2. Apoptosis
  3. Survivin
  4. MX106

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein.

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MX106

MX106 Chemical Structure

CAS No. : 2170836-81-2

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MX106 Related Antibodies

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Description

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
1 μM
Compound: MX-106
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
MDA-MB-435 IC50
2.1 μM
Compound: MX-106
Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
MDA-MB-435 IC50
3.5 μM
Compound: MX-106
Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
MDA-MB-453 IC50
1.6 μM
Compound: MX-106
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
RPMI-7951 IC50
1.1 μM
Compound: MX-106
Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
SK-BR-3 IC50
2.3 μM
Compound: MX-106
Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
[PMID: 34371464]
In Vitro

MX106 (0.03 nM-1 μM; 72 h) inhibits proliferation of human melanoma, epidermoid carcinoma, and colon cancer cells, with greater potency against P-glycoprotein-overexpressing multidrug-resistant cell lines, and exhibits an IC50 as low as 0.03 μM against SW620/Ad300 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MX106 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: A375, WM164, M14, M14/MDR1, KB-3-1, KB-C2, SW620, SW620/Ad300
Concentration: 0.03 nM-1 μM; 0.9 μM (A375); 1.1 μM (WM164); 0.8 μM (M14); 1.8 μM (M14/MDR1); 1.25 μM (KB-3-1); 0.33 μM (KB-C2); 0.15 μM (SW620); 0.03 μM (SW620/Ad300)
Incubation Time: 72 h
Result: Inhibited proliferation of A375 cells with an IC50 of 0.9 ± 0.1 μM.
Inhibited proliferation of WM164 cells with an IC50 of 1.1 ± 0.2 μM.
Inhibited proliferation of M14 cells with an IC50 of 0.8 ± 0.2 μM.
Inhibited proliferation of M14/MDR1 cells with an IC50 of 1.8 ± 0.4 μM, showing 2.3-fold resistance compared to parental M14 cells.
Inhibited proliferation of KB-3-1 cells with an IC50 of 1.25 ± 0.10 μM.
Inhibited proliferation of KB-C2 cells with an IC50 of 0.33 ± 0.12 μM, showing 3.8-fold greater potency compared to parental KB-3-1 cells.
Inhibited proliferation of SW620 cells with an IC50 of 0.15 ± 0.01 μM.
Inhibited proliferation of SW620/Ad300 cells with an IC50 of 0.03 ± 0.01 μM, showing 5-fold greater potency compared to parental SW620 cells.
Molecular Weight

390.53

Formula

C25H30N2O2
CAS No.
SMILES

OC1=C2N=CC=CC2=C(C=C1CN3CCCC3)COCC4=CC=C(C=C4)C(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MX106 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MX1062170836-81-2MX 106MX-106Survivinepidermoid carcinoma cellsmultidrug-resistant cell linessurvivinP-glycoproteinSW620/Ad300 cellshuman melanoma cellscolon cancer cellsInhibitorinhibitorinhibit

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HY-124130
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