C7 - complement C7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 730

About C7

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,909,497-40,984,643 (from NCBI)

This gene has 9 transcripts (splice variants), 249 orthologues, 39 paralogues and is associated with 2 phenotypes. Broad expression in adrenal (RPKM 552.9), gall bladder (RPKM 224.3) and 14 other tissues.

Summary

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and Bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]

C7 Products (1)

mRNA Protein Name
NM_000587.4 NP_000578.2 complement component C7 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of membrane attack complex IDA
IDA: Inferred from direct assay
22832194 GOA
part of membrane attack complex IPI
IPI: Inferred from physical interaction
30552328 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C7 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (34 - 79)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (85 - 119)

MACPF

MACPF: MAC/Perforin domain (229 - 448)

TSP_1

TSP_1: Thrombospondin type 1 domain (503 - 548)

Sushi

Sushi: Sushi repeat (SCR repeat) (571 - 619)

Sushi

Sushi: Sushi repeat (SCR repeat) (637 - 683)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 843 a.a.
Protein Preferred Names Protein Names

complement component C7

  • complement component 7

Recombinant C7 Proteins

Cat. No. Product Name Accession Purity
HY-P74371 C7/Complement component C7 Protein, Human (HEK293, His, solution) P10643 (S23-Q843) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74372 C7/Complement component C7 Protein, Human (HEK293, Fc) P10643 (S23-Q843) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Complement Component 7 Deficiency

  • C7 Deficiency

  • C7D
Immunodeficiency Due To A Late Component Of Complement Deficiency

  • Immunodeficiency Due To C5 To C9 Component Complement Deficiency

  • Terminal Complement Pathway Deficiency
Meningococcal Meningitis

  • Meningitis, Meningococcal

  • Meningitis Meningococcal

  • Epidemic Meningitis

  • Meningitis Due To Neisseria Meningitidis

  • Meningococcal Meninges Infection

  • Meningococcal Meningeal Infection

  • Meningococcal Cerebrospinal Inflammation

  • Chronic Meningococcal Arachnoiditis

  • Meningococcal Arachnoiditis

  • Diplococcal Spinal Meningitis

  • Diplococcal Meningitis

  • Meningococcal Cerebrospinal Fever

  • Meningococcal Cerebrospinal Infection

  • Meningococcal Spinal Meningitis
Pyoderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9934 Abciximab Inhibitor 99.97% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-N0216S6 Benzoic acid-13C7 Inhibitor / Phase 2

