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5-Lipoxygenase (5-LOX)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amyloid-β (1) Apoptosis (6) Autophagy (2) Caspase (2) Chemerin Receptor (1) COX (10) Endogenous Metabolite (2) Epoxide Hydrolase (1) Ferroptosis (2) FLAP (4) GABA Receptor (1) Leukotriene Receptor (7) Lipoxygenase (35) MMP (1) NF-κB (2) Opioid Receptor (1) PGE synthase (1) Phospholipase (1) PPAR (1) Reactive Oxygen Species (ROS) (1) Reference Standards (5) Tyrosinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (30) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 5+ Cited Publications NDGA	Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid is a *5-lipoxygenase* (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N0551

Wedelolactone Maximum Cited Publications 24 Publications Verification	Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits *5-lipoxygenase* (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-B1452

Licofelone 1 Publications Verification ML-3000	COX Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Licofelone (ML-3000) is a dual **COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis**, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s?of? 30 and 170?nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20?nM) .

HY-A0060

Malotilate NKK 105	Lipoxygenase	Cancer
Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the **5-lipoxygenase (5-LOX) (IC₅₀**=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Lipoxygenase Leukotriene Receptor NF-κB	Metabolic Disease Cancer
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit **5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB)** activation and tumor necrosis factor alpha generation production .

HY-W009248

Phenethyl ferulate	COX Lipoxygenase	Inflammation/Immunology
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and *5-lipoxygenase* (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively .

HY-W041193

3-Hydroxy-2-pyrone	MMP Lipoxygenase Tyrosinase	Infection Inflammation/Immunology Cancer
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme *5-lipoxygenase* (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation .

HY-133159

Resolvin E2 (-)-Resolvin E2	Endogenous Metabolite Leukotriene Receptor Chemerin Receptor COX Lipoxygenase	Neurological Disease Inflammation/Immunology
Resolvin E2 ((-)-Resolvin E2) is an endogenous lipid mediator produced from eicosapentaenoic acid (EPA) under the catalysis of 5-lipoxygenase (5-LOX), and its production increases in hypoxic environments. Resolvin E2 antagonizes BLT1, partially activates ChemR23, and promotes ubiquitin-proteasome-mediated degradation of COX-2. Resolvin E2 reduces the production of prostaglandin E₂, blocks polymorphonuclear leukocyte infiltration, and promotes the resolution of airway inflammation. Resolvin E2 ameliorates lipopolysaccharide (LPS) (HY-D1056)-induced depressive-like behaviors . Resolvin E2 can be used in research related to depression, murine peritonitis, neonatal asthma, and other conditions .

HY-148134

5-LOX-IN-1	Lipoxygenase	Inflammation/Immunology
5-LOX-IN-1 (compound 2b) is an inhibitor of human 5-Lipoxygenase *(5-LOX)* with an IC₅₀ value of 2.3 μM. 5-LOX-IN-1 can be used for the research of inflammation .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent **5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀** values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-117048

PF-4191834 PF-04191834	Lipoxygenase	Inflammation/Immunology
PF-4191834 (PF-04191834) is an orally active, noniron chelating, and non-redox inhibitor of the **5-Lipoxygenase (5-LOX) (IC₅₀*=229 nM), displays ~300-fold selectivity for 5-LOX* over 12-LOX and 15-LOX, shows no activity toward the cyclooxygenase enzymes, and is effective in inflammation and pain .

HY-U00308

5-LOX-IN-4	Lipoxygenase	Cardiovascular Disease Inflammation/Immunology
5-LOX-IN-4 is a *5-Lipoxygenase* inhibitor extracted from patent EP 331232 A2, table 4, compound example 4.10.

HY-138939

5-LOX-IN-2	Lipoxygenase	Cancer
5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC₅₀ of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research .

HY-111140

YS121	PGE synthase Lipoxygenase PPAR	Inflammation/Immunology
YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC₅₀ = 3.4 μM) and 5-lipoxygenase (5-LOX; IC₅₀ = 6.5 μM). YS121 exhibits direct, reversible, and specific binding to mPGES-1 (K_D = 10-14 μM) . YS121 dose-dependently reduces PGE₂ production with an EC₅₀ of 12 μM in IL-1β-stimulated A549 cells . YS121 (compound 9) activates PPAR-α and -γ (EC₅₀ = 1 and 3.6 μM, respectively) . YS121 exhibits anti-inflammatory efficiency in human whole blood as well as in vivo. YS121 can be used for pleurisy research .

