1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Adrenergic Receptor
  3. Urapidil

Urapidil 

Cat. No.: HY-B0716 Purity: 99.89%
Handling Instructions

Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

For research use only. We do not sell to patients.

Urapidil Chemical Structure

Urapidil Chemical Structure

CAS No. : 34661-75-1

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50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

Other Forms of Urapidil:

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Description

Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.

IC50 & Target

α1 adrenoreceptor, 5-HT1A receptor[1]

In Vitro

Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist. Urapidil does not affect vascular tone at concentrations up to 10-5 M. Urapidil (10-5 M) markedly inhibits the alpha 1-adrenergic agonist (phenylephrine)-induced concentration-dependent contractions in aortic rings without endothelium and also to some extent in those with endothelium. Moreover, the inhibitory effect of Urapidil is more pronounced in rings without endothelium than in those with endothelium. Urapidil (10-5 M) affects neither the vascular tone nor the concentration-dependent contraction to serotonin[1].

Clinical Trial
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : < 0.1 mg/mL (insoluble)

References
Cell Assay

The rat aorta is placed in Krebs solution and stripped of connective tissue, then subsequently cut into rings (2 to 3 mm in length). As indicated, the endothelium is removed by rubbing the intimal surface of rings with a pair of forceps. The rings are suspended in organ baths containing oxygenated (95% O2 and 5% CO2) Krebs bicarbonate solution. Following equilibration for 90 min under a resting tension of 2 g, the rings are contracted with KCl (80 mM) to assess their reactivity. After a 30-min washout period, the rings are contracted with the α1-adrenergic receptor agonist phenylephrine (10-6 M) to about 80% of the maximal contraction before addition of acetylcholine (10-6 M) to check for the presence of a functional endothelium. After a 30-min equilibration period, the rings with or without endothelium are exposed to Urapidil (10-5 M) for 25 min before inducing a concentration-contraction curve to phenylephrine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

387.48

Formula

C₂₀H₂₉N₅O₃

CAS No.

34661-75-1

SMILES

O=C1N(C)C(C=C(NCCCN2CCN(C3=CC=CC=C3OC)CC2)N1C)=O

Shipping

Room temperature in continental US; may vary elsewhere

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Urapidil
Cat. No.:
HY-B0716
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Urapidil

Cat. No.: HY-B0716