1. Natural Products
  2. Alkaloids
  3. Pyridine Alkaloids

Pyridine Alkaloids

Pyridine Alkaloids (85):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B0150
    Nicotinamide 98-92-0 99.86%
    Nicotinamide is a form of vitamin B3 or niacin that inhibits sirtuin 2 (SIRT2) activity in vitro, with an EC50 of 2 μM. Nicotinamide inhibits up to 90% melanoma cell number and increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibts tumor growth in vivo and improves survival of melanoma-bearing mice, which can be used for the research of skin cancers such as melanoma.
  • HY-123033A
    Nicotinamide riboside chloride 23111-00-4 99.53%
    Nicotinamide riboside Chloride, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside Chloride reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease.
    Nicotinamide riboside chloride
  • HY-17024
    Cyclopamine 4449-51-8 99.97%
    Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
  • HY-N2329
    Piperlongumine 20069-09-4 98.09%
    Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome.
  • HY-N0414
    Trigonelline 535-83-1 99.98%
    Trigonelline, an alkaloid with potential antidiabetic activity, is present in Trigonella foenum-graecum L. Trigonelline is an efficient Nrf2 inhibitor capable of blocking Nrf2-dependent proteasome activity and thereby apoptosis protection in pancreatic cancer cells.
  • HY-N9194
    5-Methoxycanthin-6-one 15071-56-4
    5-Methoxycanthin-6-one is an orally active inhibitor of Leishmania strains. 5-Methoxycanthin-6-one shows cytotoxicity with an IC50 of 5.44 μg/mL against Ailanthus altissima cells.
  • HY-N9009
    1-Hydroxymethyl-β-carboline glucoside 1408311-12-5
    1-Hydroxymethyl-β-carboline glucoside (Compound 13) is a natural product that can be isolated from Picrasma quassioides.
    1-Hydroxymethyl-β-carboline glucoside
  • HY-N7153
    10-Hydroxycanthin-6-one 86293-41-6
    10-Hydroxycanthin-6-one is an antileukemic canthin-6-one alkaloid from Brucea antidysenterica. Antitumor agent.
  • HY-N2149
    Tomatidine 77-59-8 ≥98.0%
    Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans.
  • HY-100807
    Quinolinic acid 89-00-9 99.81%
    Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
    Quinolinic acid
  • HY-N0682
    Pyridoxine hydrochloride 58-56-0 99.92%
    Pyridoxine hydrochloride (Pyridoxol; Vitamin B6) is a pyridine derivative. Pyridoxine (Pyridoxol; Vitamin B6) exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway.
    Pyridoxine hydrochloride
  • HY-17387
    (-)-Huperzine A 102518-79-6 ≥98.0%
    (-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata, with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase (AChE), with an IC50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor. (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
    (-)-Huperzine A
  • HY-B1178
    Cotinine 486-56-6 99.71%
    Cotinine ((-)-Cotinine), an alkaloid in tobacco and a major metabolite of nicotine, is used as a biological indicator to measure the composition of tobacco smoke
  • HY-W052144
    (±) Anabasine 13078-04-1
    (±) Anabasine is a biphasic muscle relaxant.
    (±) Anabasine
  • HY-B1532
    Anabasine 494-52-0 98.86%
    Anabasine ((S)-Anabasine) is an alkaloid that found as a minor component in tobacco (Nicotiana). Anabasine is a botanical pesticide nicotine, acts as a full agonist of nicotinic acetylcholine receptors (nAChRs). Anabasine induces depolarization of TE671 cells endogenously expressing human fetal muscle-type nAChRs (EC50=0.7 µM).
  • HY-B0979
    Lobeline hydrochloride 134-63-4 99.97%
    Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
    Lobeline hydrochloride
  • HY-124124
    N-Methylnicotinamide 114-33-0 ≥98.0%
    N-Methylnicotinamide is an endogenous metabolite.
  • HY-N2079
    (-)-Securinine 5610-40-2 ≥98.0%
    (-)-Securinine is plant-derived alkaloid and also a GABAA receptor antagonist.
  • HY-N0415
    Trigonelline chloride 6138-41-6 99.88%
    Trigonelline chloride, an alkaloid with potential antidiabetic activity, is present in considerable amounts in Leonurus artemisia. Trigonelline chloride has anti-HSV-1 , antibacterial, and antifungal activities.
    Trigonelline chloride
  • HY-117025A
    Manzamine A hydrochloride 104264-80-4 99.29%
    Manzamine A hydrochloride, an orally active beta-carboline alkaloid, inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride has antimalarial and anticancer activities. Manzamine A hydrochloride also shows potent activity against HSV-1.
    Manzamine A hydrochloride