137196-25-9
137196-25-9
Chemical Structure
(R,R)-Polysphorin
- CAS No.: 137196-25-9
- Formula:C23H30O7
- Molecular Weight:418.48
InChIKey: FLBWVIKFCMUTDS-UGZSOSCUSA-N
SMILES: O[C@H](C1=CC(OC)=C(C(OC)=C1)OC)[C@@H](C)OC2=C(C=C(C=C2OC)/C=C/C)OC
Biological Activity: (R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells[1].
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(R,R)-Polysphorin | (R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells. | |||||||||||||||||||||
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