Urapidil-d4
Urapidil-d4 is the deuterium labeled Urapidil. Urapidil is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.
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- CAS No.: 1795122-12-1
- Formule: C20H25D4N5O3
- Masse moléculaire:391.50
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Adrenergic Receptor
MoreVoir tous les produits spécifiques à Isoform 5-HT Receptor
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Activité biologique
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5-HT1A Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1795122-12-1
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Unlabeled Cas 34661-75-1
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Masse moléculaire 391.50
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Formule C20H25D4N5O3
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SMILES
COC1=C(N2CC([2H])([2H])N(C([2H])([2H])C2)CCCNC(N(C(N3C)=O)C)=CC3=O)C=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
DMSO : 25 mg/mL (63.86 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Références
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Bopp C, et al. The effect of urapidil, an alpha-1 adrenoceptor antagonist and a 5-HT1A agonist, on the vascular tone of the porcine coronary and pulmonary arteries, the rat aorta and the human pulmonary artery. Eur J Pharmacol. 2016 May 15;779:53-8. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5543 mL | 12.7714 mL | 25.5428 mL | 63.8570 mL |
| 5 mM | 0.5109 mL | 2.5543 mL | 5.1086 mL | 12.7714 mL | |
| 10 mM | 0.2554 mL | 1.2771 mL | 2.5543 mL | 6.3857 mL | |
| 15 mM | 0.1703 mL | 0.8514 mL | 1.7029 mL | 4.2571 mL | |
| 20 mM | 0.1277 mL | 0.6386 mL | 1.2771 mL | 3.1928 mL | |
| 25 mM | 0.1022 mL | 0.5109 mL | 1.0217 mL | 2.5543 mL | |
| 30 mM | 0.0851 mL | 0.4257 mL | 0.8514 mL | 2.1286 mL | |
| 40 mM | 0.0639 mL | 0.3193 mL | 0.6386 mL | 1.5964 mL | |
| 50 mM | 0.0511 mL | 0.2554 mL | 0.5109 mL | 1.2771 mL | |
| 60 mM | 0.0426 mL | 0.2129 mL | 0.4257 mL | 1.0643 mL |
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