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Results for "

peripheral vasodilator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenosine Receptor (1) Adrenergic Receptor (11) Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Autophagy (5) Bacterial (1) Calcium Channel (17) CGRP Receptor (4) Cholinesterase (ChE) (2) Dopamine Receptor (5) Drug Derivative (4) Endogenous Metabolite (12) Endothelin Receptor (1) Free Fatty Acid Receptor (2) iGluR (2) Influenza Virus (2) Isotope-Labeled Compounds (5) Monoamine Oxidase (2) PDGFR (5) Phosphodiesterase (PDE) (4) Potassium Channel (7) Prostaglandin Receptor (6) Reference Standards (16) Sodium Channel (6)
By Research Areas:	Cancer (5) Cardiovascular Disease (53) Endocrinology (8) Infection (3) Inflammation/Immunology (3) Metabolic Disease (5) Neurological Disease (16)

By Targets:

5-HT Receptor (1)

Adenosine Receptor (1)

Adrenergic Receptor (11)

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Autophagy (5)

Bacterial (1)

Calcium Channel (17)

CGRP Receptor (4)

Cholinesterase (ChE) (2)

Dopamine Receptor (5)

Drug Derivative (4)

Endogenous Metabolite (12)

Endothelin Receptor (1)

Free Fatty Acid Receptor (2)

iGluR (2)

Influenza Virus (2)

Isotope-Labeled Compounds (5)

Monoamine Oxidase (2)

PDGFR (5)

Phosphodiesterase (PDE) (4)

Potassium Channel (7)

Prostaglandin Receptor (6)

Reference Standards (16)

Sodium Channel (6)

By Research Areas:

Cancer (5)

Cardiovascular Disease (53)

Endocrinology (8)

Infection (3)

Inflammation/Immunology (3)

Metabolic Disease (5)

Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 87 Publications Verification Isoproterenol hydrochloride	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0112

Minoxidil 10+ Cited Publications U10858	Potassium Channel Endogenous Metabolite	Cardiovascular Disease Cancer
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-P1071

α-CGRP (human) 4 Publications Verification Calcitonin gene-related peptide	CGRP Receptor	Cardiovascular Disease
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects .

HY-B0131

Prostaglandin E1 20+ Cited Publications Alprostadil; PGE1	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-P0203

α-CGRP (mouse, rat) Maximum Cited Publications 8 Publications Verification CGRP (83-119), mouse, rat	CGRP Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .

HY-B0233

Isradipine PN 200-110	Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (PN 200-110) is an orally active and blood-brain barrier permeability L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-108353

Isoprenaline Maximum Cited Publications 87 Publications Verification	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0358

Flunarizine 5+ Cited Publications	Calcium Channel Sodium Channel Dopamine Receptor	Cardiovascular Disease Neurological Disease
Flunarizine is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine is a D₂ dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-B0358A

Flunarizine dihydrochloride 5+ Cited Publications	Calcium Channel Sodium Channel Dopamine Receptor	Cardiovascular Disease Neurological Disease
Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-101701

Hepronicate Megrin	Drug Derivative	Cardiovascular Disease
Hepronicate, a nicotinic acid derivative, is a peripheral vasodilator with blood lipid lowering action. Hepronicate works by improving peripheral circulatory disturbances .

HY-B1815

Xanthinol Nicotinate Xanthinol Niacinate	PDGFR	Cardiovascular Disease
Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-B1107

Naftidrofuryl oxalate Nafronyl oxalate salt	5-HT Receptor	Cardiovascular Disease
Naftidrofuryl oxalate (Nafronyl oxalate salt) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator, enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.

HY-12882

Ifenprodil 5+ Cited Publications NP-120; RC-61-91	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-P0203A

α-CGRP (mouse, rat) TFA Maximum Cited Publications 8 Publications Verification CGRP (83-119), mouse, rat TFA	CGRP Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .

HY-B1021

Vincamine 1 Publications Verification	Free Fatty Acid Receptor	Cardiovascular Disease Metabolic Disease
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator* and* exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-B1016

Trapidil AR-12008	PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor	Cardiovascular Disease Neurological Disease
Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A₂ synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury .

HY-P1071A

α-CGRP (human) TFA 4 Publications Verification Calcitonin gene-related peptide TFA	CGRP Receptor	Cardiovascular Disease
α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects .

HY-B0112R

Minoxidil (Standard) U10858 (Standard)	Reference Standards Potassium Channel Endogenous Metabolite	Cardiovascular Disease Cancer
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

HY-B1440

Ethaverine hydrochloride	Calcium Channel Monoamine Oxidase	Cardiovascular Disease
Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease .

