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Results for "

CID

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin-converting Enzyme (ACE) (1) Antibiotic (1) Apoptosis (5) Bacterial (3) Bcl-2 Family (2) BCRP (1) Biochemical Assay Reagents (2) CD38 (1) CDK (2) DNA/RNA Synthesis (2) DYRK (1) Endogenous Metabolite (1) Fluorescent Dye (3) Fungal (2) GPR35 (3) GPR55 (7) HCV (1) HCV Protease (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) Isotope-Labeled Compounds (1) KLF (1) mAChR (2) Microtubule/Tubulin (1) Neurokinin Receptor (3) NF-κB (1) NOD-like Receptor (NLR) (1) Orphan GPCR (1) Phosphatase (1) Phospholipase (3) PKD (4) Potassium Channel (2) Prostaglandin Receptor (1) Ras (6) Reference Standards (4) ROR (1) SARS-CoV (1) Virus Protease (2)
By Research Areas:	Cancer (24) Cardiovascular Disease (5) Endocrinology (4) Infection (9) Inflammation/Immunology (12) Metabolic Disease (6) Neurological Disease (14)

By Targets:

Angiotensin-converting Enzyme (ACE) (1)

Antibiotic (1)

Apoptosis (5)

Bacterial (3)

Bcl-2 Family (2)

BCRP (1)

Biochemical Assay Reagents (2)

CD38 (1)

CDK (2)

DNA/RNA Synthesis (2)

DYRK (1)

Endogenous Metabolite (1)

Fluorescent Dye (3)

Fungal (2)

GPR35 (3)

GPR55 (7)

HCV (1)

HCV Protease (1)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (1)

Isotope-Labeled Compounds (1)

KLF (1)

mAChR (2)

Microtubule/Tubulin (1)

Neurokinin Receptor (3)

NF-κB (1)

NOD-like Receptor (NLR) (1)

Orphan GPCR (1)

Phosphatase (1)

Phospholipase (3)

PKD (4)

Potassium Channel (2)

Prostaglandin Receptor (1)

Ras (6)

Reference Standards (4)

ROR (1)

SARS-CoV (1)

Virus Protease (2)

By Research Areas:

Cancer (24)

Cardiovascular Disease (5)

Endocrinology (4)

Infection (9)

Inflammation/Immunology (12)

Metabolic Disease (6)

Neurological Disease (14)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12755

ML141 Maximum Cited Publications 32 Publications Verification CID-2950007	Ras Apoptosis	Cancer
ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC₅₀s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines .

HY-16346

Netupitant 4 Publications Verification CID 6451149	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

HY-13452

CID-1067700 10+ Cited Publications ML282	Ras	Inflammation/Immunology
CID-1067700 (ML282) is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a K_i of 13 nM.

HY-18639

Nodinitib-1 10+ Cited Publications ML130; CID-1088438	NOD-like Receptor (NLR)	Inflammation/Immunology
Nodinitib-1 (ML130;CID-1088438) is a NOD1 inhibitor with an IC₅₀ of 0.56 μM.

HY-12342

ML216 5+ Cited Publications CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 μM. Antitumor avtivity .

HY-107537

CID 2745687	GPR35	Cardiovascular Disease Inflammation/Immunology
CID 2745687 acts as a specific, reversible and competitive GPR35 antagonist with a K_i of 12.8 nM .

HY-19800

ML-098 10+ Cited Publications CID-7345532	Ras	Cancer
ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 with an EC₅₀ of 77.6 nM.

HY-12754

ML228 5+ Cited Publications CID-46742353	HIF/HIF Prolyl-Hydroxylase	Cancer
ML228 (CID-46742353) is a potent the Hypoxia Inducible Factor (HIF) pathway activator with EC₅₀ of 1 μM. ML228 potently activates HIF in vitro as well as its downstream target VEGF .

HY-12343

ML277 1 Publications Verification CID-53347902	Potassium Channel	Cardiovascular Disease
ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC₅₀=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes .

HY-110125

ML-193 1 Publications Verification CID 1261822	GPR55	Neurological Disease
ML-193 (CID 1261822) is a potent and selective antagonist of GPR55, with an IC₅₀ of 221 nM. ML-193 shows more than 27-fold selectivity for GPR55 over GPR35, CB1 and CB2. ML-193 can improve the motor and the sensorimotor deficits of Parkinson’s disease (PD) rats .

