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Cat. No.: HY-112334

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EGFR-IN-198

EGFR-IN-198 is a selective EGFR inhibitor with subnanomolar irreversible inhibitory activity against EGFR. EGFR-IN-198 covalently binds to the kinase domain of EGFR and inhibits its autophosphorylation.

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CAS No.: 733009-42-2
Formule: C₁₆H₁₀Cl₃FN₄O
Masse moléculaire:399.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-198 Chemical Structure

CAS No.: 733009-42-2

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One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform EGFR :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.07 nM Compound: 4a	Inhibition of EGF Receptor autophosphorylation in A431 cell lysate Inhibition of EGF Receptor autophosphorylation in A431 cell lysate	[PMID: 16078851]
A-431	IC₅₀	25 nM Compound: 4a	Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM	[PMID: 16078851]

In Vitro

EGFR-IN-198 (compound 4a) potently inhibits EGFR autophosphorylation in A431 cell lysates with an IC₅₀ of 0.07 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 733009-42-2
Masse moléculaire 399.63
Formule C₁₆H₁₀Cl₃FN₄O
SMILES

O=C(NC=1C=CC2=NC=NC(NC=3C=C(Cl)C(Cl)=CC3F)=C2C1)CCl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mishani E, et al. High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J Med Chem. 2005;48(16):5337-5348. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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EGFR-IN-198

Voir tous les produits spécifiques à Isoform EGFR