HY-119440

Xanthinol	PDGFR	Cardiovascular Disease
Xanthinol is a vasodilator that can be used for the study of peripheral and cerebral vascular disorders .

HY-23196S

Minoxidil-d10	Potassium Channel	Neurological Disease
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

HY-B0484

Buflomedil hydrochloride	Adrenergic Receptor	Cardiovascular Disease
Buflomedil hydrochloride, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders .

HY-108353A

Isoprenaline hemisulfate Maximum Cited Publications 87 Publications Verification	Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-101610

OPC-28326	Adrenergic Receptor	Cardiovascular Disease Endocrinology
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with K_i of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively.

HY-B0358AR

Flunarizine dihydrochloride (Standard)	Reference Standards Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine (dihydrochloride) (Standard) is the analytical standard of Flunarizine (dihydrochloride). This product is intended for research and analytical applications. Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-Z8176

(Z)-Flunarizine	Sodium Channel	Neurological Disease
(Z)-Flunarizine is the (Z)-isomer of Flunarizine (HY-B0358). Flunarizine is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-B0468R

Isoprenaline hydrochloride (Standard) Isoproterenol hydrochloride (Standard)	Reference Standards Adrenergic Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B1815R

Xanthinol Nicotinate (Standard) Xanthinol Niacinate (Standard)	PDGFR Reference Standards	Cardiovascular Disease
Xanthinol Nicotinate (Standard) is the analytical standard of Xanthinol Nicotinate. This product is intended for research and analytical applications. Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-B0358AS

Flunarizine-d8 dihydrochloride	Sodium Channel Dopamine Receptor Calcium Channel Isotope-Labeled Compounds	Neurological Disease
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-106538

Cadralazine ISF 2469	Drug Derivative	Cardiovascular Disease
Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator .

HY-U00134

Benzcyclane Bencyclane; Benzcyclan	Calcium Channel	Cardiovascular Disease
Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Reference Standards Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology Cancer
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-B1016R

Trapidil (Standard) AR-12008 (Standard)	Reference Standards PDGFR Phosphodiesterase (PDE) Prostaglandin Receptor	Cardiovascular Disease Cancer
Trapidil (Standard) (AR-12008 (Standard)) is the analytical standard of Trapidil (HY-B1016R). This product is intended for research and analytical applications. Trapidil (AR-12008) is an orally active vasodilator and antiplatelet agent. Trapidil antagonizes platelet-derived growth factor (PDGF), inhibits phosphodiesterase, thromboxane A2 synthesis and pro-inflammatory cytokine production. Trapidil promotes prostacyclin biosynthesis, reduces lipid peroxidation, regulates nitric oxide metabolism, and inhibits cell proliferation and migration. Trapidil exerts tissue-protective effects, regulates bone turnover, and inhibits pyroptosis via the GPX3/Nrf2 pathway. Trapidil is applicable to research related to renal ischemia-reperfusion injury, chronic stable angina, restenosis, meningioma, diabetic cardiomyopathy and peripheral nerve crush injury.

HY-B1440R

Ethaverine hydrochloride (Standard)	Reference Standards Calcium Channel Monoamine Oxidase	Cardiovascular Disease
Ethaverine (hydrochloride) (Standard) is the analytical standard of Ethaverine (hydrochloride). This product is intended for research and analytical applications. Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease .

HY-B0233R

Isradipine (Standard) PN 200-110 (Standard)	Reference Standards Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine (Standard) is the analytical standard of Isradipine. This product is intended for research and analytical applications. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233S2

Isradipine-d7 PN 200-110-d₇	Calcium Channel Autophagy Isotope-Labeled Compounds	Cardiovascular Disease Neurological Disease
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0484A

Buflomedil	Adrenergic Receptor	Cardiovascular Disease
Buflomedil, a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil can be used for the study of peripheral circulatory disorders .

HY-B0358R

Flunarizine (Standard)	Reference Standards Calcium Channel Sodium Channel Dopamine Receptor	Neurological Disease
Flunarizine (Standard) is the analytical standard of Flunarizine. This product is intended for research and analytical applications. Flunarizine is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine is a D₂ dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-B0484R

Buflomedil hydrochloride (Standard)	Reference Standards Adrenergic Receptor	Cardiovascular Disease
Buflomedil hydrochloride (Standard) is the analytical standard of Buflomedil hydrochloride (HY-B0484). This product is intended for research and analytical applications. Buflomedil hydrochloride (Standard), a vasodilator agent, is an orally active α1A-adrenoceptor antagonist with K_is of 4.06 µM and 6.84 µM for α1A-AR and α1B-AR, respectively. Buflomedil hydrochloride can be used for the study of peripheral circulatory disorders .

