2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. Methoxsalen

キサントトキシン  (Synonyms: Methoxsalen; 8-Methoxypsoralen; Xanthotoxin; 8-MOP)

製品番号: HY-30151 純度: 99.97%
COA 取扱説明書 Technical Support

Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Methoxsalen

キサントトキシン 構造式

CAS 番号 : 298-81-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 60 在庫あり
Solution
10 mM * 1 mL in DMSO USD 60 在庫あり
Solid
500 mg $55 在庫あり
1 g $79 在庫あり
5 g $135 在庫あり
10 g $220 在庫あり
25 g $350 在庫あり
50 g $490 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 17 publication(s) in Google Scholar

Other Forms of Methoxsalen:

キサントトキシン 関連抗体

Top Publications Citing Use of Products

Cytochrome P450 アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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  • 純度とドキュメンテーション

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製品説明

Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

Cellular Effect
Cell Line Type Value Description References
A-431 IC50
2.48 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
A-431 IC50
> 30 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
>30 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
2.48 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
A-431 IC50
25 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
25 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
> 30 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
25 3
Compound: 8-MOP
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human A431 cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
A-431 IC50
2.48 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against A 431 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
AGS IC50
>100 3
Compound: Xanthotoxin
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
[PMID: 28947149]
AGS IC50
> 100 3
Compound: Xanthotoxin
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
[PMID: 28947149]
AGS IC50
> 100 3
Compound: Xanthotoxin
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
Anti-proliferative activity against human AGS cells after 48 hrs by MTT assay
[PMID: 28947149]
HCT-116 IC50
> 100 3
Compound: 6
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 23746477]
HCT-116 IC50
>100 3
Compound: 6
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 23746477]
HeLa IC50
10 3
Compound: 8 -MOP
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) after exposure to UV light
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) after exposure to UV light
[PMID: 12930143]
HeLa IC50
> 30 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HeLa IC50
10 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HeLa IC50
>20 3
Compound: 8 -MOP
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) in dark condition
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) in dark condition
[PMID: 12930143]
HeLa IC50
3.16 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HeLa IC50
>20 3
Compound: 8-MOP
Antiproliferative activity against HeLa cells in dark
Antiproliferative activity against HeLa cells in dark
[PMID: 16821791]
HeLa IC50
7.6 6
Compound: Xanthotoxin
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
[PMID: 19217697]
HeLa IC50
10 3
Compound: 8-MOP
Antiproliferative activity against HeLa cells in presence of 0.789 J/cm2 UVA light
Antiproliferative activity against HeLa cells in presence of 0.789 J/cm2 UVA light
[PMID: 16821791]
HeLa IC50
>30 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HL-60 IC50
> 20 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
[PMID: 20615713]
HeLa IC50
10 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
HL-60 IC50
> 20 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
[PMID: 20615713]
HL-60 IC50
0.75 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HeLa IC50
7.6 6
Compound: Xanthotoxin
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
[PMID: 19217697]
HL-60 IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HeLa IC50
3.16 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HL-60 IC50
1.4 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HeLa IC50
10 3
Compound: 8-MOP
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HeLa cell line
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HeLa cell line
[PMID: 11965365]
HCT-116 IC50
> 100 3
Compound: 6
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 96 hrs by MTT assay
[PMID: 23746477]
HeLa IC50
10 2
Compound: 8-MOP (8-Methoxypsoralen)
In vitro antiproliferative activity against human cervix adenocarcinoma (HeLa) cells
In vitro antiproliferative activity against human cervix adenocarcinoma (HeLa) cells
[PMID: 10673096]
HL-60 IC50
5.4 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
[PMID: 20615713]
HT-1080 IC50
1.5 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HeLa IC50
10 3
Compound: 8-MOP
Photo-antiproliferative activity against human HeLa cells exposed to 365 nm, 0.793 Jcm'-2 UVA light
Photo-antiproliferative activity against human HeLa cells exposed to 365 nm, 0.793 Jcm'-2 UVA light
[PMID: 19359172]
HT-1080 IC50
1.9 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HeLa IC50
>20 3
Compound: 8-MOP
Photo-antiproliferative activity against human HeLa cells under dark condition
Photo-antiproliferative activity against human HeLa cells under dark condition
[PMID: 19359172]
HT-1080 IC50
2.1 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HeLa IC50
>20 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the dark
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the dark
[PMID: 10543884]
HL-60 IC50
0.75 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HeLa IC50
10 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the presence of UVA(ultra violet A irradiated)
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the presence of UVA(ultra violet A irradiated)
[PMID: 10543884]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
1.2 3
Compound: 8-MOP
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 3.2 joule/cm**2 UVA dose
