2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Benzcyclane

Benzcyclane  (Synonyms: Bencyclane; Benzcyclan)

Cat. No.: HY-U00134 Purity: 98.51%
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Benzcyclane (Bencyclane; Benzcyclan) is a serotonin receptor antagonist and a cerebral/peripheral vasodilator. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation.

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Benzcyclane

Benzcyclane Chemical Structure

CAS No. : 2179-37-5

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Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Other Forms of Benzcyclane:

Benzcyclane Related Antibodies

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Description

Benzcyclane (Bencyclane; Benzcyclan) is a serotonin receptor antagonist and a cerebral/peripheral vasodilator. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation[1].

In Vitro

Benzcyclane (0.0001-0.03 mg/mL; 2-3 minutes per concentration, 10-20 minutes for maximum relaxation) potently relaxes high K+-induced contractures in isolated rabbit basilar artery strips with an ED50 of 0.0011 mg/mL, producing faster and more marked relaxation than in mesenteric artery strips[1].
Benzcyclane (~30 minutes for maximum relaxation) relaxes high K+-induced contractures in isolated rabbit superior mesenteric artery strips with an ED50 of 0.0048 mg/mL, showing weaker and slower relaxation than in basilar artery strips[1].
Benzcyclane exerts the strongest antagonistic effect on serotonin-induced contractions in isolated rabbit superior mesenteric artery strips (presumptive pA2 = 7.3), with weaker noncompetitive antagonism of noradrenaline (pD2' = 4.3) and minimal effect on histamine (pD2' = 3.8)[1].
Benzcyclane (0.006 mg/mL, 0.01 mg/mL; 30 minutes for nerve stimulation, 20 minutes for noradrenaline) selectively inhibits 25 Hz sympathetic nerve-induced contractions in isolated rabbit pulmonary artery radial muscle preparations without affecting responses to exogenous noradrenaline[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benzcyclane Related Antibodies
Molecular Weight

289.46

Formula

C19H31NO
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CN(C)CCCOC1(CC2=CC=CC=C2)CCCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (345.47 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4547 mL 17.2735 mL 34.5471 mL
5 mM 0.6909 mL 3.4547 mL 6.9094 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.39%

SDS (394 KB)

COA (248 KB) HNMR (140 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4547 mL 17.2735 mL 34.5471 mL 86.3677 mL
5 mM 0.6909 mL 3.4547 mL 6.9094 mL 17.2735 mL
10 mM 0.3455 mL 1.7274 mL 3.4547 mL 8.6368 mL
15 mM 0.2303 mL 1.1516 mL 2.3031 mL 5.7578 mL
20 mM 0.1727 mL 0.8637 mL 1.7274 mL 4.3184 mL
25 mM 0.1382 mL 0.6909 mL 1.3819 mL 3.4547 mL
30 mM 0.1152 mL 0.5758 mL 1.1516 mL 2.8789 mL
40 mM 0.0864 mL 0.4318 mL 0.8637 mL 2.1592 mL
50 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7274 mL
60 mM 0.0576 mL 0.2879 mL 0.5758 mL 1.4395 mL
80 mM 0.0432 mL 0.2159 mL 0.4318 mL 1.0796 mL
100 mM 0.0345 mL 0.1727 mL 0.3455 mL 0.8637 mL
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Benzcyclane Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benzcyclane2179-37-5Bencyclane Benzcyclan5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorrabbit basilar arteriesnoradrenalinerabbit superior mesenteric arteriesdogvascular smooth musclesympathetic nerve stimulationmouserabbit pulmonary arteryserotonin receptorhistamineInhibitorinhibitorinhibit

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