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Results for "

non-steroidal anti-inflammatory drugs (NSAIDs)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (13) Autophagy (3) Bacterial (2) Biochemical Assay Reagents (7) Caspase (3) COX (53) Cytochrome P450 (1) Drug Derivative (3) Drug Isomer (1) Drug Metabolite (6) Environmental Pollutants (1) Fungal (1) Interleukin Related (1) Isotope-Labeled Compounds (12) Leukotriene Receptor (1) Lipoxygenase (1) Microtubule/Tubulin (4) NO Synthase (1) NOD-like Receptor (NLR) (3) PGE synthase (6) PPAR (1) Prostaglandin Receptor (4) Reference Standards (16) TNF Receptor (2) β-glucuronidase (1)
By Research Areas:	Cancer (23) Endocrinology (2) Infection (2) Inflammation/Immunology (72) Metabolic Disease (2) Neurological Disease (3)

By Targets:

Apoptosis (13)

Autophagy (3)

Bacterial (2)

Biochemical Assay Reagents (7)

Caspase (3)

COX (53)

Cytochrome P450 (1)

Drug Derivative (3)

Drug Isomer (1)

Drug Metabolite (6)

Environmental Pollutants (1)

Fungal (1)

Interleukin Related (1)

Isotope-Labeled Compounds (12)

Leukotriene Receptor (1)

Lipoxygenase (1)

Microtubule/Tubulin (4)

NO Synthase (1)

NOD-like Receptor (NLR) (3)

PGE synthase (6)

PPAR (1)

Prostaglandin Receptor (4)

Reference Standards (16)

TNF Receptor (2)

β-glucuronidase (1)

By Research Areas:

Cancer (23)

Endocrinology (2)

Infection (2)

Inflammation/Immunology (72)

Metabolic Disease (2)

Neurological Disease (3)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14398

Celecoxib 60+ Cited Publications SC 58635	COX	Infection Neurological Disease Inflammation/Immunology Cancer
Celecoxib,a selective and BBB-permeable non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-16569

Colchicine 60+ Cited Publications	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)	Cancer
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-B0580

Ketorolac 3 Publications Verification RS37619	COX Apoptosis	Inflammation/Immunology Cancer
Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor	Inflammation/Immunology Cancer
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

HY-B1138

Fenbufen 1 Publications Verification CL-82204	COX Caspase	Infection Neurological Disease Inflammation/Immunology Cancer
Fenbufen (CL-82204) is an orally active **non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀**s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-B1799

Tolmetin 1 Publications Verification	COX	Inflammation/Immunology Cancer
Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) .

HY-135731

4-Methylamino antipyrine	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-106628

Sudoxicam 2 Publications Verification	COX	Inflammation/Immunology
Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity .

HY-B0619

Zaltoprofen 2 Publications Verification CN100	COX	Inflammation/Immunology
Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC₅₀s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain .

HY-118189

Misoprostol acid 1 Publications Verification	Prostaglandin Receptor	Inflammation/Immunology
Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers . Misoprostol is an oral agent used to induce labor .

HY-B0270

Suprofen 1 Publications Verification TN-762	PGE synthase	Inflammation/Immunology
Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

HY-120824

Mofezolac 2 Publications Verification	COX	Inflammation/Immunology
Mofezolac, a non-steroidal anti-inflammatory drug (NSAID), is a selective, reversible and orally active COX-1 inhibitor with an IC₅₀ of 1.44 nM. Mofezolac shows weak inhibitory activity on COX-2 (IC₅₀ of 447 nM). Mofezolac can relieve pain and has anti-inflammatory activities .

HY-N7133

Diphenylamine hydrochloride N-Phenylaniline hydrochloride	Fungal Bacterial	Metabolic Disease
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .

HY-15028

Otenaproxesul ATB-346	COX Apoptosis	Inflammation/Immunology
Otenaproxesul (ATB-346), an orally active non-steroidal anti-inflammatory drug (NSAID), inhibits cyclooxygenase-1 and 2 (COX-1 and 2). Otenaproxesul possesses antiinflammatory and antinociceptive activities .