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 3.2 joule/cm**2 UVA dose
[PMID: 15837311]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HL-60 IC50
5.4 3
Compound: 8 -MOP
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) after exposure to UV light
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) after exposure to UV light
[PMID: 12930143]
HT-29 IC50
> 100 3
Compound: 6
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
[PMID: 23746477]
HL-60 IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
>20 3
Compound: 8 -MOP
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) in dark condition
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) in dark condition
[PMID: 12930143]
HL-60 IC50
1.4 3
Compound: 8-MOP
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 2.5 joule/cm**2 UVA dose
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 2.5 joule/cm**2 UVA dose
[PMID: 15837311]
HL-60 IC50
>20 3
Compound: 8-MOP
Antiproliferative activity against HL60 cells in dark
Antiproliferative activity against HL60 cells in dark
[PMID: 16821791]
Jurkat IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 19230658]
HL-60 IC50
1.4 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
Jurkat IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
5.4 3
Compound: 8-MOP
Antiproliferative activity against HL60 cells in presence of 0.789 J/cm2 UVA light
Antiproliferative activity against HL60 cells in presence of 0.789 J/cm2 UVA light
[PMID: 16821791]
Jurkat IC50
1.2 3
Compound: 8MOP
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HL-60 IC50
5.4 2
Compound: 8-MOP (8-Methoxypsoralen)
In vitro antiproliferative activity against human promyelocytic (HL-60) cells
In vitro antiproliferative activity against human promyelocytic (HL-60) cells
[PMID: 10673096]
HL-60 IC50
0.75 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HL 60 cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HL-60 IC50
5.4 3
Compound: 8 -MOP
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) after exposure to UV light
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) after exposure to UV light
[PMID: 12930143]
K562 IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 19230658]
HL-60 IC50
5.4 3
Compound: 8-MOP
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HL-60 cell line
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HL-60 cell line
[PMID: 11965365]
HL-60 IC50
1.4 3
Compound: 8-MOP
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 2.5 joule/cm**2 UVA dose
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 2.5 joule/cm**2 UVA dose
[PMID: 15837311]
L02 IC50
> 100 3
Compound: Xanthotoxin
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
[PMID: 28947149]
HL-60 IC50
5.4 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the presence of UVA(ultra violet A irradiated)
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the presence of UVA(ultra violet A irradiated)
[PMID: 10543884]
HL-60 IC50
5.4 3
Compound: 8-MOP
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HL-60 cell line
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HL-60 cell line
[PMID: 11965365]
LoVo IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
[PMID: 19230658]
HL-60 IC50
1.2 3
Compound: 8-MOP
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 3.2 joule/cm**2 UVA dose
Cytotoxicity against HL-60 (human fibrosarcoma) cell line at 3.2 joule/cm**2 UVA dose
[PMID: 15837311]
HL-60 IC50
5.4 3
Compound: 8-MOP
Antiproliferative activity against HL60 cells in presence of 0.789 J/cm2 UVA light
Antiproliferative activity against HL60 cells in presence of 0.789 J/cm2 UVA light
[PMID: 16821791]
LoVo IC50
0.7 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
5.4 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
[PMID: 20615713]
HL-60 IC50
5.4 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
Cytotoxicity against human HL60 cells after 24 hrs by trypan blue assay in presence of 0.789 J cm-2 of UVA light
[PMID: 20615713]
LoVo IC50
0.7 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HL-60 IC50
>20 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
[PMID: 20615713]
HL-60 IC50
> 20 3
Compound: 8 -MOP
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) in dark condition
Antiproliferative activity against HL-60 (human promyelocytic leukemic cells) in dark condition
[PMID: 12930143]
HL-60 IC50
5.4 2
Compound: 8-MOP (8-Methoxypsoralen)
In vitro antiproliferative activity against human promyelocytic (HL-60) cells
In vitro antiproliferative activity against human promyelocytic (HL-60) cells
[PMID: 10673096]
LoVo IC50
1.1 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
1.1 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HL-60 IC50
1.4 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
> 20 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the dark
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the dark
[PMID: 10543884]
HL-60 IC50
> 20 3
Compound: 8-MOP
Antiproliferative activity against HL60 cells in dark
Antiproliferative activity against HL60 cells in dark
[PMID: 16821791]
MES-SA/Dx5 IC50
3.1 3
Compound: 6
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
[PMID: 23746477]
HL-60 IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HL-60 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
[PMID: 19230658]
HL-60 IC50
>20 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the dark
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the dark
[PMID: 10543884]
HL-60 IC50
> 20 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 24 hrs by trypan blue assay
[PMID: 20615713]
HL-60 IC50
> 20 3
Compound: 8-MOP
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
Cytotoxicity against human HL60 cells treated under dark condition after 72 hrs by trypan blue assay
[PMID: 20615713]
NCTC-2544 IC50
0.9 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HL-60 IC50
