2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. Fc Receptor (FcR) Complement System Radionuclide-Drug Conjugates (RDCs)
  4. AKIR001

AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6. AKIR001 carries LALA-silencing mutations in its FcγR-binding domain to reduce FcγR and C1q interactions, minimizing tissue interactions and limiting CDC and ADCC risks. [177Lu] radiolabeled AKIR001, namely [177Lu]Lu-AKIR001, has anticancer activity against epidermoid carcinoma.

For research use only. We do not sell to patients.

AKIR001

AKIR001 Chemical Structure

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AKIR001 Related Antibodies

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Description

AKIR001 is a high-affinity human IgG1 antibody targeting CD44v6. AKIR001 carries LALA-silencing mutations in its FcγR-binding domain to reduce FcγR and C1q interactions, minimizing tissue interactions and limiting CDC and ADCC risks. [177Lu] radiolabeled AKIR001, namely [177Lu]Lu-AKIR001, has anticancer activity against epidermoid carcinoma[1].

Species Reactivity

Human
IC50 & Target

CD44
In Vitro

AKIR001 lacks CDC and ADCC activity in BxPC-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AKIR001 Related Antibodies
In Vivo

[177Lu]Lu-AKIR001 (5-15 MBq) exhibits dose-dependent efficacy in female BALB/c nu/nu mice with A431 cell xenograft (with complete response rates of 75-80%)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

960  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AKIR001 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AKIR001AKIR 001AKIR-001Fc Receptor (FcR)Complement SystemRadionuclide-Drug Conjugates (RDCs)Fc ReceptorMCF-7 cellsFcγRCD44v6C1qCD44v6-expressing xenograft modelsCDCBALB/c nu/nu miceADCCBxPC-3 cellscd44v6-positive solid cancersInhibitorinhibitorinhibit

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