2. Metabolic Enzyme/Protease Neuronal Signaling Membrane Transporter/Ion Channel
  3. Endogenous Metabolite GlyT
  4. Sarcosine

サルコシン  (Synonyms: Sarcosine; N-Methylglycine; Sarcosin)

製品番号: HY-101037 純度: 98.0%
COA 取扱説明書 Technical Support

Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.

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Sarcosine

サルコシン 構造式

CAS 番号 : 107-97-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 在庫あり
Solution
10 mM * 1 mL in Water USD 33 在庫あり
Solid
100 mg $30 在庫あり
500 mg $50 在庫あり
1 g $60 在庫あり
5 g $90 在庫あり
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* アイテムを追加する前、数量をご選択ください

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Based on 3 publication(s) in Google Scholar

Other Forms of Sarcosine:

サルコシン 関連抗体

Top Publications Citing Use of Products

Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

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Human Endogenous Metabolite Microbial Metabolite

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GlyT1 GlyT2

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  • 純度とドキュメンテーション

  • 参考文献

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製品説明

Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

IC50 & Target

GlyT1

 

Human Endogenous Metabolite

 

体内実験

Sarcosine (400-800mg/kg; i.p.) significantly raises the threshold for electroconvulsions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Albino Swiss mice weighing (25-30 g)[2]
Dosage: 100 mg/kg, 200 mg/kg, 400 mg/kg, 800 mg/kg
Administration: Intraperitoneal injection
Result: Elevated the seizure threshold at doses of 400 mg/kg and 800 mg/kg in the MEST test in mice.
臨床実験
分子量

89.09

分子式

C3H7NO2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CNC
Structure Classification
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature 3 years

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature 3 years)
溶剤 & 溶解度
体外: 

H2O : 100 mg/mL (1122.46 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.2246 mL 56.1230 mL 112.2460 mL
5 mM 2.2449 mL 11.2246 mL 22.4492 mL
10 mM 1.1225 mL 5.6123 mL 11.2246 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (1122.46 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 98.0%

COA (243 KB) HNMR (221 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.2246 mL 56.1230 mL 112.2460 mL 280.6151 mL
5 mM 2.2449 mL 11.2246 mL 22.4492 mL 56.1230 mL
10 mM 1.1225 mL 5.6123 mL 11.2246 mL 28.0615 mL
15 mM 0.7483 mL 3.7415 mL 7.4831 mL 18.7077 mL
20 mM 0.5612 mL 2.8062 mL 5.6123 mL 14.0308 mL
25 mM 0.4490 mL 2.2449 mL 4.4898 mL 11.2246 mL
30 mM 0.3742 mL 1.8708 mL 3.7415 mL 9.3538 mL
40 mM 0.2806 mL 1.4031 mL 2.8062 mL 7.0154 mL
50 mM 0.2245 mL 1.1225 mL 2.2449 mL 5.6123 mL
60 mM 0.1871 mL 0.9354 mL 1.8708 mL 4.6769 mL
80 mM 0.1403 mL 0.7015 mL 1.4031 mL 3.5077 mL
100 mM 0.1122 mL 0.5612 mL 1.1225 mL 2.8062 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Sarcosine Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sarcosine107-97-1N-Methylglycine SarcosinEndogenous MetaboliteGlyTGlycine transportersdepressionschizophreniacognitivedysfunctionInhibitorinhibitorinhibit

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