5.4 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the presence of UVA(ultra violet A irradiated)
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the presence of UVA(ultra violet A irradiated)
[PMID: 10543884]
HT-1080 IC50
1.5 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
NCTC-2544 IC50
5.5 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-1080 IC50
1.9 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HT-1080 IC50
2.1 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
NCTC-2544 IC50
5.5 3
Compound: 8MOP
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HT-1080 IC50
2.1 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 3.2 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
PAM212 IC50
> 100 3
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
[PMID: 30638875]
HT-1080 IC50
1.5 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 6.5 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
PAM212 IC50
> 100 3
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
[PMID: 30638875]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
Inhibition of cell growth after irradiation at UVA dose of 2.6 J/cmE-2 in HT1080 human fibrosarcoma cell line
[PMID: 12873520]
HT-1080 IC50
7.8 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
PAM212 IC50
0.1 3
Compound: 2; 8-MOP
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
[PMID: 30638875]
HT-1080 IC50
1.9 3
Compound: 8-MOP
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human HT1080 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HT-29 IC50
> 100 3
Compound: 6
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
[PMID: 23746477]
HT-29 IC50
>100 3
Compound: 6
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 96 hrs by MTT assay
[PMID: 23746477]
PANC-1 IC50
83.3 3
Compound: 6
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
[PMID: 23746477]
Jurkat IC50
>20 3
Compound: 8MOP
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 19230658]
Jurkat IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
Jurkat IC50
1.2 3
Compound: 8MOP
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
K562 IC50
>20 3
Compound: 8MOP
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 19230658]
HeLa IC50
10 2
Compound: 8-MOP (8-Methoxypsoralen)
In vitro antiproliferative activity against human cervix adenocarcinoma (HeLa) cells
In vitro antiproliferative activity against human cervix adenocarcinoma (HeLa) cells
[PMID: 10673096]
L02 IC50
>100 3
Compound: Xanthotoxin
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
[PMID: 28947149]
HeLa IC50
10 3
Compound: 8 -MOP
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) after exposure to UV light
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) after exposure to UV light
[PMID: 12930143]
LoVo IC50
>20 3
Compound: 8MOP
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
[PMID: 19230658]
HeLa IC50
10 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the presence of UVA(ultra violet A irradiated)
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the presence of UVA(ultra violet A irradiated)
[PMID: 10543884]
LoVo IC50
1.1 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 2.5 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 2.5 joule/cm**2 UVA dose
[PMID: 15837311]
HeLa IC50
10 3
Compound: 8-MOP
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HeLa cell line
Compound was evaluated for its antiproliferative activity after UVA irradiation on human tumor HeLa cell line
[PMID: 11965365]
LoVo IC50
0.7 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 3.2 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 3.2 joule/cm**2 UVA dose
[PMID: 15837311]
LoVo IC50
0.4 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 6.5 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 6.5 joule/cm**2 UVA dose
[PMID: 15837311]
HeLa IC50
10 3
Compound: 8-MOP
Antiproliferative activity against HeLa cells in presence of 0.789 J/cm2 UVA light
Antiproliferative activity against HeLa cells in presence of 0.789 J/cm2 UVA light
[PMID: 16821791]
HeLa IC50
10 3
Compound: 8-MOP
Photo-antiproliferative activity against human HeLa cells exposed to 365 nm, 0.793 Jcm'-2 UVA light
Photo-antiproliferative activity against human HeLa cells exposed to 365 nm, 0.793 Jcm'-2 UVA light
[PMID: 19359172]
LoVo IC50
1.1 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HeLa IC50
10 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells incubated for 1 hr with inhibitor followed by UV irradiation measured after 24 hrs by trypan blue dye assay
[PMID: 22537681]
LoVo IC50
0.7 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
1.1 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HeLa IC50
3.16 3
Compound: 8-MOP
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
Compound was evaluated for cell growth inhibition against HeLa cell line by irradiation in the presence of examined compound
[PMID: 8893844]
HeLa IC50
7.6 6
Compound: Xanthotoxin
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
Antitumor activity against human HeLa cells after 72 hrs by MTS assay
[PMID: 19217697]
LoVo IC50
0.7 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HeLa IC50
> 20 3
Compound: 8 -MOP
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) in dark condition
Antiproliferative activity against HeLa (human cervix adenocarcinoma cells) in dark condition
[PMID: 12930143]
MES-SA/Dx5 IC50
3.1 3
Compound: 6
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
[PMID: 23746477]
HeLa IC50
> 20 3
Compound: 8-MOP
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the dark
The compound was tested in vitro for growth inhibition against HeLa(human cervix adenocarcinoma) cell line in the dark
[PMID: 10543884]
NCTC-2544 IC50
>20 3
Compound: 8MOP
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
[PMID: 19230658]
HeLa IC50
> 20 3
Compound: 8-MOP
Antiproliferative activity against HeLa cells in dark
Antiproliferative activity against HeLa cells in dark
