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Cat. No.: HY-112334

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EGFR-IN-198

EGFR-IN-198 is a selective EGFR inhibitor with subnanomolar irreversible inhibitory activity against EGFR. EGFR-IN-198 covalently binds to the kinase domain of EGFR and inhibits its autophosphorylation.

For research use only. We do not sell to patients.

CAS No.: 733009-42-2
Formula: C₁₆H₁₀Cl₃FN₄O
Molecular Weight:399.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

EGFR-IN-198 Chemical Structure

CAS No.: 733009-42-2

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Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A-431	IC₅₀	0.07 nM Compound: 4a	Inhibition of EGF Receptor autophosphorylation in A431 cell lysate Inhibition of EGF Receptor autophosphorylation in A431 cell lysate	[PMID: 16078851]
A-431	IC₅₀	25 nM Compound: 4a	Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM Inhibition of EGF Receptor autophosphorylation in A431 cell lysate; Range = 25-50 nM	[PMID: 16078851]

In Vitro

EGFR-IN-198 (compound 4a) potently inhibits EGFR autophosphorylation in A431 cell lysates with an IC₅₀ of 0.07 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 733009-42-2
Molecular Weight 399.63
Formula C₁₆H₁₀Cl₃FN₄O
SMILES

O=C(NC=1C=CC2=NC=NC(NC=3C=C(Cl)C(Cl)=CC3F)=C2C1)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mishani E, et al. High-affinity epidermal growth factor receptor (EGFR) irreversible inhibitors with diminished chemical reactivities as positron emission tomography (PET)-imaging agent candidates of EGFR overexpressing tumors. J Med Chem. 2005;48(16):5337-5348. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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EGFR-IN-198

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

EGFR-IN-198 Related Classifications

HY-112334 Related Classifications