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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
human epidermoid
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "human epidermoid" in MCE Product Catalog:
Research Areas:
PD 174265 is a highly selective, reversible EGFR/ErbB2 tyrosine kinase inhibitor (IC50=0.45 nM) and cell differentiation inducer. By blocking receptor autophosphorylation and the downstream ERK signaling pathway (with an IC50 of 0.45 μM for full-length ERK), PD 174265 effectively inhibits tumor growth and exhibits antitumor activity without obvious toxicity in in vivo models. PD 174265 drives oligodendrocyte precursor cells to switch from a proliferative state to a differentiated state, significantly upregulates the expression of myelin proteins such as CNP, PLP and MBP, and induces neurite branching. PD 174265 shows no inhibitory effect on other kinases including insulin, PDGF and basic FGF receptors, and serves as a crucial tool molecule for investigating the treatment of human epidermoid carcinoma and the mechanism of myelin repair in multiple sclerosis .
Cat. No.: HY-W017424
CAS No.: 136-95-8
Target:
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2-Aminobenzothiazole acts as a caspase 3/7 activator, an anticancer cytotoxic agent, and also exhibits neurotoxicity. 2-Aminobenzothiazole drives the apoptotic pathway by activating caspase 3/7, induces mitochondrial inner membrane depolarization, and triggers both early and late apoptosis via a caspase-dependent pathway. In zebrafish models, 2-Aminobenzothiazole induces oxidative damage in brain tissues and inhibits genes related to GABA and 5-HT synthesis pathways. Long-term exposure to 2-Aminobenzothiazole impairs motor ability, social behavior, anxiety-like state and cognitive function. 2-Aminobenzothiazole can be used in studies of human laryngeal carcinoma and related neurotoxicity .
Cat. No.: HY-W278867
CAS No.: 21956-56-9
Synonyms: trans-Pinosylvin dimethyl ether
Category:
Stilbenes Leguminosae Plants Disease Research Fields Inflammation/Immunology Astragalus membranaceus (Fisch.) Bunge
Target:
trans-3,5-Dimethoxystilbene (trans-Pinosylvin dimethyl ether) is a natural stilbenoid metabolite. trans-3,5-Dimethoxystilbene acts as an acetylcholinesterase inhibitor with a IC50 of 9 μM against Electrophorus electricus acetylcholinesterase. trans-3,5-Dimethoxystilbene binds to acetylcholinesterase and blocks acetylcholine hydrolysis, thereby increasing acetylcholine levels in the cholinergic synaptic cleft. trans-3,5-Dimethoxystilbene can be used in the research of neurodegenerative diseases such as Alzheimer's disease .
Cat. No.: HY-N8420
CAS No.: 21796-15-6
Category:
Infection Alkaloids Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids Menispermaceae Menispermum dauricum
Target:
(–)-Cryptopleurine is an alkaloid that has been found in Lauraceae and has diverse biological activities. It inhibits the growth of human A375 melanoma, A431 epidermoid carcinoma, A549 lung, MES-SA uterine sarcoma, and MCF-7 breast cancer cells (IC50=3 nM for all).2 (–)-Cryptopleurine inhibits hypoxia-induced gene expression in a hypoxia response element (HRE) reporter assay (IC50=8.7 nM).3 (–)-Cryptopleurine (500 μg/mL) prevents lesion formation in tobacco (N. tabacum) plants infected with tobacco mosaic virus (TMV). It also inhibits protein synthesis by yeast and mammalian ribosomes.
Cat. No.: HY-N1261
CAS No.: 905929-95-5
Category:
Alkaloids Labiatae Derris robusta Pyridine Alkaloids Plants Disease Research Fields Cancer
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Cat. No.: HY-126598
CAS No.: 55945-75-0
Target:
Cat. No.: HY-N10206
CAS No.: 1319729-88-8
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Cancer
Target:
Cat. No.: HY-N8036
CAS No.: 1007860-05-0
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Cat. No.: HY-N18083
CAS No.: 123914-43-2
Target:
Cat. No.: HY-124130
CAS No.: 2170836-81-2
MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein .
Cat. No.: HY-N18294
CAS No.: 137196-25-9
Target:
Cat. No.: HY-165375
CAS No.: 34257-95-9
Plenolin is an anticancer agent. Plenolin exhibits inhibitory activity against human epidermoid carcinoma cells. Plenolin shows in vivo antitumor activity against ascites carcinosarcoma and lymphocytic leukemia in rodent models. Plenolin can be used for research related to ascites tumors and leukemia .
Cat. No.: HY-N18150
CAS No.: 244179-69-9
Category:
Target:
Cat. No.: HY-N17957
CAS No.: 2253112-90-0
Category:
Target:
Cat. No.: HY-141425
CAS No.: 79560-74-0
Target:
Research Areas:
NSC73306, a thiosemicarbazone, is a cell penetrant, cytotoxic agent that exhibits greater toxicity against cells expressing functional P-gp (P-glycoprotein) than against other cells .
Cat. No.: HY-N19312
CAS No.: 28164-57-0
Category:
Quinones Ebenaceae Phenols Polyphenols Benzene Quinones Plants
Cat. No.: HY-P991922
Research Areas:
Cat. No.: HY-N20721
CAS No.: 21416-14-8
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