[PMID: 16821791]
NCTC-2544 IC50
5.5 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
HeLa IC50
> 20 3
Compound: 8-MOP
Photo-antiproliferative activity against human HeLa cells under dark condition
Photo-antiproliferative activity against human HeLa cells under dark condition
[PMID: 19359172]
NCTC-2544 IC50
0.9 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
5.5 3
Compound: 8MOP
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
HeLa IC50
> 30 3
Compound: 8-MOP
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
Antiproliferative activity against human HeLa cells after 24 hrs by trypan blue dye assay
[PMID: 22537681]
PAM212 IC50
>100 3
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
[PMID: 30638875]
PAM212 IC50
0.1 3
Compound: 2; 8-MOP
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
[PMID: 30638875]
Jurkat IC50
1.2 3
Compound: 8-MOP
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human JURKAT cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
PANC-1 IC50
83.3 3
Compound: 6
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
[PMID: 23746477]
Panel leukemia (Carcinoma cell lines) IC50
100 3
Compound: 1
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture irradiated at 366 nM
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture irradiated at 366 nM
[PMID: 8164263]
Jurkat IC50
1.2 3
Compound: 8MOP
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human Jurkat cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
Jurkat IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells after 72 hrs by MTT assay
[PMID: 19230658]
Panel leukemia (Carcinoma cell lines) IC50
>100 3
Compound: 1
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture under the dark conditions
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture under the dark conditions
[PMID: 8164263]
K562 IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Cytotoxicity against human K562 cells after 72 hrs by MTT assay
[PMID: 19230658]
Raji IC50
490 84
Compound: 7
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells
[PMID: 16441065]
L02 IC50
> 100 3
Compound: Xanthotoxin
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
Anti-proliferative activity against human L02 cells after 48 hrs by MTT assay
[PMID: 28947149]
LoVo IC50
0.4 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 6.5 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 6.5 joule/cm**2 UVA dose
[PMID: 15837311]
LoVo IC50
0.7 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 3.2 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 3.2 joule/cm**2 UVA dose
[PMID: 15837311]
LoVo IC50
0.7 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
0.7 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 3.75 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
LoVo IC50
1.1 3
Compound: 8-MOP
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 2.5 joule/cm**2 UVA dose
Cytotoxicity against LoVo (human intestinal adenocarcinoma) cell line at 2.5 joule/cm**2 UVA dose
[PMID: 15837311]
LoVo IC50
1.1 3
Compound: 8-MOP
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human LoVo cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
LoVo IC50
1.1 3
Compound: 8MOP
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human LoVo cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
LoVo IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
Cytotoxicity against human LoVo cells after 72 hrs by MTT assay
[PMID: 19230658]
MES-SA/Dx5 IC50
3.1 3
Compound: 6
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
Cytotoxicity against human MES-SA/Dx5 cells after 96 hrs by MTT assay
[PMID: 23746477]
NCTC-2544 IC50
0.9 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 3.75 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
5.5 3
Compound: 8-MOP
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
Photocytotoxicity against human NCTC 2544 cells treated 30 mins before 2.5 J/cm'2 UVA irradiation measured after 72 hrs by MTT assay
[PMID: 18951030]
NCTC-2544 IC50
5.5 3
Compound: 8MOP
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
Phototoxicity against human NCTC-2544 cells exposed to irradiation with 2.5 J/cm'2 UVA light prior to 72 hrs drug exposure by MTT assay
[PMID: 19230658]
NCTC-2544 IC50
> 20 3
Compound: 8MOP
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
Cytotoxicity against human NCTC-2544 cells after 72 hrs by MTT assay
[PMID: 19230658]
PAM212 IC50
0.1 3
Compound: 2; 8-MOP
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
Phototoxicity against mouse PAM212 cells assessed as cell growth inhibition preincubated for 30 mins followed by 1.28 J/cm2 UV light exposure and measured after 5 days by coulter counting method
[PMID: 30638875]
PAM212 IC50
> 100 3
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 30 mins under dark condition measured after 5 days by coulter counting method
[PMID: 30638875]
PAM212 IC50
> 100 3
Compound: 2; 8-MOP
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
Dark toxicity against mouse PAM212 cells assessed as cell growth inhibition incubated for 5 days under dark condition by coulter counting method
[PMID: 30638875]
PANC-1 IC50
83.3 3
Compound: 6
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
Cytotoxicity against human PANC1 cells after 96 hrs by MTT assay
[PMID: 23746477]
Panel leukemia (Carcinoma cell lines) IC50
100 3
Compound: 1
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture irradiated at 366 nM
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture irradiated at 366 nM
[PMID: 8164263]
Panel leukemia (Carcinoma cell lines) IC50
> 100 3
Compound: 1
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture under the dark conditions
In vitro photocytotoxicity is evaluated against human chronic myeloid leukemia cells grown in culture under the dark conditions
[PMID: 8164263]
Raji IC50
490 84
Compound: 7
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells
[PMID: 16441065]
体内実験

