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Cat. No.: HY-124130

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MX106

MX106 is a survivin inhibitor and an analog of UC-112 (HY-12842). MX106 inhibits the expression of survivin both in vitro and in vivo. MX106 suppresses the proliferation of human melanoma cells, epidermoid carcinoma cells and colon cancer cells, and also exerts inhibitory effects on multidrug-resistant cell lines overexpressing P-glycoprotein.

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CAS No.: 2170836-81-2
Formule: C₂₅H₃₀N₂O₂
Masse moléculaire:390.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

MX106 Chemical Structure

CAS No.: 2170836-81-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	1 μM Compound: MX-106	Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-435	IC₅₀	2.1 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-435/LCC6MDR cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-435	IC₅₀	3.5 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-435 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
MDA-MB-453	IC₅₀	1.6 μM Compound: MX-106	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
RPMI-7951	IC₅₀	1.1 μM Compound: MX-106	Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human RPMI-7951 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]
SK-BR-3	IC₅₀	2.3 μM Compound: MX-106	Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay Antiproliferative activity against human SK-BR-3 cells assessed as inhibition of cell growth incubated for 72 hrs by MTS assay	[PMID: 34371464]

In Vitro

MX106 (0.03 nM-1 μM; 72 h) inhibits proliferation of human melanoma, epidermoid carcinoma, and colon cancer cells, with greater potency against P-glycoprotein-overexpressing multidrug-resistant cell lines, and exhibits an IC₅₀ as low as 0.03 μM against SW620/Ad300 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

A375, WM164, M14, M14/MDR1, KB-3-1, KB-C2, SW620, SW620/Ad300
Concentration:

0.03 nM-1 μM; 0.9 μM (A375); 1.1 μM (WM164); 0.8 μM (M14); 1.8 μM (M14/MDR1); 1.25 μM (KB-3-1); 0.33 μM (KB-C2); 0.15 μM (SW620); 0.03 μM (SW620/Ad300)
Incubation Time:

72 h
Result:

Inhibited proliferation of A375 cells with an IC₅₀ of 0.9 ± 0.1 μM.
Inhibited proliferation of WM164 cells with an IC₅₀ of 1.1 ± 0.2 μM.
Inhibited proliferation of M14 cells with an IC₅₀ of 0.8 ± 0.2 μM.
Inhibited proliferation of M14/MDR1 cells with an IC₅₀ of 1.8 ± 0.4 μM, showing 2.3-fold resistance compared to parental M14 cells.
Inhibited proliferation of KB-3-1 cells with an IC₅₀ of 1.25 ± 0.10 μM.
Inhibited proliferation of KB-C2 cells with an IC₅₀ of 0.33 ± 0.12 μM, showing 3.8-fold greater potency compared to parental KB-3-1 cells.
Inhibited proliferation of SW620 cells with an IC₅₀ of 0.15 ± 0.01 μM.
Inhibited proliferation of SW620/Ad300 cells with an IC₅₀ of 0.03 ± 0.01 μM, showing 5-fold greater potency compared to parental SW620 cells.

Related Protocols :

Chemical Information

CAS No. 2170836-81-2
Masse moléculaire 390.53
Formule C₂₅H₃₀N₂O₂
SMILES

OC1=C2N=CC=CC2=C(C=C1CN3CCCC3)COCC4=CC=C(C=C4)C(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Wang Q, et al. Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors. Eur J Med Chem. 2018;149:211-224. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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