Pre-clinical Phase

Bioactive Molecules (103)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150745A ODN 24987 sodium 99.08% Unkown
HY-W016103 1-Hydroxy-2-naphthoic acid 99.70% Unkown
HY-W088194 Boc-C7-COOH / Unkown
HY-W668775 Quin-C7 Antagonist 99.76% Unkown
HY-148671 (S,R,S)-AHPC-amido-C7-acid 98.71% Unkown
HY-150746A ODN 24991 sodium 99.64% Unkown
HY-161766 L687 Activator 99.49% Unkown
HY-W008821 1,7-Heptanediamine Inhibitor ≥98.0% Unkown
HY-149577 EBV lytic cycle inducer-1 Inducer 96.25% Unkown
HY-147128 PY109 Agonist 99.15% Unkown
HY-P10501A FRα-targeting peptide C7 TFA 99.85% Unkown
HY-133799 Pomalidomide-C7-COOH 95.35% Unkown
HY-136005 VH032-C7-COOH 99.92% Unkown
HY-150746 ODN 24991 Inhibitor 99.64% Unkown
HY-B0315S Vitamin B12-13C7 96.14% Unkown
HY-P3801 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) Modulator 99.61% Unkown
HY-W012340S L-Homoarginine-13C7,15N4 hydrochloride 98.0% Unkown
HY-130640 (S,R,S)-AHPC-Me-C7 ester 95.49% Unkown
HY-131874 Thalidomide-O-C7-acid Inducer 98.55% Unkown
HY-131878 Pomalidomide-C7-NH2 hydrochloride 98.97% Unkown
HY-150745 ODN 24987 Inhibitor / Unkown
HY-163678 Pomalidomide-CO-C7-NH-CO-C3-COOH 98.55% Unkown
HY-16676 7-Epi-docetaxel Activator 98.76% Unkown
HY-176224 Anti-virulence factor-IN-2 Inhibitor 98.41% Unkown
HY-P10501 FRα-targeting peptide C7 / Unkown
HY-RS03384 CXCL10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011103 Diheptyl phthalate 98.64% Unkown
HY-W016087 Monoethyl pimelate / Unkown
HY-130949B Thalidomide-4-O-C7-NH2 hydrochloride 99.80% Unkown
HY-N6802 Tigloylgomisin H Inducer 98.37% Unkown
HY-130949 Thalidomide-4-O-C7-NH2 Inducer / Unkown
HY-128746S 2,6-Diaminoheptanedioic acid-13C7,15N2 / Unkown
HY-131622S 7-Aminoclonazepam-13C6 / Unkown
HY-131740 2'-Deoxytubercidin 5'-triphosphate / Unkown
HY-131740A 2'-Deoxytubercidin 5'-triphosphate sodium / Unkown
HY-136186 (S,R,S)-AHPC-C7-amine / Unkown
HY-136186B (S,R,S)-AHPC-C7-amine hydrochloride / Unkown
HY-149564 Thalidomide-5-O-C7-NH2 hydrochloride Inducer 98.13% Unkown
HY-149645 CB2 receptor antagonist 2 Antagonist / Unkown
HY-151274 SARS-CoV-2-IN-28 Inhibitor / Unkown
HY-151274A SARS-CoV-2-IN-28 disodium Inhibitor / Unkown
HY-151468 AIE-Cbz-LD-C7 / Unkown
HY-153541 AP-C7 Inhibitor / Unkown
HY-155263 Pomalidomide-5-C7-NH2 hydrochloride / Unkown
HY-155527 SARS-CoV-2 Mpro-IN-9 Inhibitor 99.31% Unkown
HY-155560 Pomalidomide-C7-NH2 / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-157883 C7BzO Inhibitor / Unkown
HY-161379 CLZX-205 Inhibitor / Unkown
HY-161663 Phosphodiesterase-IN-2 Inhibitor / Unkown
HY-161933 1-Adamantane-amide-C7-NH2 / Unkown
HY-163758 COOH-C3-CONH-C7-COOH / Unkown
HY-163984 Antibacterial agent 240 Inhibitor / Unkown
HY-164799 FXR agonist 12 Agonist / Unkown
HY-167694 Antiproliferative agent-62 Activator / Unkown
HY-169006 Evo312 / Unkown
HY-173580 7-Deaza-2'-deoxyadenosine-5'-O-triphosphate tetrasodium / Unkown
HY-174869 Pomalidomide-5-C7-NH2 / Unkown
HY-175241 T-01-C7-amide / Unkown
HY-176470 Thalidomide-N-C-piperidine-C7-Br / Unkown
HY-179720 TT-012-NH-C7-NHBoc / Unkown
HY-181189 Lenalidomide-C7-NH2 / Unkown
HY-181868 Lenalidomide-CO-C7-NH2 / Unkown
HY-181882 MV78-OH-C7-COOH / Unkown
HY-186154 Thalidomide-amine-C7-acid / Unkown
HY-187177 Pomalidomide-C2-NHCO-C7-NHBoc / Unkown
HY-CE01248 C7:0-CoA / Unkown
HY-E71528 2-epi-5-epi-Valiolone synthase / Unkown
HY-N10344 Glucoarabin Activator / Unkown
HY-N19150 Cordybislactone hydrolyzed derivative-1 / Unkown
HY-N6779S Patulin-13C7 / Unkown
HY-N7777 7-Xylosyl-10-Deacetyltaxol C / Unkown
HY-P3972 H-ILE-ARG-VAL-VAL-MET-OH / Unkown
HY-RS01753 C7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01754 C7orf50 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05971 H3C7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12598 SDR9C7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W142432S Perfluoroundecanoic acid-13C7 / Unkown
HY-W334800S (2S,6S)-2,6-Diaminoheptanedioic acid-13C7,15N2 / Unkown
HY-W334800S2 (2S,6S)-2,6-Diaminoheptanedioic acid-13C7 / Unkown
HY-W753671 2,6-Diaminoheptanedioic acid-13C7 / Unkown
HY-W767186 D-Mannoheptulose-13C7 / Unkown
HY-W940797 Thalidomide-O-amido-C7-NH2 / Unkown
HY-Y1027S 2-Chlorobenzoic Acid-13C7 / Unkown
HY-100807S1 Quinolinic acid-13C7 / Unkown
HY-103447S2 Zearalenone-13C7 Activator / Unkown
HY-118051 LY 186826 / Unkown
HY-136186A (S,R,S)-AHPC-C7-amine dihydrochloride / Unkown
HY-14283S Luliconazole-13C7 / Unkown
HY-159204 3'-Amino-Modifier C7 CPG 1000 / Unkown
HY-162862 JAK-IN-38 / Unkown
HY-180442 7-BioQ / Unkown
HY-181356 (S,R,S,R)-AHPC-Me-CO-C7-N3 / Unkown
HY-185909 Dodecanamido C7 Phosphoramidite / Unkown
HY-185910 Palmitamido C7 Phosphoramidite / Unkown
HY-B0495S8 Lamotrigine-13C7,15N / Unkown
HY-RS16518 Cxcl10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17240 C7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20317 Oxr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23694 C7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W278073 RNA splicing modulator 6 Modulator / Unkown
HY-W800743 Heptyl 6-bromohexanoate / Unkown
HY-W939883 Thalidomide-4-O-C7-Br / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991608 CTM01 Inhibitor / Unkown
HY-P991573 Anti-EGFR Antibody (D2C7) Inhibitor / Unkown
HY-P991857 Anti-Human/Mouse/Bovine ADAM10 Antibody (8C7) / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus C7 MGD MGI:88235
Felis catus C7 VGNC VGNC:60234
Macaca mulatta C7 VGNC VGNC:70478
Rattus norvegicus C7 RGD RGD:620318
Canis familiaris C7 VGNC VGNC:38599
Bos taurus C7 VGNC VGNC:26643
Others C7 NCBI