2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. iGluR Sodium Channel Calcium Channel Potassium Channel
  4. Bupivacaine hydrochloride

Bupivacaine hydrochloride 

Cat. No.: HY-B0405A Purity: 99.92%
COA Handling Instructions

Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.

For research use only. We do not sell to patients.

Bupivacaine hydrochloride Chemical Structure

Bupivacaine hydrochloride Chemical Structure

CAS No. : 18010-40-7

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10 mM * 1 mL in DMSO USD 79 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Bupivacaine hydrochloride:

Bupivacaine hydrochloride Related Antibodies

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Description

Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain[1][2][3].

IC50 & Target

Sodium Channel[1]
In Vitro

Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization[1].
Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM[2].
Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 µM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bupivacaine hydrochloride Related Antibodies

Cell Viability Assay[3]

Cell Line: HEK 293 cells transfected with the SK2 gene (transfected cells were named SK2 cells)
Concentration: 10, 100, 1000 µM
Incubation Time:
Result: The IC50 value was 16.5 µM.
Clinical Trial
Molecular Weight

324.89

Appearance

Solid

Formula

C18H29ClN2O
CAS No.
SMILES

O=C(C1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (76.95 mM; Need ultrasonic)

H2O : 12.5 mg/mL (38.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0780 mL 15.3898 mL 30.7796 mL
5 mM 0.6156 mL 3.0780 mL 6.1559 mL
10 mM 0.3078 mL 1.5390 mL 3.0780 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 13 mg/mL (40.01 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.69 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Bupivacaine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Bupivacaine18010-40-7iGluRSodium ChannelCalcium ChannelPotassium ChannelIonotropic glutamate receptorsNa channelsNa+ channelsCa2+ channelsCa channelsKcsAelectrophysiologylocalanestheticsNMDApainchannelInhibitorinhibitorinhibit

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