EGFR-IN-198
Based on 1 Customer Validation
EGFR-IN-198 is a selective EGFR inhibitor with subnanomolar irreversible inhibitory activity against EGFR. EGFR-IN-198 covalently binds to the kinase domain of EGFR and inhibits its autophosphorylation.
For research use only. We do not sell to patients.
- CAS No.: 733009-42-2
- Formula: C16H10Cl3FN4O
- Molecular Weight:399.63
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
All EGFR Isoforms
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
0.07 nM
Compound: 4a
|
Inhibition of EGF Receptor autophosphorylation in A431 cell lysate
Inhibition of EGF Receptor autophosphorylation in A431 cell lysate
|
[PMID: 16078851] |
| A-431 | IC50 |
25 nM
Compound: 4a
|
Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM
Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM
|
[PMID: 16078851] |
In Vitro
Chemical Information
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CAS No. 733009-42-2
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Appearance Solid
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Molecular Weight 399.63
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Formula C16H10Cl3FN4O
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Color Yellow to brown
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SMILES
O=C(NC=1C=CC2=NC=NC(NC=3C=C(Cl)C(Cl)=CC3F)=C2C1)CCl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)