Methoxsalen (15mg/kg, i.p, single dose) increases nicotine’s Cmax prolongs the plasma nicotine half-life (fourfold increase), decreases its clearance (sixfold decrease), and increases its AUC[1].
Methoxsalen (15mg/kg, i.p, single dose) enhances the potency of pharmacological effects of oral nicotine (i.e., body temperature and analgesia)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult ICR mice[1]
Dosage: 15 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Increased nicotine plasma levels were still above 10ng/ml at 6hr.
Induced nicotine’s antinociceptive and hypothermic lasted close to 6 and 24 hr.
臨床実験
分子量

216.19

分子式

C12H8O4
CAS 番号
Appearance

Solid

Color

White to light yellow

SMILES

O=C1OC(C(C=C1)=C2)=C(OC)C3=C2C=CO3
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (231.28 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6256 mL 23.1278 mL 46.2556 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL
10 mM 0.4626 mL 2.3128 mL 4.6256 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション

純度: 99.98%

COA (252 KB) HNMR (115 KB) RP-HPLC (147 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.6256 mL 23.1278 mL 46.2556 mL 115.6390 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL 23.1278 mL
10 mM 0.4626 mL 2.3128 mL 4.6256 mL 11.5639 mL
15 mM 0.3084 mL 1.5419 mL 3.0837 mL 7.7093 mL
20 mM 0.2313 mL 1.1564 mL 2.3128 mL 5.7820 mL
25 mM 0.1850 mL 0.9251 mL 1.8502 mL 4.6256 mL
30 mM 0.1542 mL 0.7709 mL 1.5419 mL 3.8546 mL
40 mM 0.1156 mL 0.5782 mL 1.1564 mL 2.8910 mL
50 mM 0.0925 mL 0.4626 mL 0.9251 mL 2.3128 mL
60 mM 0.0771 mL 0.3855 mL 0.7709 mL 1.9273 mL
80 mM 0.0578 mL 0.2891 mL 0.5782 mL 1.4455 mL
100 mM 0.0463 mL 0.2313 mL 0.4626 mL 1.1564 mL
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Methoxsalen Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methoxsalen298-81-78-Methoxypsoralen Xanthotoxin 8-MOPCytochrome P450CYPsInhibitorinhibitorinhibit

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