HY-126036

CH-141	Endothelin Receptor	Cardiovascular Disease
CH-141 is a peripheral vasodilator, that can be used in hypertension research .

HY-101759

Isoxsuprine-monoester-1	Others	Cardiovascular Disease
Isoxsuprine-monoester-1, a monoester of isoxsuprine, is a long acting peripheral vasodilator.

HY-101128R

Bicyclomycin benzoate (Standard) FR2054 (Standard)	Reference Standards Bacterial Antibiotic	Infection
Ethaverine (hydrochloride) (Standard) is the analytical standard of Ethaverine (hydrochloride). This product is intended for research and analytical applications. Ethaverine hydrochloride, a derivative of papaverine, inhibits cardiac L-type calcium channel. Ethaverine hydrochloride is a peripheral vasodilator and antispasmodic agent. Ethaverine hydrochloride can be used for research of peripheral vascular disease .

HY-106045

Imazodan CI 914 free base	Phosphodiesterase (PDE)	Cardiovascular Disease
Imazodan is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan serves also as a peripheral vasodilator .

HY-B0233S1

Isradipine-d6 PN 200-110-d₆	Calcium Channel Autophagy	Neurological Disease
Isradipine-d₆ is the deuterium labeled Isradipine . Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-111018

FPL 62129	Calcium Channel	Cardiovascular Disease
FPL 62129 is an antagonist for calcium channel. FPL 62129 reduces blood pressure and total peripheral resistance, increases the cardiac contractility and cardiac output in anarsthetised beagle model. FPL 62129 also serves as a vasodilator and a direct decelerator .

HY-106045A

Imazodan hydrochloride CI 914	Phosphodiesterase (PDE)	Cardiovascular Disease
Imazodan hydrochloride is the hydrochloride form of Imazodan (HY-106045). Imazodan hydrochloride is a selective inhibitor for phosphodiesterase III (PDE III), which increases myocardial contractility by blocking the cAMP degradation, and improves the contractile function of heart. Imazodan hydrochloride serves also as a peripheral vasodilator .

HY-B0233S

Isradipine-d3	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease Neurological Disease
Isradipine-d₃ (PN 200-110-d₃) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-105651A

Butalamine hydrochloride	Cholinesterase (ChE)	Cardiovascular Disease
Butalamine (hydrochloride) is a peripheral vasodilator with local anesthetic effects. :Butalamine (hydrochloride) can produce in animals coronary vasodilation, local anaesthesia, analgesia and a papaverine like action in duodenal preparations. Butalamine (hydrochloride) causes a slowing in rate of spontaneous activity, a decrease in amplitude and a reduction in isolated human smooth muscle .

HY-B0131A

Alprostadil sodium	Prostaglandin Receptor	Cardiovascular Disease
Alprostadil sodium is a prostaglandin receptor ligand that exhibits Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in mice, respectively. It promotes vasodilation and inhibits platelet aggregation, making it a useful vasodilator for investigating peripheral vascular disease.

Cat. No.	Product Name	Target	Research Area

HY-P1071

α-CGRP (human) 4 Publications Verification Calcitonin gene-related peptide	CGRP Receptor	Cardiovascular Disease
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects .

HY-P0203

α-CGRP (mouse, rat) Maximum Cited Publications 8 Publications Verification CGRP (83-119), mouse, rat	CGRP Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .

HY-P0203A

α-CGRP (mouse, rat) TFA Maximum Cited Publications 8 Publications Verification CGRP (83-119), mouse, rat TFA	CGRP Receptor	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .

HY-P1071A

α-CGRP (human) TFA 4 Publications Verification Calcitonin gene-related peptide TFA	CGRP Receptor	Cardiovascular Disease
α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0468

Isoprenaline hydrochloride Maximum Cited Publications 87 Publications Verification Isoproterenol hydrochloride	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0112

Minoxidil 10+ Cited Publications U10858	Cardiovascular Disease Alkaloids Piperidine Alkaloids Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Potassium Channel Endogenous Metabolite
Minoxidil (U10858) is an ATP-sensitive potassium (K_ATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC₅₀ of 20 μM .

HY-B0131

Prostaglandin E1 20+ Cited Publications Alprostadil; PGE1	Cardiovascular Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-108353

Isoprenaline Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-B1021

Vincamine 1 Publications Verification	Apocynaceae Cardiovascular Disease Alkaloids Classification of Application Fields Plants Disease Research Fields Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Free Fatty Acid Receptor
Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator* and* exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-B0112R

Minoxidil (Standard) U10858 (Standard)	Structural Classification Alkaloids Piperidine Alkaloids Endogenous metabolite Source Classification	Reference Standards Potassium Channel Endogenous Metabolite
Minoxidil (Standard) is the analytical standard of Minoxidil. This product is intended for research and analytical applications. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM .

