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  4. Sodium octadecyl sulfate

Sodium octadecyl sulfate  (Synonyms: Sodium stearyl sulfate)

Cat. No.: HY-W276164 Purity: 99.86%
COA
SDS
Handling Instructions Technical Support

Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD50 greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems.

For research use only. We do not sell to patients.

Sodium octadecyl sulfate

Sodium octadecyl sulfate Chemical Structure

CAS No. : 1120-04-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sodium octadecyl sulfate:

Sodium octadecyl sulfate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Sodium octadecyl sulfate (Sodium stearyl sulfate) is a long-chain alkyl sodium sulfate that functions as an emulsifier, crosslinking agent, and regulator. Sodium octadecyl sulfate has high safety, with a LD50 greater than 3.00 Gm./Kg for both intraperitoneal injection in mice and oral administration in rats. Sodium octadecyl sulfate enhances continuous contraction of the gastrocnemius muscle in frogs and boosts intestinal smooth muscle activity in albino rats. However, Sodium octadecyl sulfate exerts no significant effect on isolated tortoise myocardium and does not alter the conduction function of frog sciatic nerves. Sodium octadecyl sulfate can also be used to coat the surface of starch aggregates, promote crosslinking and increase aggregate size through hydrophobic and electrostatic interactions, and further form a coexistent B-V type crystalline structure with acid-hydrolyzed gelatinized starch, thereby effectively modifying the structure and surface properties of high-starch systems[1][2].

Cellular Effect
Cell Line Type Value Description References
WEHI-164 IC50
410 μg/mL
Compound: 2
Antiproliferative activity against mouse WEHI164 cells assessed as cell viability after 96 hrs by MTT assay
Antiproliferative activity against mouse WEHI164 cells assessed as cell viability after 96 hrs by MTT assay
[PMID: 11430005]
In Vitro

Sodium octadecyl sulfate (1:100,000-1:100; until muscle fatigue) does not alter the nerve conduction of isolated frog sciatic nerves[1].
Sodium octadecyl sulfate (1:100) irreversibly elevates the contraction baseline of isolated frog gastrocnemius muscles without reducing the response threshold[1].
Sodium octadecyl sulfate (1:100; 5 min) enhances the activity of isolated rat intestinal smooth muscle[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium octadecyl sulfate Related Antibodies
In Vivo

Sodium octadecyl sulfate (477 mg/kg; i.p.) has an intraperitoneal LD50 of 477 mg/kg in mixed-gender albino mice, inducing lethal gastrointestinal and visceral damage within 24 hours[1].
Sodium octadecyl sulfate (>3.0 Gm/kg; p.o.) has an oral LD50 greater than 3.0 Gm/kg in albino rats, inducing lethal gastrointestinal damage within 24 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino mice (mixed gender, weight 18-32 Gm)[1]
Dosage: 477 mg/kg
Administration: i.p.
Result: Determined an intraperitoneal LD50 of 477 mg/kg.
Induced initial increased activity followed by graded depression, prostration, and death (most deaths 12-18 hours post-injection).
Revealed swollen, deep red intestines with blood in the lumen, slight peritoneal hemorrhages, and severe dilation of mesenteric and intestinal blood vessels with visceral swelling upon autopsy.
Molecular Weight

372.54

Formula

C18H37NaO4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCCCCCCCCCOS(=O)(O[Na])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (44.75 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6843 mL 13.4214 mL 26.8428 mL
5 mM 0.5369 mL 2.6843 mL 5.3686 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 1.67 mg/mL (4.48 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.67 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.7 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.86%

SDS (394 KB)

COA (239 KB) HNMR (118 KB) RP-HPLC (196 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6843 mL 13.4214 mL 26.8428 mL 67.1069 mL
5 mM 0.5369 mL 2.6843 mL 5.3686 mL 13.4214 mL
10 mM 0.2684 mL 1.3421 mL 2.6843 mL 6.7107 mL
15 mM 0.1790 mL 0.8948 mL 1.7895 mL 4.4738 mL
20 mM 0.1342 mL 0.6711 mL 1.3421 mL 3.3553 mL
25 mM 0.1074 mL 0.5369 mL 1.0737 mL 2.6843 mL
30 mM 0.0895 mL 0.4474 mL 0.8948 mL 2.2369 mL
40 mM 0.0671 mL 0.3355 mL 0.6711 mL 1.6777 mL
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Sodium octadecyl sulfate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sodium octadecyl1120-04-3Sodium stearylBiochemical Assay Reagentsfrog gastrocnemius musclesturtle cardiac muscleacid-thermal pretreated corn starchmicestarchfrog sciatic nerveamylosefrog gastrocnemius muscleratsalbino rat smooth muscleInhibitorinhibitorinhibit

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