecyl sulfate (>3.0 Gm/kg; p.o.) has an oral LD50 greater than 3.0 Gm/kg in albino rats, inducing lethal gastrointestinal damage within 24 hours[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino mice (mixed gender, weight 18-32 Gm)[1]
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Dosage:477 mg/kg
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Administration:i.p.
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Result:Determined an intraperitoneal LD50 of 477 mg/kg.
Induced initial increased activity followed by graded depression, prostration, and death (most deaths 12-18 hours post-injection).
Revealed swollen, deep red intestines with blood in the lumen, slight peritoneal hemorrhages, and severe dilation of mesenteric and intestinal blood vessels with visceral swelling upon autopsy.
Chemical Information
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CAS No. 1120-04-3
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Appearance Solid
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Molecular Weight 372.54
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Formula C18H37NaO4S
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCOS(=O)(O[Na])=O
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Synonyms
Sodium stearyl sulfate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 16.67 mg/mL (44.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6843 mL | 13.4214 mL | 26.8428 mL | 67.1069 mL |
| 5 mM | 0.5369 mL | 2.6843 mL | 5.3686 mL | 13.4214 mL | |
| 10 mM | 0.2684 mL | 1.3421 mL | 2.6843 mL | 6.7107 mL | |
| 15 mM | 0.1790 mL | 0.8948 mL | 1.7895 mL | 4.4738 mL | |
| 20 mM | 0.1342 mL | 0.6711 mL | 1.3421 mL | 3.3553 mL | |
| 25 mM | 0.1074 mL | 0.5369 mL | 1.0737 mL | 2.6843 mL | |
| 30 mM | 0.0895 mL | 0.4474 mL | 0.8948 mL | 2.2369 mL | |
| 40 mM | 0.0671 mL | 0.3355 mL | 0.6711 mL | 1.6777 mL |
Sodium octadecyl sulfate Related Classifications
HY-W276164 Related Classifications
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