HY-108353A

Isoprenaline hemisulfate Maximum Cited Publications 87 Publications Verification	Cardiovascular Disease Alkaloids Classification of Application Fields Other Alkaloids Phenols Polyphenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Adrenergic Receptor Endogenous Metabolite
Isoprenaline hemisulfate is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0468R

Isoprenaline hydrochloride (Standard) Isoproterenol hydrochloride (Standard)	Structural Classification Alkaloids Other Alkaloids Phenols Polyphenols Endogenous metabolite Source Classification	Reference Standards Adrenergic Receptor Endogenous Metabolite
Isoprenaline (hydrochloride) (Standard) is the analytical standard of Isoprenaline (hydrochloride). This product is intended for research and analytical applications. Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-B0131R

Prostaglandin E1 (Standard) Alprostadil(Standard); PGE1 (Standard)	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Prostaglandin Receptor Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-W007888R

2-Hydroxy-4-methylbenzaldehyde (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Phenols Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Prostaglandin E1 (Standard) is the analytical standard of Prostaglandin E1. This product is intended for research and analytical applications. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

HY-B1021R

Vincamine (Standard)	Apocynaceae Alkaloids Structural Classification Plants Indole Alkaloids Catharanthus roseus (L.) G. Don Source Classification	Reference Standards Free Fatty Acid Receptor
Vincamine (Standard) is the analytical standard of Vincamine. This product is intended for research and analytical applications. Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator* and* exerts a selective vasoregulator action on the brain microcapilar circulation . Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research .

HY-N16779

Angustine	Structural Classification Alkaloids Nauclea officinalis (Pirre ex Pitard) Merr. Rubiaceae Plants Indole Alkaloids Source Classification	Others
Angustine is a monoterpene indole alkaloid vasodilator. Angustine exhibits potent vasodilatory activity on isolated rat aorta at a concentration of 10 μM (vasodilation rate exceeding 90%). Angustine can be used in the study of diseases such as hypertension, cerebral vasospasm, and peripheral circulatory disorders. Angustine can be naturally extracted from the bark of Nauclea officinalis and is also present in plants of the genera Mitragyna, Uncaria, and Strychnos .

Cat. No.	Product Name	Chemical Structure

HY-23196S

Minoxidil-d10
Minoxidil-d₁₀ (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

HY-B0358AS

Flunarizine-d8 dihydrochloride
Flunarizine-d₈ dihydrochloride is deuterated labeled Flunarizine dihydrochloride (HY-B0358A). Flunarizine dihydrochloride is a potent dual Na ⁺/Ca ²⁺ channel (T-type) blocker. Flunarizine dihydrochloride is a D₂ dopamine receptor antagonist. Flunarizine dihydrochloride shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects .

HY-B0233S2

Isradipine-d7
Isradipine-d₇ is deuterated labeled Isradipine (HY-B0233). Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233S1

Isradipine-d6
Isradipine-d₆ is the deuterium labeled Isradipine . Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0233S

Isradipine-d3

Isradipine-d₃ (PN 200-110-d₃) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease .

HY-B0468S

Isoprenaline-d7 hydrochloride
Isoprenaline-d7 (hydrochloride) is a deuterated labeled Isoprenaline (hydrochloride) . Isoprenaline (Isoproterenol) hydrochloride is a non-selective, orally active β-adrenergic receptor agonist. Isoprenaline has potent peripheral vasodilator, bronchodilator, and cardiac stimulating activities. Isoprenaline can be used for the research of bradycardia and bronchial asthma .

HY-127026S

Quinaprilat-d5

Quinaprilat-d₅ is a deuterium-labeled Quinaprilat (HY-127026). Quinaprilat is a nonsulfhydryl ACE inhibitor, the active diacid metabolite of Quinapril. Quinaprilat specifically blocks the conversion of angiotensin I to the vasoconstrictor angiotensin II and inhibits bradykinin degradation. Quinaprilat primarily acts as a vasodilator, decreasing total peripheral and renal vascular resistance .

HY-B0131S

Prostaglandin E1-d4

Prostaglandin E1-d₄ is the deuterium labeled Prostaglandin E1. Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K_is of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inhibits platelet aggregation. Prostaglandin E1 can be used as a vasodilator for the research of peripheral vascular diseases .

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