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Cat. No.: HY-N19312

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Diospyrin

Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma.

For research use only. We do not sell to patients.

CAS No.: 28164-57-0
Formula: C₂₂H₁₄O₆
Molecular Weight:374.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Diospyrin Chemical Structure

CAS No.: 28164-57-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

Topoisomerase I

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	0.8 μM Compound: 1	Cytotoxicity against human A375 cells Cytotoxicity against human A375 cells	[PMID: 20615584]

In Vitro

Diospyrin exhibits low cytotoxicity towards HL-60 and K-562 cells, with IC₅₀ values greater than 100 μM^[1].
Diospyrin is selectively cytotoxic towards A375, Hep2, and EAC cancer cells (IC₅₀ values 0.8 μM, 3.6 μM, and 0.8 μM respectively) and far less toxic to nonmalignant PBMC (IC₅₀ 78.3 μM)^[1].
Diospyrin inhibits multiple human recombinant GSTs with IC₅₀ values between 0.3 and 0.6 μM, suggesting potential utility as a chemomodulator for GST-mediated drug resistance^[1].
Diospyrin (160 μg/mL) completely inhibits EBV expression in Raji cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

(I) HL-60 and K-562 cells
(II) A375, Hep2, and EAC cancer cells
Concentration:

IC₅₀ Test
Incubation Time:

/
Result:

Inhibited A375, Hep2, and EAC cancer cells with IC₅₀ values of 0.8 μM, 3.6 μM, and 0.8 μM respectively, with low cytotoxicity towards HL-60 and K-562 cells, IC₅₀s >100 μM.

In Vivo

Diospyrin exerts anticancer activity in Swiss strain A mice bearing Ehrlich ascites carcinoma by restoring hematological and serum parameters to near-normal levels, and prolongs the survival time of the mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 28164-57-0
Molecular Weight 374.34
Formula C₂₂H₁₄O₆
SMILES

O=C1C=CC(C2=C(C(C3=CC(C4=C(C=C(C)C=C4C3=O)O)=O)=C(C)C=C12)O)=O
Structure Classification
- Quinones
- Benzene Quinones
- Phenols
- Polyphenols
Initial Source
- Plants
- Ebenaceae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sagar S, et al. Anti-cancer activities of diospyrin, its derivatives and analogues. Eur J Med Chem. 2010;45(9):3519-3530. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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