2. Apoptosis Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Apoptosis Glutathione S-transferase Topoisomerase
  4. Diospyrin

Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma.

For research use only. We do not sell to patients.

Diospyrin

Diospyrin Chemical Structure

CAS No. : 28164-57-0

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Diospyrin Related Antibodies

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Topoisomerase Topo I Topo II DNA gyrase

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Description

Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma[1].

IC50 & Target

Topoisomerase I

 

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
0.8 μM
Compound: 1
Cytotoxicity against human A375 cells
Cytotoxicity against human A375 cells
[PMID: 20615584]
In Vitro

Diospyrin exhibits low cytotoxicity towards HL-60 and K-562 cells, with IC50 values greater than 100 μM[1].
Diospyrin is selectively cytotoxic towards A375, Hep2, and EAC cancer cells (IC50 values 0.8 μM, 3.6 μM, and 0.8 μM respectively) and far less toxic to nonmalignant PBMC (IC50 78.3 μM)[1].
Diospyrin inhibits multiple human recombinant GSTs with IC50 values between 0.3 and 0.6 μM, suggesting potential utility as a chemomodulator for GST-mediated drug resistance[1].
Diospyrin (160 μg/mL) completely inhibits EBV expression in Raji cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diospyrin Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: (I) HL-60 and K-562 cells
(II) A375, Hep2, and EAC cancer cells
Concentration: IC50 Test
Incubation Time: /
Result: Inhibited A375, Hep2, and EAC cancer cells with IC50 values of 0.8 μM, 3.6 μM, and 0.8 μM respectively, with low cytotoxicity towards HL-60 and K-562 cells, IC50s >100 μM.
In Vivo

Diospyrin exerts anticancer activity in Swiss strain A mice bearing Ehrlich ascites carcinoma by restoring hematological and serum parameters to near-normal levels, and prolongs the survival time of the mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

374.34

Formula

C22H14O6
CAS No.
SMILES

O=C1C=CC(C2=C(C(C3=CC(C4=C(C=C(C)C=C4C3=O)O)=O)=C(C)C=C12)O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Diospyrin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diospyrin28164-57-0ApoptosisGlutathione S-transferaseTopoisomeraseGlutathione transferasesGSTsmalignant skin melanomaDiospyros plantsehrlich ascites carcinomachronic myelogenic leukemiacervical epithelial carcinomabreast adenocarcinomaglutathione S-transferaseacute myeloblastic leukemiatopoisomerase Ipro-apoptotic activityInhibitorinhibitorinhibit

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