HY-N0198R

Nordihydroguaiaretic acid (Standard) NDGA (Standard)	Reference Standards Lipoxygenase Autophagy Ferroptosis	Neurological Disease Cancer
Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-W028263

6-Hydroxyflavanone	COX Opioid Receptor GABA Receptor Lipoxygenase	Metabolic Disease Inflammation/Immunology
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes .

HY-N0551R

Wedelolactone (Standard)	Reference Standards Caspase Lipoxygenase Apoptosis	Inflammation/Immunology Cancer
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-106835

Flobufen VUFB 16066	COX Lipoxygenase	Inflammation/Immunology
Flobufen (VUFB 16066) is a non-steroidal anti-inflammatory agent and cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) inhibitor agent. Flobufen inhibits alloantigen-driven cellular immune responses and stimulates phagocytosis of peritoneal cells. Flobufen can improve immunopathological disorders and has an inhibitory effect on rheumatoid arthritis .

HY-155407

ALR-6	FLAP	Inflammation/Immunology
ALR-6 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-6 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM and has no significant effect on direct inhibition of 5-LOX .

HY-155409

ALR-38	Lipoxygenase	Inflammation/Immunology
ALR-38 is a 5-lipoxygenase (5-LOX) inhibitor (IC₅₀: 1.1 μM) with anti-inflammatory activity. ALR-38 effectively reduces ROS levels in neutrophils .

HY-158204

CNB-001	Lipoxygenase Amyloid-β Reactive Oxygen Species (ROS) Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology
CNB-001 is a potent and orally active *5-lipoxygenase* (5-LOX) inhibitor. CNB-001 can decreases 5-LOX expression and increase proteasome activity. CNB-001 can inhibit accumulation of soluble Amyloid-β and ubiquitinated aggregated proteins. CNB-001 can inhibit apoptosis, ROS production and stabilize mitochondrial membrane potential. CNB-001 can reduce insulin resistance and increase glucose uptake. CNB-001 also exhibits anti-ischemic, anti-inflammatory effects. CNB-001 can be used for the researches of inflammation, neurological and metabolic disease, such as Alzheimer's disease, stroke and diabetes .

HY-155408

ALR-27	FLAP	Inflammation/Immunology
ALR-27 is an antagonist of the 5-lipoxygenase (5-LOX) activating protein FLAP and has anti-inflammatory activity. ALR-27 potently inhibits 5-LOX product formation (>80%) in pro-inflammatory M1-MDM, with no significant direct inhibition of 5-LOX. ALR-27 not only reduces prostaglandin and leukotriene (LT) production in neutrophils but also increases the production of specialized prolytic mediators in specific human macrophage phenotypes .

HY-P10458

5-Lipoxygenase blocking peptide Human/rat 5-LO (130-149)	Lipoxygenase	Others
5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX), which can be utilized to prepare an antibody against 5-LOX .

HY-B1452R

Licofelone (Standard) ML-3000 (Standard)	COX Lipoxygenase Apoptosis Reference Standards	Inflammation/Immunology Cancer
Licofelone (Standard) is the analytical standard of Licofelone. This product is intended for research and analytical applications. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-125770

5(S)-HPETE 1 Publications Verification	Endogenous Metabolite	Inflammation/Immunology
5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis .

HY-173056

Ruthenoleuton	Lipoxygenase	Inflammation/Immunology
Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC₅₀ of 3.49 μM and a K_i of 0.80 μM. Ruthenoleuton has antioxidant activity and can be used in the research of inflammatory diseases .

HY-118268

RG 6866	Lipoxygenase	Cardiovascular Disease
RG 6866 is a 5-lipoxygenase (5-LOX) inhibitor with the potential to inhibit coronary artery constriction and negative cardiac inotropic effects in cardiac inflammatory states. When the heart is stimulated by antigens, RG 6866 can block the antigen-induced reduction in coronary flow in the heart.

HY-172790

Cbz-(S,S)-Pro-Pro-allyl	COX Lipoxygenase	Inflammation/Immunology
Cbz-(S,S)-Pro-Pro-allyl (compound 1a) is a dual inhibitor of cyclooxygenase-2 and *5-lipoxygenase* with IC₅₀ values of 0.146 nM, 0.003 nM, 0.64 nM for COX-1, COX-2, 5-LOX, respectively. Cbz-(S,S)-Pro-Pro-allyl has anti-inflammatory activity .

