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Xanthinol Nicotinate (Synonyms: Xanthinol Niacinate)

Cat. No.: HY-B1815 Purity: 99.83%
Handling Instructions

Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance.

For research use only. We do not sell to patients.

Xanthinol Nicotinate Chemical Structure

Xanthinol Nicotinate Chemical Structure

CAS No. : 437-74-1

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Based on 1 publication(s) in Google Scholar

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Description

Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance[1][2].

In Vitro

Xanthinol Nicotinate (Xanthinol Niacinate; 2.76-276 µM; for 24 hours) inhibits HUASMC proliferation in a dose-dependent manner[2].
Xanthinol Nicotinate (2.76-276 µM; for 24 hours) dose-dependently decreases the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[2]

Cell Line: human umbilical artery smooth muscle cell (HUASMC)
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Inhibited HUASMC proliferation in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: HUASMC
Concentration: 2.76, 27.6 or 276 µM
Incubation Time: for 24 hours
Result: Dose-dependently decreased the PDGFR mRNA and PDGFR-β levels on the cell membranes of HUASMCs.
In Vivo

Xanthinol Nicotinate (Xanthinol Niacinate; 75 mg/kg; IP) rapidly and transiently modifies tumor pO2 and the maximal pO2 values are obtained 10 to 30 minutes after Xanthinol Nicotinate administration[1].
Xanthinol Nicotinate is able to radiosensitize the tumors when applying 10 Gy of X-Rays during the reoxygenation of the tumors (enhancement in radiation response of 1.4)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 week-old male NMRI mice[1]
Dosage: 75 mg/kg
Administration: IP
Result: Rapidly and transiently modified tumor pO2 and Maximal pO2 values were obtained 10 to 30 minutes after XN administration.
Molecular Weight

434.45

Formula

C₁₉H₂₆N₆O₆

CAS No.

437-74-1

SMILES

O=C(C1=CC=CN=C1)O.O=C(N2C)N(C)C3=C(N(CC(O)CN(CCO)C)C=N3)C2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 250 mg/mL (575.44 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3018 mL 11.5088 mL 23.0176 mL
5 mM 0.4604 mL 2.3018 mL 4.6035 mL
10 mM 0.2302 mL 1.1509 mL 2.3018 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Xanthinol NicotinateXanthinol NiacinateOthersvasodilatorsmoothmusclearteriescapillariesbloodvesselsrheologyperipheralvascularresistanceHUASMCInhibitorinhibitorinhibit

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