HY-126393

Carboxymethyl-β-cyclodextrin	Biochemical Assay Reagents	Others
Carboxymethyl-β-cyclodextrin is a cationic cyclodextrin used as a carrier for drugs. It has been shown to bind nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity and selectivity.

HY-B1054

Famprofazone	COX	Inflammation/Immunology
Famprofazone is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the pyrazolone series, and it has analgesic, anti-inflammatory, and antipyretic effects.

HY-14398S

Celecoxib-d7 SC 58635-d₇	COX	Inflammation/Immunology Cancer
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-14398R

Celecoxib (Standard) SC 58635 (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Celecoxib (Standard) is the analytical standard of Celecoxib. This product is intended for research and analytical applications. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-119447

Mavacoxib	COX	Inflammation/Immunology
Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-B1489

Tolmetin sodium dihydrate 1 Publications Verification	COX	Inflammation/Immunology Cancer
Tolmetin sodium dihydrate is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium dihydrate is a non-steroidal anti-inflammatory drug (NSAID) .

HY-109547

Diclofenac epolamine Diclofenac hydroxyethylpyrrolidine	COX	Inflammation/Immunology Cancer
Flector Patch (Diclofenac epolamine) is a non-steroidal anti-inflammatory drug (NSAID) . Flector Patch is used for relieving arthritis Pain, acute Pain, osteoarthritis, and actinic Keratosis. Flector Patch has good skin absorption characteristics without local adverse reactions and allergies .

HY-A0273

Propyphenazone 4-Isopropylantipyrine; Isopropylphenazone	COX	Inflammation/Immunology
Propyphenazone (4-Isopropylantipyrine) is an orally active nonacidic pyrazole nonsteroidal anti-inflammatory drug (NSAID). Propyphenazone is a weak nonselective COX inhibitor. Propyphenazone has the effect of reducing pain and antipyretic activity with minimal anti-inflammatory activity .

HY-16569R

Colchicine (Standard)	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-16569B

Colchicine,suitable for plant cell culture	Biochemical Assay Reagents Microtubule/Tubulin	Inflammation/Immunology Cancer
Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .

HY-17484

Ampiroxicam 2 Publications Verification CP 65703	Drug Derivative	Inflammation/Immunology
Ampiroxicam is an orally active prodrug of non-steroidal anti-inflammatory drug (NSAID). Ampiroxicam inhibits paw swelling in adjuvant-induced arthritis and acute inflammation models, and suppresses phenylbenzoquinone-induced stretching responses in mice. Ampiroxicam is rapidly and completely converted to Piroxicam (HY-B0253) via non-specific esterases and first-pass metabolism. Ampiroxicam induces contact hypersensitivity and photosensitivity reactions through photoproducts generated by UVA. Ampiroxicam can be used in research related to photosensitivity, adjuvant-induced arthritis, rheumatism, osteoarthritis and other inflammatory diseases .

HY-15029S

(±)-Naproxen-d3 (Rac)-Naproxen-d₃	COX Isotope-Labeled Compounds	Inflammation/Immunology
(±)-Naproxen-d₃ is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID) .

HY-W663740

1-Methyl-4-nitrosopiperazine MNP; MeNP; N-Methyl-N'-nitrosopiperazine	Biochemical Assay Reagents	Others
1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-14398S1

Celecoxib-d3 SC 58635-d₃	COX	Inflammation/Immunology Cancer
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-W322573

(R)-Ketoprofen	COX	Inflammation/Immunology
(R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties. (R)-Ketoprofen does not significantly amplify the increase of inflammatory cytokines (such as tumor necrosis factor (TNF) and interleukin-1 (IL-1)) induced by LPS, but it can inhibit the anti-inflammatory activity of (S)-Ketoprofen .

