(R,R)-Polysphorin
(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells.
For research use only. We do not sell to patients.
- CAS No.: 137196-25-9
- Formula: C23H30O7
- Molecular Weight:418.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All Parasite Isoforms
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Biological Activity
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Plasmodium falciparum sporozoites |
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Cell Line
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Type | Value | Description | References |
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| A549 | IC50 |
10 μM
Compound: 11
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Cytotoxicity against human A549 cells by sulforhodamine B assay
Cytotoxicity against human A549 cells by sulforhodamine B assay
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[PMID: 21936523] |
(R,R)-Polysphorin (Compound 1) (42 h for anti-plasmodium assay; 72 h for cytotoxicity assay) potently inhibits the growth of chloroquine-sensitive (D6) and chloroquine-resistant (W2) Plasmodium falciparum clones, with IC50 values of 404 ng/mL and 368 ng/mL, respectively[1].
(R,R)-Polysphorin has an ED50 of 2 μg/mL against human oral epidermoid carcinoma cell line KB, with selectivity indices of 5 and 6 for D6 and W2 clones, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Plasmodium falciparum D6 clone, Plasmodium falciparum W2 clone, human oral epidermoid cancer KB cells
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Concentration:Calibrated to determine IC50/ED50 values
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Incubation Time:42 h (antimalarial assay); 72 h (cytotoxicity assay)
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Result:Inhibited growth of P.falciparum.
falciparum D6 clone with an IC50 of 404 ± 65 ng/mL, inhibited growth of P.falciparum.
falciparum W2 clone with an IC50 of 368 ± 50 ng/mL, induced 50% cytotoxicity in KB cells at an ED50 of 2 μg/mL, and resulted in a selectivity index of 5 for D6 clone and 6 for W2 clone.
Chemical Information
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CAS No. 137196-25-9
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Molecular Weight 418.48
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Formula C23H30O7
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SMILES
O[C@H](C1=CC(OC)=C(C(OC)=C1)OC)[C@@H](C)OC2=C(C=C(C=C2OC)/C=C/C)OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)