Pomalidomide-C7-NH2 hydrochloride (Synonyms: Pomalidomide 4'-alkylC7-amine hydrochloride)

Cat. No.: HY-131878 Purity: 98.98%: FAQs
Data Sheet SDS COA Handling Instructions

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Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC.

For research use only. We do not sell to patients.

Pomalidomide-C7-NH2 hydrochloride Chemical Structure

CAS No. : 2446474-05-9

Size	Price	Stock	Quantity
5 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 190	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Pomalidomide-C7-NH2 (Pomalidomide 4'-alkylC7-amine) hydrochloride is an E3 ligase ligand-linker conjugate. Pomalidomide-C7-NH2 hydrochloride can be used for the synthesis of PROTAC^[1]^[2].

Molecular Weight

422.91

Formula

C₂₀H₂₇ClN₄O₄

CAS No.

2446474-05-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCCCCCCN)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (295.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3646 mL	11.8228 mL	23.6457 mL
5 mM	0.4729 mL	2.3646 mL	4.7291 mL
10 mM	0.2365 mL	1.1823 mL	2.3646 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.98%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (248 KB) HNMR (272 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]

[2]. Si Woo Choi, et al. Hmg-coa reductase degradation inducing compound. Patent, WO2021201577A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3646 mL	11.8228 mL	23.6457 mL	59.1142 mL
	5 mM	0.4729 mL	2.3646 mL	4.7291 mL	11.8228 mL
	10 mM	0.2365 mL	1.1823 mL	2.3646 mL	5.9114 mL
	15 mM	0.1576 mL	0.7882 mL	1.5764 mL	3.9409 mL
	20 mM	0.1182 mL	0.5911 mL	1.1823 mL	2.9557 mL
	25 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	30 mM	0.0788 mL	0.3941 mL	0.7882 mL	1.9705 mL
	40 mM	0.0591 mL	0.2956 mL	0.5911 mL	1.4779 mL
	50 mM	0.0473 mL	0.2365 mL	0.4729 mL	1.1823 mL
	60 mM	0.0394 mL	0.1970 mL	0.3941 mL	0.9852 mL
	80 mM	0.0296 mL	0.1478 mL	0.2956 mL	0.7389 mL
	100 mM	0.0236 mL	0.1182 mL	0.2365 mL	0.5911 mL

Pomalidomide-C7-NH2 hydrochloride Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-C7-NH22446474-05-9Pomalidomide 4'-alkylC7-amineE3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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Pomalidomide-C7-NH2 hydrochloride (Synonyms: Pomalidomide 4'-alkylC7-amine hydrochloride)

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Complete Stock Solution Preparation Table

Pomalidomide-C7-NH2 hydrochloride Related Classifications

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