2. Metabolic Enzyme/Protease
  3. MMP
  4. SB-3CT

SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity.

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CAS 番号 : 292605-14-2

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>無料サンプル (0.1 - 0.2 mg)   今すぐ申し込む  
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 130 在庫あり
Solution
10 mM * 1 mL in DMSO USD 130 在庫あり
Solid
5 mg $119 在庫あり
10 mg $198 在庫あり
25 mg $340 在庫あり
50 mg $495 在庫あり
100 mg $740 在庫あり
500 mg $1440 在庫あり
1 g   お問い合わせ  
5 g   お問い合わせ  

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カスタマーレビュー

Based on 26 publication(s) in Google Scholar

Other Forms of SB-3CT:

SB-3CT 関連抗体

Top Publications Citing Use of Products

    SB-3CT purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2023 Apr 10;41(4):757-775.e10.  [Abstract]

    SB-3CT (MMP9 inh.; 50 mg/kg/day; i.v.; 2 weeks) counteracts NET(neutrophil extracellular trap)-mediated EMT(epithelial-mesenchymal transition) in mice.

    SB-3CT purchased from MedChemExpress. Usage Cited in: Mol Cell Probes. 2020 Apr;50:101498.  [Abstract]

    Expression of MMP-9 in circulating M-MDSCs from tumor bearing mice with or without stimulation of the MMP-9 inhibitor SB-3CT.

    SB-3CT purchased from MedChemExpress. Usage Cited in: Neuroscience. 2018 May 1:377:126-137.  [Abstract]

    To confirm the critical role of MMP-2/-9 and autophagy in OGD/R induced ZO-1 redistribution and reduction, the effects of MMP-2/9 inhibitor (SB-3CT) and autophagy inhibitor (3-MA) are examined on the endothelial barrier function and ZO-1 degradation.

    MMP アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 MMP-19

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with Ki values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity[1][2][3].

    IC50 & Target[1]

    MMP-2

    13.9 nM (Ki)

    MMP-9

    600 nM (Ki)

    体外実験

    SB-3CT has shown efficacy in an animal model of severe traumatic brain injury (TBI). SB-3CT inhibits MMP-9 with an inhibition constant Ki of 400±15 nM[1].
    Inhibition of PC3 tumor growth by SB-3CT could also be a direct consequence of reduced extracellular matrix degradation within the bone tissue by the tumor cells themselves and/or by osteoclasts. Indeed, SB-3CT treatment is associated with a reduced osteolytic response, indicating that SB-3CT helps to preserve bone integrity[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SB-3CT 関連抗体
    体内実験

    SB-3CT (i.p.; 50 mg/kg; every other day; five weeks) inhibits intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Five-week-old male C.B.-17.SCID mice[3]
    Dosage: 50 mg/kg
    Administration: IP; every other day; five weeks
    Result: Inhibited intraosseous growth of human PC3 cells within the marrow of human fetal femur fragments previously implanted in SCID mice.
    分子量

    306.40

    分子式

    C15H14O3S2
    CAS 番号
    Appearance

    Solid

    Color

    White to pink

    SMILES

    O=S(CC1SC1)(C2=CC=C(OC3=CC=CC=C3)C=C2)=O
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    -20°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    DMSO : ≥ 50 mg/mL (163.19 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2637 mL 16.3185 mL 32.6371 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
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    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (8.16 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.84%

    COA (247 KB) HNMR (428 KB) RP-HPLC (244 KB) LCMS (95 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2637 mL 16.3185 mL 32.6371 mL 81.5927 mL
    5 mM 0.6527 mL 3.2637 mL 6.5274 mL 16.3185 mL
    10 mM 0.3264 mL 1.6319 mL 3.2637 mL 8.1593 mL
    15 mM 0.2176 mL 1.0879 mL 2.1758 mL 5.4395 mL
    20 mM 0.1632 mL 0.8159 mL 1.6319 mL 4.0796 mL
    25 mM 0.1305 mL 0.6527 mL 1.3055 mL 3.2637 mL
    30 mM 0.1088 mL 0.5440 mL 1.0879 mL 2.7198 mL
    40 mM 0.0816 mL 0.4080 mL 0.8159 mL 2.0398 mL
    50 mM 0.0653 mL 0.3264 mL 0.6527 mL 1.6319 mL
    60 mM 0.0544 mL 0.2720 mL 0.5440 mL 1.3599 mL
    80 mM 0.0408 mL 0.2040 mL 0.4080 mL 1.0199 mL
    100 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8159 mL
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    SB-3CT Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SB-3CT292605-14-2MMPMatrix metalloproteinasesmatrixmetalloproteinaseMMP-2MMP-9gelatinasesblood-brainbarrierpermeabilityneuroprotectiveeffectsanticancerInhibitorinhibitorinhibit

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    製品名:
    SB-3CT
    製品番号:
    HY-12354
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