SARS-CoV-2-IN-28 disodium
SARS-CoV-2-IN-28 disodium is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 disodium exhibits antiviral activity with IC50s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 disodium induces liposomal membrane disruption with an EC50 value of 4.4 μM.
For research use only. We do not sell to patients.
- Formula: C56H58Na2O8P2
- Molecular Weight:966.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 4.4 μM (viral liposome, SARS-CoV-2)[1]
SARS-CoV-2-IN-28 (CP020) disodium inhibits SARS-CoV-2 (IC50=1.0 μM) with few cytotoxicity (Caco2 cells, CC50=213.1 μM)[1].
SARS-CoV-2-IN-28 disodium (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 0.4 μM[1].
SARS-CoV-2-IN-28 disodium suppresses varies enveloped viruses activity with IC50s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
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Concentration:0, 0.23, 0.93, 3.75, 15 μM
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Incubation Time:2 hours; determined infection rates on day 2
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Result:Inhibited SARS-CoV-2 infection activity to Caco2 cells.
Chemical Information
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Molecular Weight 966.98
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Formula C56H58Na2O8P2
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SMILES
CCCCCCCOP(OC(C1=C2C3C4=CC(C5CC6C7=C5C=CC=C7)=C6C=C4C1C3)=C(C8C9=C(C%10C8)C=C%11C(C%12C%13=C(C%11C%12)C=CC=C%13)=C9)C%10=C2OP(OCCCCCCC)(O[Na])=O)(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SARS-CoV-2-IN-28 disodium Related Classifications
HY-151274A Related Classifications
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