1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. ATX inhibitor 5

ATX inhibitor 5 

Cat. No.: HY-133019 Purity: 99.77%
Handling Instructions

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently.

For research use only. We do not sell to patients.

ATX inhibitor 5 Chemical Structure

ATX inhibitor 5 Chemical Structure

CAS No. : 2402772-45-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 366 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 366 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].

IC50 & Target[1]

Autotaxin

 

In Vitro

ATX inhibitor 5 (compound 10g) (IC50s=1.21 and 0.78 μM) displays activities against cardiac fibroblasts (CFs) and hepatic stellate cell (HSC)[1].
ATX inhibitor 5 at 10 μM successfully suppresses collagen content induced by TGF-β[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: CFs and t-HSC/Cl-6 cells
Concentration: 0.0001, 0.01, 1, 100, 10000 µM
Incubation Time: 48 hours
Result: Displayed activities against CFs and t-HSC/Cl-6 cells with IC50s of 1.21 and 0.78 µM, respectively.
In Vivo

ATX inhibitor 5 (20-40 mg/kg; p.o.; once daily for two weeks) reduces CCl4-induced hepatic fibrosis level prominently[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Konmin mice (8-week old, 22-25 g)[1]
Dosage: 20, 40 mg/kg
Administration: Orally; once daily for two weeks
Result: Prominently reduced CCl4-induced hepatic fibrosis level.
Molecular Weight

474.87

Formula

C₂₂H₁₈ClF₃N₆O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (526.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1058 mL 10.5292 mL 21.0584 mL
5 mM 0.4212 mL 2.1058 mL 4.2117 mL
10 mM 0.2106 mL 1.0529 mL 2.1058 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.38 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ATX inhibitor 5
Cat. No.:
HY-133019
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