CCl4

By Targets:	Amyloid-β (1) Apoptosis (1) CCR (1) ERK (1) Isotope-Labeled Compounds (1) MAGL (1) Necroptosis (1) NOD-like Receptor (NLR) (1) PGE synthase (1) Phosphodiesterase (PDE) (1) Small Interfering RNA (siRNA) (3) TrxR (1) VEGFR (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (1) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS02102

CCL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4 Human Pre-designed siRNA Set A CCL4 Human Pre-designed siRNA Set A

HY-RS02103

CCL4L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L1 Human Pre-designed siRNA Set A CCL4L1 Human Pre-designed siRNA Set A

HY-RS02104

CCL4L2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CCL4L2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCL4L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CCL4L2 Human Pre-designed siRNA Set A CCL4L2 Human Pre-designed siRNA Set A

HY-N9173

Cupressuflavone	Others	Inflammation/Immunology
Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl₄-induced hepato- and nephrotoxicity in mice .

HY-163092

LEI-515	MAGL Necroptosis	Inflammation/Immunology
LEI-515 is a first-in-class peripherally restricted, reversible MAGL inhibitor. LEI-515 increases 2-AG levels in peripheral organs, but not mouse brain. LEI-515 attenuated liver necrosis, oxidative stress and inflammation in a CCl4-induced acute liver injury model .

HY-121944

Ricinine

Others Others

Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

Ricinine	Others	Others
Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-122951

Eburicoic acid	Others	Cardiovascular Disease
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms . And Eburicoic acid has antidiabetic and antihyperlipidemic effects .

HY-N2998

Ganoderenic acid A	Others	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-121944S

Ricinine-d3

Isotope-Labeled Compounds Others

Ricinine-d₃ is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage[1].
HY-N2358

Blumeatin

Others Inflammation/Immunology

Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

Ricinine-d3	Isotope-Labeled Compounds	Others
Ricinine-d₃ is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage[1].

Blumeatin	Others	Inflammation/Immunology
Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

HY-N3315

Massonianoside B	Others	Inflammation/Immunology
Massonianoside B is an antioxidant, which can be isolated from Cedrus deodara pine needle. Massonianoside B exhibits radicals scavenging capacities, and restores CCL4-impaired activity of antioxidant enzymes .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Others	Inflammation/Immunology
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-133019

ATX inhibitor 5	Phosphodiesterase (PDE)	Inflammation/Immunology
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC₅₀ of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently .

HY-N2109

Macranthoidin A	Others	Metabolic Disease
Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-146350

TrxR-IN-4	TrxR	Cancer
TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level .

HY-121271

Kadsurin	Others	Inflammation/Immunology
Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL₄- induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Others	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

HY-N12016

Fulvotomentoside B	Others	Metabolic Disease
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-145801

XT2	Others	Inflammation/Immunology
XT2 is a potent, orally active, and selective inhibitor of NF-κB-inducing kinase (NIK) with an IC₅₀ of 9.1 nM. XT2 suppresses CCl4-induced upregulation of ALT, a key biomarker of acute liver injury. XT2 also decreases immune cell infiltration into the injured liver tissue. XT2 has the potential for the research of liver inflammatory diseases . XT2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-B0498

Bindarit Maximum Cited Publications 13 Publications Verification AF2838	CCR	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

HY-152293

EVT801	VEGFR ERK	Cancer
EVT801 is an orally active and selective inhibitor of VEGFR-3 (IC₅₀=11 nM), which has antitumor effects. EVT801 inhibits not only VEGF-C-induced human endothelial cell proliferation, but also tumor (lymphatic) angiogenesis in tumor mouse models. EVT801 can reduce tumor hypoxia, immunosuppressive cytokines (CCL4, CCL5) and myeloid derived suppressor cells (MDSC) production. EVT801 has synergistic effect with immune checkpoint therapy (ICT), which improves ICT response rate and has better inhibitory effect on cancer mouse models . EVT801 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-149202

UT-11	PGE synthase	Inflammation/Immunology
UT-11 is a potent and brain-permeable microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor with IC₅₀s of 0.10 μM and 2.00 μM for inhibiting PGE₂ production in human (SK-N-AS) and murine (BV2) cells, respectively .

