1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. ATX inhibitor 5

ATX inhibitor 5 

Cat. No.: HY-133019
Handling Instructions

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 has anti-hepatofibrosis effect, and reduces CCl4-induced hepatic fibrosis level prominently.

For research use only. We do not sell to patients.

ATX inhibitor 5 Chemical Structure

ATX inhibitor 5 Chemical Structure

CAS No. : 2402772-45-4

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Description

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 has anti-hepatofibrosis effect, and reduces CCl4-induced hepatic fibrosis level prominently[1].

IC50 & Target[1]

Autotaxin

 

In Vitro

ATX inhibitor 5 displays anti-proliferative activities with IC50s of 1.21 and 0.78 µM, respectively[1].

Cell Proliferation Assay[1]

Cell Line: CFs and t-HSC/Cl-6 cells
Concentration: 0.0001, 0.01, 1, 100, 10000 µM
Incubation Time: 48 hours
Result: Displayed activities against CFs and t-HSC/Cl-6 cells with IC50s of 1.21 and 0.78 µM, respectively.
In Vivo

ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently[1].

Animal Model: Male Konmin mice (8-week old, 22-25 g)[1]
Dosage: 20, 40 mg/kg
Administration: Orally; once daily for two weeks
Result: Prominently reduced CCl4-induced hepatic fibrosis level.
Molecular Weight

474.87

Formula

C₂₂H₁₈ClF₃N₆O

CAS No.

2402772-45-4

SMILES

O=C(N/N=C/C1=CC=C(Cl)C=C1)N(C2)CCC3=C2C(NC4=CC=CC(C(F)(F)F)=C4)=NC=N3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ATX inhibitor 5ATX inhibitor5ATX inhibitor-5Phosphodiesterase (PDE)fibrosisdiseasescardiacfibroblastsCFshepaticstellatecellHSCanti-hepatofibrosisanti-proliferative,Inhibitorinhibitorinhibit

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ATX inhibitor 5
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HY-133019
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