HY-118848

A63162	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease .

HY-A0060R

Malotilate (Standard) NKK 105 (Standard)	Lipoxygenase Reference Standards	Cancer
Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM). Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes .

HY-114873

LY256548 LY25684	Phospholipase COX Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 (HY-N6687)-stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model .

HY-125975

1-Naphthyl 3,5-dinitrobenzoate	Lipoxygenase	Inflammation/Immunology
1-Naphthyl 3,5-dinitrobenzoate is a potent *5-lipoxygenase* inhibitor with IC₅₀ values of 1.04 µM and 3.6 µM for 5-LOX and mPGES-1, respectively. 1-Naphthyl 3,5-dinitrobenzoate has strong inhibition activity in the human whole blood (HWB) assay with an IC₅₀ value of 8.6 μM. 1-Naphthyl 3,5-dinitrobenzoate can be used in research of inflammation .

HY-N2056R

11-Keto-beta-boswellic acid (Standard) 11-Keto-β-boswellic acid (Standard)	Reference Standards Lipoxygenase Leukotriene Receptor NF-κB	Metabolic Disease Cancer
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-153279

5-LOX-IN-3	Lipoxygenase	Neurological Disease Inflammation/Immunology Cancer
5-LOX-IN-3 (Compound 14) is a *5-Lipoxygenase* inhibitor (IC₅₀: <1 μM). 5-LOX-IN-3 can be used for research of inflammatory diseases, cancer, stroke and Alzheimer's disease .

HY-120502

5-LOX-IN-6	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
5-LOX-IN-6 (compound 11a) is a direct and reversible inhibitor of **5-lipoxygenase (5-LO)*. 5-LOX-IN-6 inhibits 5-LO activity in human neutrophils and recombinant human 5-LO with IC₅₀* values of 0.23 and 0.086 µM, respectively. 5-LOX-IN-6 prevents leukotriene biosynthesis. 5-LOX-IN-6 can be used for inflammatory and allergic disorders research .

HY-B1452S1

Licofelone-d6 ML-3000-d₆	Apoptosis Lipoxygenase COX	Cancer
Licofelone-d₆ is the deuterium labeled Licofelone . Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .

HY-N18235

(1Z)-Atractylodinol	Lipoxygenase	Inflammation/Immunology
(1Z)-Atractylodinol, an acetylenes compound, is a weak **5-lipoxygenase (5-LOX) inhibitor with an IC₅₀** of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases .

HY-118506

BRP-7	FLAP	Inflammation/Immunology
BRP-7 is a 5-lipoxygenase activating protein (FLAP) inhibitor with an IC₅₀ of 0.31 μM. BRP-7 inhibits the co-localization of 5-lipoxygenase (5-LOX) and FLAP by targeting FLAP, thereby blocking the transfer of arachidonic acid (AA) to 5-LOX and suppressing the production of leukotrienes (LTs) (IC₅₀ = 0.15 μM). BRP-7 does not inhibit cyclooxygenase (COX-1/COX-2) or microsomal prostaglandin E₂ synthase-1 (mPGES-1), and does not affect cell viability or AA release. BRP-7 exhibits significant anti-inflammatory effects in rat pleurisy and mouse peritonitis models. BRP-7 can be used for the study of inflammatory diseases .

HY-180363

E 6080	Lipoxygenase Leukotriene Receptor	Inflammation/Immunology
E 6080 is an orally active and selective **5-lipoxygenase (5-LOX) inhibitor with an IC₅₀** of 0.2 μM in rat basophilic leukemia cell. E 6080 shows potent inhibitory effects on the release of leukotrienes. E 6080 inhibits the bronchospasm induced by antigen (ovalbumin) inhalation in sensitized conscious guinea pigs. E 6080 can be used for the study of asthma .

