10-SLF
10-SLF is a PROTAC FKBP12 degrader. 10-SLF induces a ternary complex between FKBP12 and FBXW7-R465C, and promotes FBXW7-R465C-dependent proteasomal degradation of FKBP12. 10-SLF selectively reduces FKBP12 levels in cells expressing FBXW7-R465C.
(Pink: FKBP12 ligand (HY-170988); Blue: E3 ligase ligand; Black: linker (HY-W004640)).
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- CAS. Nr.: 2765058-89-5
- Formel: C59H76Cl2N4O13
- Molecular Weight:1120.16
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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FKBP12 |
Chemical Information
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CAS. Nr. 2765058-89-5
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Molecular Weight 1120.16
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Formel C59H76Cl2N4O13
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SMILES
O=C([C@H]1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@H](CCC2=CC(OC)=C(C=C2)OC)C3=CC=CC(OCC(NCCCOCCOCCOCCCN(C(CCl)=O)C(C4=CC=C(C=C4)Cl)C(NCC5=CC=CC=C5)=O)=O)=C3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
10-SLF Related Classifications
HY-173082 Related Classifications
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