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Cat. No.: HY-181356

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(S,R,S,R)-AHPC-Me-CO-C7-N3

(S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355).

For research use only. We do not sell to patients.

CAS No.: 2977227-44-2
Formula: C₃₁H₄₅N₇O₄S
Molecular Weight:611.80

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S,R,S,R)-AHPC-Me-CO-C7-N3 Chemical Structure

CAS No.: 2977227-44-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2977227-44-2
Molecular Weight 611.80
Formula C₃₁H₄₅N₇O₄S
SMILES

O=C(N1[C@@H](C[C@H](C1)O)C(N[C@@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCCN=[N+]=[N-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. S Abulkhair H. Therapeutic horizons in the development of PROTAC-based EZH2 inhibitors: recent achievements, comparative analysis, and future perspectives. RSC Adv. 2026 Jan 14;16(4):3034-3056. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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