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Xanthinol Nicotinate (Synonyms: Xanthinol Niacinate)

Cat. No.: HY-B1815 Purity: 99.83%
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Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance.

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Xanthinol Nicotinate Chemical Structure

Xanthinol Nicotinate Chemical Structure

CAS No. : 437-74-1

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Description

Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2].

In Vitro

Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2].
Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2].

Cell Proliferation Assay[2]

Cell Line: human umbilical artery smooth muscle cell (HUASMC)
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Inhibited HUASMC proliferation in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: HUASMC
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs.
In Vivo

Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration[1].
Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4)[1].

Animal Model: 5 week-old male NMRI mice[1]
Dosage: 75 mg/kg
Administration: IP
Result: Rapidly and transiently modified tumor pO2 and Maximal pO2 values were obtained 10 to 30 minutes after XN administration.
Molecular Weight

434.45

Formula

C₁₉H₂₆N₆O₆

CAS No.

437-74-1

SMILES

O=C(C1=CC=CN=C1)O.O=C(N2C)N(C)C3=C(N(CC(O)CN(CCO)C)C=N3)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (575.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3018 mL 11.5088 mL 23.0176 mL
5 mM 0.4604 mL 2.3018 mL 4.6035 mL
10 mM 0.2302 mL 1.1509 mL 2.3018 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Xanthinol NicotinateXanthinol NiacinateOthersvasodilatorsmoothmusclearteriescapillariesbloodvesselsrheologyperipheralvascularresistanceHUASMCInhibitorinhibitorinhibit

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