Cat. No.	Product Name	Target	Research Area

HY-P10458

5-Lipoxygenase blocking peptide Human/rat 5-LO (130-149)	Lipoxygenase	Others
5-Lipoxygenase blocking peptide (Human/rat 5-LO 130-149) is a specific sequence fragment of 5-lipoxygenase (5-LOX), which can be utilized to prepare an antibody against 5-LOX .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0198

Nordihydroguaiaretic acid 5+ Cited Publications NDGA	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Lignans Plants other families Phenols Polyphenols Phenylpropanoids Disease Research Fields Source Classification Cancer	Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid is a *5-lipoxygenase* (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-N0551

Wedelolactone Maximum Cited Publications 24 Publications Verification	Classification of Application Fields Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields	Caspase Lipoxygenase Apoptosis
Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits *5-lipoxygenase* (5-Lox) with an IC₅₀ of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-N2056

11-Keto-beta-boswellic acid 11-Keto-β-boswellic acid	Triterpenes Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Source Classification Cancer	Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit **5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB)** activation and tumor necrosis factor alpha generation production .

HY-W009248

Phenethyl ferulate	Monophenols Classification of Application Fields Phenols Plants Umbelliferae Kleinia odora (Forssk.) DC. Disease Research Fields Inflammation/Immunology Source Classification	COX Lipoxygenase
Phenethyl ferulate is a major constituent ofQianghuo, shows inhibitory activity against cyclooxygenase (COX) and *5-lipoxygenase* (5-LOX) with IC₅₀ values of 4.35 μM and 5.75 μM, respectively .

HY-W041193

3-Hydroxy-2-pyrone	Structural Classification Natural Products Actinidia chinensis Planch. Plants Actinidiaceae Source Classification	MMP Lipoxygenase Tyrosinase
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme *5-lipoxygenase* (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation .

HY-N0198R

Nordihydroguaiaretic acid (Standard) NDGA (Standard)	Structural Classification other families Lignans Phenols Polyphenols Phenylpropanoids Plants Source Classification	Reference Standards Lipoxygenase Autophagy Ferroptosis
Nordihydroguaiaretic acid (Standard) is the analytical standard of Nordihydroguaiaretic acid. This product is intended for research and analytical applications. Nordihydroguaiaretic acid is a 5-lipoxygenase (5LOX) (IC₅₀=8 μM) and tyrosine kinase inhibitor.

HY-W028263

6-Hydroxyflavanone	Flavonoids Flavonones Muntingia calabura L. Plants Muntingiaceae Source Classification	COX Opioid Receptor GABA Receptor Lipoxygenase
6-Hydroxyflavanone is a compound that can be isolated from the Muntingia calabura leaves. 6-Hydroxyflavanone targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and opioid and GABA-A receptors that has anti-inflammatory and anti-neuropathic pain potential. 6-Hydroxyflavanone can be used for the research of diabetes .

HY-N0551R

Wedelolactone (Standard)	Structural Classification Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae	Reference Standards Caspase Lipoxygenase Apoptosis
Wedelolactone (Standard) is the analytical standard of Wedelolactone. This product is intended for research and analytical applications. Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .

HY-125770

5(S)-HPETE 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
5(S)-HPETE is a 5-lipoxygenase substrate and Arachidonic acid (HY-109590) metabolite. 5(S)-HPETE forms via 5-LOX-catalyzed hydroperoxidation of arachidonic acid. 5(S)-HPETE undergoes 5-LOX-catalyzed epoxidation (dehydration) to form leukotriene A4. 5(S)-HPETE can be used for the research of asthma, rheumatoid arthritis .

HY-N2056R

11-Keto-beta-boswellic acid (Standard) 11-Keto-β-boswellic acid (Standard)	Triterpenes Structural Classification Terpenoids Boswellia serrata Plants Burseraceae Source Classification	Reference Standards Lipoxygenase Leukotriene Receptor NF-κB
11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production .

HY-N18235

(1Z)-Atractylodinol	Structural Classification Natural Products Plants Compositae Source Classification Erythrina sigmoidea Hua	Lipoxygenase
(1Z)-Atractylodinol, an acetylenes compound, is a weak **5-lipoxygenase (5-LOX) inhibitor with an IC₅₀** of 17.8 μM. (1Z)-Atractylodinol can be used for the study of inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-B1452S1

Licofelone-d6
Licofelone-d₆ is the deuterium labeled Licofelone . Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC₅₀=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82192

	5 Lipoxygenase Antibody (YA1937) 5-LO; 5-LOX; 5LPG; LOG5; MGC163204	WB, IHC-F, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	5 Lipoxygenase Antibody (YA1937) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to 5 Lipoxygenase.

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5-Lipoxygenase (5-LOX)

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