PROTAC EZH2 Degrader-28
PROTAC EZH2 Degrader-28 is an EZH2 PROTAC degrader. PROTAC EZH2 Degrader-28 promotes the ubiquitination and degradation of EZH2. PROTAC EZH2 Degrader-28 can be used for lymphoma-related research.
(Pink: EZH2 ligand (HY-179351); Blue: VHL ligand (HY-112078A); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3093642-29-3
- Formula: C68H90N12O8S
- Molecular Weight:1235.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PROTAC EZH2 Degrader-28 (compound 66) reduces proliferation of SU-DHL-6 lymphoma cells with an IC50 value of 16.2 μM, and has no measurable antiproliferative activity (IC50 >30 μM) in HBL-1 lymphoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3093642-29-3
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Molecular Weight 1235.58
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Formula C68H90N12O8S
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SMILES
CCN(C1CCOCC1)C2=CC(C3=CC=C(C=C3)CN4CCN(CC4)C(C5=CN(N=N5)CCCCCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@@H](C7=CC=C(C8=C(C)N=CS8)C=C7)C)=O)=O)=O)=O)=CC(C(NCC9=C(C=C(NC9=O)C)C)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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