2. Others Neuronal Signaling Metabolic Enzyme/Protease Anti-infection Apoptosis Stem Cell/Wnt
  3. Fungal Notch Environmental Pollutants Bacterial Endogenous Metabolite Apoptosis
  4. Carvacrol

カルバクロール  (Synonyms: Carvacrol; Cymophenol)

製品番号: HY-N0711 純度: 99.96%
COA 取扱説明書 Technical Support

Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 499-75-2

容量 価格（税別） 在庫状況 数量
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 在庫あり
Solution
10 mM * 1 mL in DMSO USD 55 在庫あり
Liquid
100 mg $50 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 10 publication(s) in Google Scholar

Other Forms of Carvacrol:

カルバクロール 関連抗体

Top Publications Citing Use of Products

    Carvacrol purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2025 Sep 29:16:1671461.  [Abstract]

    Representative images of DRG neurons in response to 100 μM Carvacrol and 100 μM AITC after pretreatment with vehicle, DMI (100 μM), or DMI + HC-030031 (100 μM).

    Carvacrol purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 May 26:58:102431.  [Abstract]

    The shortening of colon length, indicative of colitis severity induced by DSS, was significantly alleviated in the Carvacrol group.

    Carvacrol purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 May 26:58:102431.  [Abstract]

    Carvacrol markedly reduced the histopathological damage in DSS-induced colitis.

    Carvacrol purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 May 26:58:102431.  [Abstract]

    Tissue immunohistochemistry results showed a reduction in MUC2 expression in DSS-induced colitis mice, which was significantly restored by Carvacrol treatment.

    Carvacrol purchased from MedChemExpress. Usage Cited in: Transl Oncol. 2025 May 26:58:102431.  [Abstract]

    qPCR analysis revealed that the expression levels of ZO-1, Claudin3, Claudin1, Occludin, and Mucin were significantly increased in the Carvacrol group compared to the DSS group.

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Carvacrol is an orally active and blood-brain barrier-permeable monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations[1][2].

    Cellular Effect
    Cell Line Type Value Description References
    HEK293 EC50
    17 μM
    Compound: Carvacrol
    Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
    Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay
    		[PMID: 30878828]
    HEK293 EC50
    7 μM
    Compound: 24
    Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx
    Agonist activity at human TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx
    		[PMID: 20356305]
    体内実験

    Carvacrol (50 or 100 mg/kg; i.p.) inhibits the mechanical hyper-nociception induced by carrageenan in mice[2].
    Carvacrol (20, 40, and 80 mg/kg, intragastric gavage, during six days before LPS injection) reduces inflammation (reduces serum proinflammatory molecules) in rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    150.22

    分子式

    C10H14O
    CAS 番号
    Appearance

    Liquid (Density: 0.976 g/cm3)

    Color

    Colorless to light yellow

    SMILES

    OC1=CC(C(C)C)=CC=C1C
    Structure Classification
    Initial Source
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Pure form -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (665.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 6.6569 mL 33.2845 mL 66.5690 mL
    5 mM 1.3314 mL 6.6569 mL 13.3138 mL
    10 mM 0.6657 mL 3.3285 mL 6.6569 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

    ×
    体積 （終了）

    V2

    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (16.64 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション

    純度: 99.98%

    COA (246 KB) HNMR (131 KB) GC (243 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 6.6569 mL 33.2845 mL 66.5690 mL 166.4226 mL
    5 mM 1.3314 mL 6.6569 mL 13.3138 mL 33.2845 mL
    10 mM 0.6657 mL 3.3285 mL 6.6569 mL 16.6423 mL
    15 mM 0.4438 mL 2.2190 mL 4.4379 mL 11.0948 mL
    20 mM 0.3328 mL 1.6642 mL 3.3285 mL 8.3211 mL
    25 mM 0.2663 mL 1.3314 mL 2.6628 mL 6.6569 mL
    30 mM 0.2219 mL 1.1095 mL 2.2190 mL 5.5474 mL
    40 mM 0.1664 mL 0.8321 mL 1.6642 mL 4.1606 mL
    50 mM 0.1331 mL 0.6657 mL 1.3314 mL 3.3285 mL
    60 mM 0.1109 mL 0.5547 mL 1.1095 mL 2.7737 mL
    80 mM 0.0832 mL 0.4161 mL 0.8321 mL 2.0803 mL
    100 mM 0.0666 mL 0.3328 mL 0.6657 mL 1.6642 mL
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    Carvacrol Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Carvacrol499-75-2CymophenolFungalNotchEnvironmental PollutantsBacterialEndogenous MetaboliteApoptosisEnvironmental Contaminantsantioxidantantibacterialantifungalanticanceranti-inflammatoryhepatoprotectivespasmolyticvasorelaxantInhibitorinhibitorinhibit

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    製品名:
    Carvacrol
    製品番号:
    HY-N0711
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