2977227-44-2
2977227-44-2
Chemical Structure
(S,R,S,R)-AHPC-Me-CO-C7-N3
- CAS No.: 2977227-44-2
- Formula:C31H45N7O4S
- Molecular Weight:611.80
InChIKey: RMAGYBBYAWIFSC-RMQHFTFXSA-N
SMILES: O=C(N1[C@@H](C[C@H](C1)O)C(N[C@@H](C2=CC=C(C3=C(C)N=CS3)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCCCCN=[N+]=[N-])=O
Biological Activity: (S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355)[1].
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(S,R,S,R)-AHPC-Me-CO-C7-N3 | (S,R,S,R)-AHPC-Me-CO-C7-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S,R)-AHPC-Me based VHL ligand and a linker used in PROTAC technology. (S,R,S,R)-AHPC-Me-CO-C7-N3 can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-28 (HY-181355). | |||||||||||||||||||||
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References
Keywords
