1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-2-IN-28 disodium

SARS-CoV-2-IN-28 disodium 

Cat. No.: HY-151274A
Handling Instructions

SARS-CoV-2-IN-28 disodium is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 disodium exhibits antiviral activity with IC50s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 disodium induces liposomal membrane disruption with an EC50 value of 4.4 μM.

For research use only. We do not sell to patients.

SARS-CoV-2-IN-28 disodium Chemical Structure

SARS-CoV-2-IN-28 disodium Chemical Structure

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Description

SARS-CoV-2-IN-28 disodium is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 disodium exhibits antiviral activity with IC50s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 disodium induces liposomal membrane disruption with an EC50 value of 4.4 μM[1].

IC50 & Target

IC50: 4.4 μM (viral liposome, SARS-CoV-2)[1]

In Vitro

SARS-CoV-2-IN-28 (CP020) disodium inhibits SARS-CoV-2 (IC50=1.0 μM) with few cytotoxicity (Caco2 cells, CC50=213.1 μM)[1].
SARS-CoV-2-IN-28 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.4 μM[1].
SARS-CoV-2-IN-28 disodium suppresses varies enveloped viruses activity with IC50s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration: 0, 0.23, 0.93, 3.75, 15 μM
Incubation Time: 2 hours; determined infection rates on day 2
Result: Inhibited SARS-CoV-2 infection activity to Caco2 cells.
Molecular Weight

966.98

Formula

C56H58Na2O8P2

SMILES

CCCCCCCOP(OC(C1=C2C3C4=CC(C5CC6C7=C5C=CC=C7)=C6C=C4C1C3)=C(C8C9=C(C%10C8)C=C%11C(C%12C%13=C(C%11C%12)C=CC=C%13)=C9)C%10=C2OP(OCCCCCCC)(O[Na])=O)(O[Na])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Product Name:
SARS-CoV-2-IN-28 disodium
Cat. No.:
HY-151274A
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