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Cat. No.: HY-151274

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SARS-CoV-2-IN-28

SARS-CoV-2-IN-28 is a two-armed diphosphate ester with C7 alkyl and molecular tweezers with extended length. SARS-CoV-2-IN-28 exhibits antiviral activity with IC₅₀s of 0.4 μM and 1.0 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-28 induces liposomal membrane disruption with an EC₅₀ value of 4.4 μM.

For research use only. We do not sell to patients.

Formula: C₅₆H₆₀O₈P₂
Molecular Weight:923.02

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

SARS-CoV-2-IN-28 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 4.4 μM (viral liposome, SARS-CoV-2)^[1]

In Vitro

SARS-CoV-2-IN-28 (CP020) inhibits SARS-CoV-2 (IC₅₀=1.0 μM) with few cytotoxicity (Caco2 cells, CC₅₀=213.1 μM)^[1].
SARS-CoV-2-IN-28 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC₅₀ value of 0.4 μM^[1].
SARS-CoV-2-IN-28 suppresses varies enveloped viruses activity with IC₅₀s of 7.1 μM (respiratory syncytial virus, RSV), 24.5 μM (influenza A virus, IAV), 4.0 μM (measles virus, MeV), 1.6 μM (herpes simplex viruses, HSV-1), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration:

0, 0.23, 0.93, 3.75, 15 μM
Incubation Time:

2 hours; determined infection rates on day 2
Result:

Inhibited SARS-CoV-2 infection activity to Caco2 cells.

Chemical Information

Molecular Weight 923.02
Formula C₅₆H₆₀O₈P₂
SMILES

OP(OC1=C2C(C3C4=C(C2C3)C=C5C(C6C7=C(C5C6)C=CC=C7)=C4)=C(C8=C1C9C%10=CC(C%11CC%12C%13=C%11C=CC=C%13)=C%12C=C%10C8C9)OP(OCCCCCCC)(O)=O)(OCCCCCCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tatjana Weil, et al. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022, XXXX, XXX, XXX-XXX.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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