HY-W121901

Naproxen glucuronide (S)-Naproxen-β-D-glucuronide	COX	Inflammation/Immunology
Naproxen glucuronide ((S)-Naproxen-β-D-glucuronide) is a non-selective COX inhibitor. Naproxen glucuronide, a metabolite of naproxen, is a nonsteroidal anti-inflammatory drug (NSAID) of the propionic acid class (the same as ibuprofen) that relieves pain, fever, swelling, and stiffness .

HY-B0580R

Ketorolac (Standard) RS37619 (Standard)	Reference Standards COX Apoptosis	Inflammation/Immunology Cancer
Ketorolac (Standard) is the analytical standard of Ketorolac. This product is intended for research and analytical applications. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .

HY-103385

NCX4040 NO-Aspirin	Apoptosis	Inflammation/Immunology Cancer
NCX4040 (NO-Aspirin), a non-steroidal anti-inflammatory drug (NSAID), is a nitric oxide (NO) releasing form of Aspirin. NCX4040 induces apoptosis in PC3 metastatic prostate cancer cells. NCX4040 has anti-inflammatory and anti-cancer effects .

HY-135731A

4-Methylamino antipyrine hydrochloride	COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-131495

(S)-6-O-Desmethylnaproxen (S)-6-Desmethyl Naproxen	COX	Inflammation/Immunology
(S)-6-O-Desmethylnaproxen ((S)-6-Desmethyl Naproxen) is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen). (S)-6-O-Desmethylnaproxen is formed from (S)-naproxen by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.

HY-W160127

N-Hydroxymethyl succinimide N-Methylolsuccinimide	Biochemical Assay Reagents	Others
N-Hydroxymethyl succinimide (N-Methylolsuccinimide) is a promoiety used as a prodrug carrier for non-steroidal anti-inflammatory drugs (NSAIDs). N-Hydroxymethyl succinimide enhances the lipophilicity of NSAIDs and reducing the gastrointestinal toxicity of NSAIDs. N-Hydroxymethyl succinimide is promising for research of anti-inflammatory drug delivery system .

HY-106907

Furprofen 1 Publications Verification	PGE synthase	Inflammation/Immunology Endocrinology
Furprofen is an non-steroidal anti-inflammatory drug (NSAID) with analgesic properties . Furprofen acts via the inhibition of prostaglandin (PGE) synthesis. Furprofen can be treated orally for the relief of pain .

HY-14398G

Celecoxib SC 58635	COX	Inflammation/Immunology
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-119447S

Mavacoxib-d4	Isotope-Labeled Compounds COX	Inflammation/Immunology
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride	Isotope-Labeled Compounds COX Drug Metabolite	Inflammation/Immunology
4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-105641

Morazone	Drug Derivative	Inflammation/Immunology
Morazone is a non-steroidal anti-inflammatory drug (NSAID) .

HY-17481

Bumadizone	COX	Inflammation/Immunology
Bumadizone is a non-steroidal anti-inflammatory drug (NSAID) and can relieve pain .

HY-137157

Suprofen L-lysine TN-762 L-lysine	PGE synthase	Inflammation/Immunology
Suprofen L-lysine (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

HY-105939

Isofezolac	PGE synthase	Inflammation/Immunology
Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin-synthetase. Isofezolac anti-inflammatory, and antipyretic properties .

HY-137160

(±)-Ketoprofen glucuronide	COX	Inflammation/Immunology
(±)-Ketoprofen glucuronide is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Ketoprofen (HY-B0227) .

HY-124351

5'-Hydroxy meloxicam	COX	Inflammation/Immunology
5'-Hydroxy meloxicam is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Meloxicam (HY-B0261) .

HY-144773A

Loxoprofenol-SRS tromethamine HR1405–01	COX	Inflammation/Immunology
Loxoprofenol-SRS tromethamine (HR1405-01), an active metabolite of Loxoprofen, is a Safe intravenous non-steroidal anti-inflammatory drug (NSAID) with superior anti-inflammatory and analgesic activities .