HY-N0373

Licochalcone B 4 Publications Verification	Amyloid-β Apoptosis NOD-like Receptor (NLR)	Neurological Disease
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction ^[4].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122951

Eburicoic acid	Cardiovascular Disease Triterpenes other families Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields	Others
Eburicoic acid protects the liver from CCl4-induced hepatic damage via antioxidant and anti-inflammatory mechanisms . And Eburicoic acid has antidiabetic and antihyperlipidemic effects .

HY-N2998

Ganoderenic acid A	Triterpenes Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields	Others
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of β-glucuronidase. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N2358

Blumeatin	Flavonoids Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Acacia confusa Merr. Compositae Disease Research Fields Inflammation/Immunology	Others
Blumeatin, isolated from Blumea balsamifera DC, could protect liver against injury induced by CCl4 and thioacetamide (TAA) .

HY-N9173

Cupressuflavone	Structural Classification Flavonols Flavonoids Ginkgoaceae Source classification Plants Ginkgo biloba	Others
Cupressuflavone is a natural product that can be found in Cupressus macrocarpa. Cupressuflavone exhibits anti-inflammatory and antiulcerogenic activities. Cupressuflavone also show protective effects against CCl₄-induced hepato- and nephrotoxicity in mice .

HY-121944

Ricinine	Alkaloids Classification of Application Fields Ricinus communis L. Source classification Other Diseases Pyridine Alkaloids Euphorbiaceae Plants Disease Research Fields	Others
Ricinine exhibits hepatoprotection in CCl4 -induced liver damage .

HY-N3315

Massonianoside B	Structural Classification Cedrus deodara (Roxburgh) G. Don Monophenols Pinaceae Source classification Phenols Plants	Others
Massonianoside B is an antioxidant, which can be isolated from Cedrus deodara pine needle. Massonianoside B exhibits radicals scavenging capacities, and restores CCL4-impaired activity of antioxidant enzymes .

HY-N0823

Lithospermic acid (+)-Lithospermic acid	Classification of Application Fields Labiatae Source classification Samanea saman (Jacq.) Merr. Other Phenylpropanoids Phenols Polyphenols Phenylpropanoids Plants Inflammation/Immunology Disease Research Fields	Others
Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl₄)-induced acute liver damage in vitro and in vivo .

HY-N2109

Macranthoidin A	Triterpenes Structural Classification Caprifoliaceae Classification of Application Fields Terpenoids Source classification Metabolic Disease Plants Disease Research Fields	Others
Macranthoidin A is an orally active saponin from Flos Lonicerae. Macranthoidin A possess protection effects on hepatic injury caused by Acetaminophen, Cd, and CCl4, and conspicuous depressant effects on swelling of ear croton oil .

HY-121271

Kadsurin	Classification of Application Fields Source classification Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill.	Others
Kadsurin, a natural compound from the stems of Kadsura heteroclita (Schizandraceae), results in significant decreases of CCL₄- induced lipid-peroxidation products, such as thiobarbituric acid reactive substances (TBA-RS), conjugated dienes and fluorescent products in the liver of mice .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Classification of Application Fields Typhaceae Source classification Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields	Others
Isorhamnetin 3-O-galactoside (Cacticin), a flavonoid glycoside isolated from Artemisia capillaris Thunberg, which ameliorates CCl4-induced hepatic damage by enhancing the anti-oxidative defense system and reducing the inflammatory signaling pathways. Isorhamnetin 3-O-galactoside (Cacticin) has antithrombotic and anti-inflammatory activities .

HY-N12016

Fulvotomentoside B	Triterpenes Structural Classification Caprifoliaceae Terpenoids Source classification Plants Lonicera macrantha (D. Don) Spreng. Saccharides Monosaccharides	Others
Fulvotomentoside B is a saponin isolated from Lactobacillus flavus. Fulvotomentoside compounds can significantly reduce serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) levels in mice poisoned by CCl₄, d-galactosamine (d-gal) and acetaminophen, and significantly alleviate liver pathology. damage .

