2. Gene
  3. C7 - complement C7 Gene

C7 - complement C7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 730 | Gene type: protein coding

About C7

Cytogenetic location: 5p13.1 Genomic coordinates (GRCh38): 5:40,909,497-40,984,643 (from NCBI)

This gene has 9 transcripts (splice variants), 249 orthologues, 39 paralogues and is associated with 2 phenotypes. Broad expression in adrenal (RPKM 552.9), gall bladder (RPKM 224.3) and 14 other tissues.

Summary

This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and Bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]

C7 Products(1)

mRNA Protein Name
NM_000587.4 NP_000578.2 complement component C7 precursor

C7 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (34 - 79)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (85 - 119)

MACPF

MACPF: MAC/Perforin domain (229 - 448)

TSP_1

TSP_1: Thrombospondin type 1 domain (503 - 548)

Sushi

Sushi: Sushi repeat (SCR repeat) (571 - 619)

Sushi

Sushi: Sushi repeat (SCR repeat) (637 - 683)

  • 0
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  • 843 a.a.
Protein Preferred Names Protein Names

complement component C7

complement component 7

Recombinant C7 Proteins

Cat. No. Product Name Accession Purity
HY-P74371 C7/Complement component C7 Protein, Human (HEK293, His) P10643 (M1-Q843) ≥95%
HY-P74372 C7/Complement component C7 Protein, Human (HEK293, Fc) P10643 (M1-Q843) ≥95%

Related Diseases

Diseases Alias
Complement Component 7 Deficiency

C7 Deficiency

C7D
Immunodeficiency Due To A Late Component Of Complement Deficiency

Immunodeficiency Due To C5 To C9 Component Complement Deficiency

Terminal Complement Pathway Deficiency
Meningococcal Meningitis

Meningitis, Meningococcal

Meningitis Meningococcal

Epidemic Meningitis

Meningitis Due To Neisseria Meningitidis

Meningococcal Meninges Infection

Meningococcal Meningeal Infection

Meningococcal Cerebrospinal Inflammation

Chronic Meningococcal Arachnoiditis

Meningococcal Arachnoiditis

Diplococcal Spinal Meningitis

Diplococcal Meningitis

Meningococcal Cerebrospinal Fever

Meningococcal Cerebrospinal Infection

Meningococcal Spinal Meningitis
Pyoderma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9934 Abciximab Inhibitor 99.966% Unkown
Pre-clinical Phase
Bioactive Molecules (45)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133799 Pomalidomide-C7-COOH 98.07% Unkown
HY-149577 EBV lytic cycle inducer-1 Inducer 98.27% Unkown
HY-150746 ODN 24991 Inhibitor ≥96.0% Unkown
HY-131878 Pomalidomide-C7-NH2 hydrochloride 98.98% Unkown
HY-150745 ODN 24987 Inhibitor / Unkown
HY-16676 7-Epi-docetaxel Inhibitor 99.49% Unkown
HY-130640 (S,R,S)-AHPC-Me-C7 ester 95.49% Unkown
HY-148671 (S,R,S)-AHPC-amido-C7-acid 98.28% Unkown
HY-N6802 Tigloylgomisin H / Unkown
HY-130949 Thalidomide-4-O-C7-NH2 / Unkown
HY-131874 Thalidomide-O-C7-acid / Unkown
HY-100807S1 Quinolinic acid-13C7 / Unkown
HY-128746S 2,6-Diaminoheptanedioic acid-13C7,15N2 / Unkown
HY-131740 2'-Deoxytubercidin 5'-triphosphate / Unkown
HY-131740A 2'-Deoxytubercidin 5'-triphosphate sodium / Unkown
HY-136005 VH032-C7-COOH / Unkown
HY-136186 (S,R,S)-AHPC-C7-amine / Unkown
HY-136186B (S,R,S)-AHPC-C7-amine hydrochloride / Unkown
HY-149645 CB2 receptor antagonist 2 / Unkown
HY-151274 SARS-CoV-2-IN-28 Inhibitor / Unkown
HY-151274A SARS-CoV-2-IN-28 disodium Inhibitor / Unkown
HY-151468 AIE-Cbz-LD-C7 / Unkown
HY-155263 Pomalidomide-5-C7-NH2 hydrochloride / Unkown
HY-155527 SARS-CoV-2 Mpro-IN-9 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-B0315S Vitamin B12-13C7 ≥96.0% Unkown
HY-N0294S1 Protocatechuic acid-13C7 / Unkown
HY-N10344 Glucoarabin / Unkown
HY-N6779S Patulin-13C7 / Unkown
HY-N7777 7-Xylosyl-10-Deacetyltaxol C / Unkown
HY-P3801 [Glp5,(Me)Phe8,Sar9] Substance P (5-11) Modulator / Unkown
HY-RS01753 C7 Human Pre-designed siRNA Set A / Unkown
HY-RS01754 C7orf50 Human Pre-designed siRNA Set A / Unkown
HY-RS05971 H3C7 Human Pre-designed siRNA Set A / Unkown
HY-RS12598 SDR9C7 Human Pre-designed siRNA Set A / Unkown
HY-W012340S L-Homoarginine-13C7,15N4 hydrochloride / Unkown
HY-W016087 Monoethyl pimelate / Unkown
HY-W334800S (2S,6S)-2,6-Diaminoheptanedioic acid-13C7,15N2 / Unkown
HY-W334800S2 (2S,6S)-2,6-Diaminoheptanedioic acid-13C7 / Unkown
HY-W753671 2,6-Diaminoheptanedioic acid-13C7 / Unkown
HY-Y1027S 2-Chlorobenzoic Acid-13C7 / Unkown
HY-130949B Thalidomide-4-O-C7-NH2 hydrochloride 99.80% Unkown
HY-136186A (S,R,S)-AHPC-C7-amine dihydrochloride / Unkown
HY-149564 Thalidomide-5-O-C7-NH2 hydrochloride 98.13% Unkown
HY-153541 AP-C7 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus C7 MGD MGI:88235
Felis catus C7 VGNC VGNC:60234
Macaca mulatta C7 VGNC VGNC:70478
Rattus norvegicus C7 RGD RGD:620318
Canis familiaris C7 VGNC VGNC:38599
Bos taurus C7 VGNC VGNC:26643
Macaca fascicularis C7 NCBI
Others C7 NCBI