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  4. Abciximab

Abciximab  (Synonyms: C7E3)

Cat. No.: HY-P9934 Purity: 99.966%
COA

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Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.

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Abciximab Chemical Structure

Abciximab Chemical Structure

CAS No. : 143653-53-6

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Description

Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors[1].

In Vitro

Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet αIIbβ3 integrin[2].
Abciximab appears to have similar affinity for the αIIbβ3 and αvβ3 integrins and redistributes between them[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Abciximab Related Antibodies
In Vivo

Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200-250 g, balloon angioplasty model[2]
Dosage: 0.25 mg/kg/day
Administration: Intravenous injection, 28 days
Result: Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB2 concentration.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Abciximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.966%

COA (291 KB)

Handling Instructions (2659 KB)
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Abciximab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abciximab143653-53-6C7E3Integringlycoprotein IIb/IIIaplatelet aggregationleucocyte adhesionvitronectinMac-1neointimal hyperplasiaInhibitorinhibitorinhibit

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