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Cat. No.: HY-131740A

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2'-Deoxytubercidin 5'-triphosphate sodium

Name: 2'-Deoxytubercidin 5'-triphosphate sodium
Brand: MedChemExpress
SKU: HY-131740A
Availability: PreOrder

(Synonyms: C7dATP sodium)

2'-Deoxytubercidin 5'-triphosphate sodium (C7dATP sodium) is a deoxyadenosine triphosphate (dATP) analog that serves as a substrate for DNA polymerases. 2'-Deoxytubercidin 5'-triphosphate sodium eliminates Hoogsteen base-pairing capacity and weakens base-stacking interactions; it is recognized and incorporated into nascent DNA strands by DNA polymerases such as Klenow and T7; it reduces DNA electrophoresis compression artifacts; it is effectively degraded by apyrase, thereby lowering the enzyme product inhibition effect caused by dATPaS. 2'-Deoxytubercidin 5'-triphosphate sodium reduces abnormal electrophoretic mobility caused by compression of G or A residues and is used to improve the quality of DNA sequencing data.

For research use only. We do not sell to patients.

Formula: C₁₁H₁₃N₄Na₄O₁₂P₃
Molecular Weight:578.12

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

2'-Deoxytubercidin 5'-triphosphate sodium Chemical Structure

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Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

2'-Deoxytubercidin 5'-triphosphate sodium (C7dATP) exhibits very low substrate activity toward firefly luciferase, with a relative luminescence value of 0.006% (with ATP set as 100%); it exerts only a weak inhibitory effect on apyrase activity, as its intermediate hydrolysis product c7dADP is efficiently degraded by apyrase^[1].
2'-Deoxytubercidin 5'-triphosphate sodium is a fully functional and high-performance alternative to dATPaS, which supports long-read pyrosequencing on various microbial, viral, and plasmid DNA templates^[1].
2'-Deoxytubercidin 5'-triphosphate sodium resolves A-related electrophoretic band compression in radiolabeled chain-termination sequencing of the 4 kbp pRK plasmid insert DNA that cannot be corrected by 7-deaza-dGTP alone^[2].
2'-Deoxytubercidin 5'-triphosphate sodium eliminates band compression associated with A and improves the accuracy of automatic base calling in fluorescence sequencing^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 578.12
Formula C₁₁H₁₃N₄Na₄O₁₂P₃
SMILES

O=P(O[Na])(O[Na])OP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3C=C2)C[C@@H]1O)(O[Na])=O)(O[Na])=O
Synonyms

C7dATP sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jonas Eriksson, et al. 7‑Deaza‑2′‑Deoxyadenosine‑5′‑Triphosphate as an Alternative Nucleotide for the Pyrosequencing Technology. Nucleosides, Nucleotides & Nucleic Acids. 2004;23 (10):1583‑1594.

[2]. Jensen MA, et al. Improvements in the chain-termination method of DNA sequencing through the use of 7-deaza-2'-deoxyadenosine. DNA sequence : the journal of DNA sequencing and mapping. 1991;1(4):233-9. [Content Brief]

[3]. Gourlain T, et al. Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR. Nucleic acids research. 2001 May 01;29(9):1898-905.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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2'-Deoxytubercidin 5'-triphosphate sodium

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2'-Deoxytubercidin 5'-triphosphate sodium

All DNA/RNA Synthesis Isoforms

Biological Activity

Description

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

2'-Deoxytubercidin 5'-triphosphate sodium Related Classifications

HY-131740A Related Classifications

Bioz

Keywords

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