HY-B0498

Bindarit Maximum Cited Publications 13 Publications Verification AF2838	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Umbelliferae Disease Research Fields Endocrinology Echinacea angustifolia DC. Cancer	CCR
Bindarit (AF2838) is a selective inhibitor of the monocyte chemotactic proteins *MCP-1/CCL2, MCP-3/CCL7, and MCP-2/CCL8, and no effect on other CC and CXC chemokines such as MIP-1α/CCL3, MIP-1β/CCL4, MIP-3/CCL*23. Bindarit also has anti-inflammatory activity .

HY-N0373

Licochalcone B 4 Publications Verification	Chalcones Flavonoids Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch.	Amyloid-β Apoptosis NOD-like Receptor (NLR)
Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (₄₂) self-aggregation (IC₅₀=2.16 μM) and disaggregate pre-formed Aβ₄₂ fibrils, reduce metal-induced Aβ₄₂ aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction ^[4].

Species:	Human (2) Mouse (2) Rat (1)
Tag:	His (2) Tag Free (3)
Source:	P. pastoris (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P700165AF

	*Animal-Free CCL4* Protein, Mouse (His)** CCl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4	Mouse	E. coli
	CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers. Animal-Free CCL4 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeCCL4 protein, expressed by E. coli, with N-His labeled tag. The total length of Animal-Free CCL4 Protein, Mouse (His) is 69 a.a., with molecular weight of ~8.64 kDa.

HY-P71899

	CCL4 Protein, Rat CCl4; Mip1b; Scya4C-C motif chemokine 4; Macrophage inflammatory protein 1-beta; MIP-1-beta; Small-inducible cytokine A4	Rat	E. coli
	CCL4 protein, a monokine, acts as a homodimer and displays inflammatory and chemokinetic properties. CCL4 Protein, Rat is the recombinant rat-derived CCL4 protein, expressed by E. coli , with tag free. The total length of CCL4 Protein, Rat is 69 a.a., with molecular weight of ~11 kDa.

HY-P7257

	CCL4 Protein, Human rHuMIP-1β/CCl4; C-C motif chemokine 4; LAG-1; Macrophage inflammatory protein 1-beta; SCYA4	Human	E. coli
	CCL4 Protein, Human is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human is a recombinant human CCL4 (A24-N92) expressed by E. coli.

HY-P71889

	CCL4 Protein, Mouse CCl4; Mip1b; Scya4; C-C motif chemokine 4; Immune activation protein 2; ACT-2; ACT2; Macrophage inflammatory protein 1-beta; MIP-1-beta; Protein H400; SIS-gamma; Small-inducible cytokine A4	Mouse	E. coli
	CCL4 protein, with inflammatory and chemokinetic properties, acts as a monokine and self-associates to form homodimers. CCL4 Protein, Mouse is the recombinant mouse-derived CCL4 protein, expressed by E. coli , with tag free. The total length of CCL4 Protein, Mouse is 69 a.a., with molecular weight of ~7.8 kDa.

HY-P74342

	CCL4 Protein, Human (P.pastoris, His) MIP-1β/CCl4; C-C motif chemokine 4; LAG-1; SCYA4	Human	P. pastoris
	CCL4 Protein, Human (P.pastoris, His) is a small cytokine of the CC chemokine subfamily that binds to the CCR5 chemokine receptor on the cell surface, promotes leukocyte aggregation under various inflammatory conditions, and contributes to immune protection against human immunodeficiency virus type 1. CCL4 Protein, Human (P.pastoris, His) is a recombinant human CCL4 (A24-Q92) expressed by P. pastoris with a His tag at the C-terminu.


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Cat. No.	Product Name	Chemical Structure

HY-121944S

Ricinine-d3

Ricinine-d₃ is the deuterium labeled Ricinine. Ricinine exhibits hepatoprotection in CCl4 -induced liver damage[1].

Cat. No.	Product Name	Application	Reactivity

HY-P82814

CCL4 beta Antibody (YA2559)

ACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta
WB, ICC/IF, IP Human, Mouse

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