HY-B0270R

Suprofen (Standard) TN-762 (Standard)	Reference Standards PGE synthase	Inflammation/Immunology
Suprofen (Standard) is the analytical standard of Suprofen. This product is intended for research and analytical applications. Suprofen (TN-762) is a non-steroidal anti-inflammatory drug (NSAID).

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	COX	Inflammation/Immunology
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-106093

Eltenac	COX	Inflammation/Immunology
Eltenac, a non-steroidal anti-inflammatory drug (NSAID), is a COX inhibitor. Eltenac shows IC50 of 0.03 μM for both COX-1 and COX-2 in isolated human whole blood .

HY-106628R

Sudoxicam (Standard)	Reference Standards COX	Inflammation/Immunology
Sudoxicam (Standard) is the analytical standard of Sudoxicam. This product is intended for research and analytical applications. Sudoxicam is a reversible and orally active COX antagonist and a non-steroidal anti-inflammatory drug (NSAID) from the enol-carboxamide class. Sudoxicam has potent anti-inflammatory, anti-edema and antipyretic activity .

Cat. No.	Product Name

HY-L130

Non-steroidal Anti-Inflammatory Compound Library

629 compounds

Non-steroidal anti-inflammatory drugs (NSAIDs) are members of a therapeutic drug class with potent anti-inflammatory, analgesic and antipyretic activity, and are among the most widely used drugs worldwide. The most prominent NSAIDs are aspirin, ibuprofen, and naproxen.

The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX), based on which NSAIDs can be classified into two types: non-selective and COX-2 selective. Most NSAIDs are non-selective and inhibit both COX-1 and COX-2 activity.

MCE offers a unique collection of 629 non-steroidal compounds with identified anti-inflammatory activity. MCE non-steroidal anti-inflammatory library is a useful tool for the study of anti-inflammatory drugs and pharmacology.

Cat. No.	Product Name	Type

HY-14398G

Celecoxib SC 58635	Fluorescent Dyes
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Fluorescent Dyes
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Type

HY-126393

Carboxymethyl-β-cyclodextrin	Biochemical Assay Reagents
Carboxymethyl-β-cyclodextrin is a cationic cyclodextrin used as a carrier for drugs. It has been shown to bind nonsteroidal anti-inflammatory drugs (NSAIDs) with high affinity and selectivity.

HY-16569B

Colchicine,suitable for plant cell culture

Biochemical Assay Reagents

Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture .

HY-14398G

Celecoxib SC 58635	Biochemical Assay Reagents
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	Biochemical Assay Reagents
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16569

Colchicine 60+ Cited Publications	Structural Classification Natural Products other families Classification of Application Fields Plants Disease Research Fields Source Classification Cancer	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

HY-B0367

Lornoxicam Chlortenoxicam; Ro 13-9297	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis COX NO Synthase Interleukin Related Prostaglandin Receptor TNF Receptor
Lornoxicam (Chlortenoxicam) is an orally active oxycontin nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory, antipyretic and anticancer activities. Lornoxicam exhibits good inhibitory effects on both COX-1 and COX-2 (COX-1: IC₅₀=0.005 μM; COX-2:IC₅₀=0.008 μM) and inhibits the production of NO by iNOS (IC₅₀=65 μM) and the proinflammatory cytokine IL-6 (IC₅₀=54 μM). Lornoxicam also inhibits tumor cell proliferation and migration and induces tumor cell apoptosis. Lornoxicam can be used in the study of inflammatory pain, colorectal cancer and breast cancer .

HY-N7133

Diphenylamine hydrochloride N-Phenylaniline hydrochloride	Natural Products Classification of Application Fields Other Diseases Amberboa moschata (L.) DC. Umbelliferae Plants Disease Research Fields Source Classification	Fungal Bacterial
Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent .

HY-16569R

Colchicine (Standard)	Structural Classification Natural Products other families Plants Source Classification	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research .

Cat. No.	Product Name	Chemical Structure

HY-14398S

Celecoxib-d7
Celecoxib-d₇ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-15029S

(±)-Naproxen-d3
(±)-Naproxen-d₃ is the deuterium labeled (±)-Naproxen. (±)-Naproxen is a non-steroidal anti-inflammatory drug (NSAID) .

HY-14398S1

Celecoxib-d3
Celecoxib-d₃ is the deuterium labeled Celecoxib. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM .

HY-119447S

Mavacoxib-d4
Mavacoxib-d₄ is the deuterium labeled Mavacoxib. Mavacoxib is a selective, oral long-acting cyclooxygenase-2 (COX-2) inhibitor and a long-acting non-steroidal anti-inflammatory drug (NSAID). Mavacoxib is used to treat pain and inflammation associated with degenerative joint disease in dogs .

HY-135731AS

4-Methylamino antipyrine-d3 hydrochloride

4-Methylamino antipyrine-d₃ (hydrochloride) is deuterium labeled 4-Methylamino antipyrine (hydrochloride). 4-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-B1799S

Tolmetin-d3
Tolmetin-d₃ is the deuterium labeled Tolmetin. Tolmetin is an orally active and potent COX inhibitor with IC₅₀s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin is a non-steroidal anti-inflammatory drug (NSAID) .

HY-B0619S1

Zaltoprofen-13C,d3
Zaltoprofen- ¹³C,d₃ is the ¹³C- and deuterium labeled Zaltoprofen. Zaltoprofen (CN100), a non-steroidal anti-inflammatory drug (NSAID), is a preferential and orally active COX-2 inhibitor, with IC₅₀s of 1.3 and 0.34 μM for COX-1 and COX-2, respectively. Zaltoprofen exhibits powerful anti-inflammatory effects as well as an analgesic action on inflammatory pain .

HY-W700581

1-(Methyl-d3)-4-nitrosopiperazine
1-(Methyl-d₃)-4-nitrosopiperazine is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-118189S

Misoprostol acid-d5

Misoprostol acid-d₅ is deuterium labeled Misoprostol acid. Misoprostol acid is an active metabolite of Misoprostol. Misoprostol is a synthetic analogue of prostaglandin E1 (PGE1), extensively absorbed, and undergoes rapid de-esterification to Misoprostol acid in the gastrointestinal tract after oral administration. Misoprostol can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers . Misoprostol is an oral agent used to induce labor .

HY-B0580S2

Ketorolac-13C6

Ketorolac- ¹³C₆ (RS37619- ¹³C₆) is ¹³C labeled Ketorolac. Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC₅₀s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research .

HY-B1138S

Fenbufen-d9

Fenbufen-d₉ (CL-82204-d₉) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC₅₀s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor .

HY-W416548S

1-Methyl-4-nitro piperazine-d11
1-Methyl-4-nitro piperazine-d₁₁ is the deuterium labeled 1-Methyl-4-nitro piperazine. 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

HY-W701503

4-Methylamino antipyrine-d3-1

4-Methylamino antipyrine-d₃-1 is the deuterium labeled 4-Methylamino antipyrine-1. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever . 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties .

HY-W726845

1-Methyl-4-nitrosopiperazine-d11
1-Methyl-4-nitrosopiperazine-d₁₁ (MNP-d₁₁) is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics .

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14398GL

Celecoxib (GMP Like) SC 58635 (GMP Like)	COX	Inflammation/Immunology
Celecoxib (SC 58635) GMP Like is a GMP-class Celecoxib (HY-14398). Celecoxib, a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

HY-14398G

Celecoxib SC 58635	COX	Inflammation/Immunology
Celecoxib (GMP) is Celecoxib (HY-14398) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC₅₀ of 40 nM.

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non-steroidal anti-inflammatory drugs (NSAIDs)

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