HY-16697

CID 16020046 2 Publications Verification	GPR55	Cancer
CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC₅₀ of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca ²⁺ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function .

HY-123740

Disuccinimidyl sulfoxide DSSO	Biochemical Assay Reagents	Others
Disuccinimidyl sulfoxide (DSSO) is a sulfoxide-containing crosslinker targeting amino groups that can be cleaved by MS, and it is suitable for model peptides, proteins, and multisubunit protein complexes. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites, enabling the identification of DSSO-crosslinked peptides based on different fragmentation patterns .

HY-13454

CID 2011756	PKD	Cancer
CID 2011756 is an ATP competitive PKD inhibitor, with an IC₅₀ of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC₅₀, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

HY-124306

ML-099 5 Publications Verification CID-888706	Ras	Cancer
ML-099 (CID-888706) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A .

HY-12239

CID755673 5+ Cited Publications	PKD	Cancer
CID755673 is a potent PKD inhibitor with IC₅₀s of 182 nM, 280 nM and 227 nM for PKD1, PKD2 and PKD3, respectively.

HY-19752A

VU0357017 hydrochloride CID-25010775	mAChR	Neurological Disease
VU0357017 hydrochloride (CID-25010775) is a potent, selective and brain-penetrant allosteric agonist of M₁ muscarinic acetylcholine receptor, with an EC₅₀ of 477 nM. VU0357017 hydrochloride is highly selective for M₁ and has no activity at M₂-M₅ up to the highest concentrations tested (30 μM). VU0357017 hydrochloride can be used for the research of Alzheimer’s disease and schizophrenia .

HY-136379

CID44216842 2 Publications Verification Cdc42-IN-1	Ras	Cancer
CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC₅₀s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe .

HY-110192

ML 297 1 Publications Verification VU 0456810; CID 56642816	Potassium Channel	Neurological Disease
ML 297 (VU 0456810) is a potent and selective GIRK_1/2 activator, with an EC₅₀ of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy .

HY-15951

ML167 CID44968231; NCGC00188654	CDK DYRK	Cancer
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC₅₀ of 136 nM, >10-fold selectivity for closely related kinases Clk1, Clk2, Clk3 and Dyrk1A/1B .

HY-15530

CID-2858522	NF-κB	Inflammation/Immunology Cancer
CID-2858522 is a highly potent and selective antigen receptor-mediated NF-κB activation inhibitor with an IC₅₀ of 70 nM.

HY-114146

CID 1375606	Orphan GPCR	Neurological Disease Metabolic Disease
CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27.

HY-116461

ML-184 CID2440433	GPR55	Neurological Disease
ML-184 (CID244033) is a selective GPR55 agonist with an EC₅₀ of 250 nM, more than 100-fold selectivity for GPR55 over GPR35, CB1, and CB2. ML-184 induces ERK1/2 phosphorylation and PKCβII translocation to the plasma membrane via activation of GPR55. ML-184 (CID2440433) increases the proliferation of neural stem cells and promotes neuronal differentiation in vitro .

HY-101293

VU0359595 1 Publications Verification CID-53361951; ML-270	Phospholipase Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC₅₀ of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC₅₀ of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases .

HY-111083

ML191 CID23612552	GPR55	Others
ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC₅₀=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC₅₀=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM .

HY-W011044

CID 5951923 1 Publications Verification	KLF	Cancer
CID 5951923 is a potent inhibitor of Krüppel-like factor 5 (KLF5), with an IC₅₀ of 603 nM. CID 5951923 can inhibit proliferation of cancer cells in vitro .

HY-100502

CID5721353 1 Publications Verification	Bcl-2 Family Apoptosis	Cancer
CID5721353 is an inhibitor of BCL6 with an IC₅₀ value of 212 μM, which corresponds to a K_i of 147 μM.

HY-111952

SR-4995 CID 16016685	Endogenous Metabolite	Others
SR-4995 (CID 16016685) is a highly effective and selective ligand for α-β-hydrolase domain-containing 5 (ABHD5), facilitating the activation of adipose triglyceride lipase (ATGL) by displacing ABHD5 from its inhibitory regulators, perilipin-1 (PLIN1) and PLIN5. It directly interacts with ABHD5, inhibiting its association with PLIN1, and promotes lipolysis in adipocytes and muscle tissues while circumventing PKA-dependent signaling pathways.

HY-N3125

Osajin CID 95168; NSC 21565	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities.

HY-153129

EP2 receptor antagonist-2	Prostaglandin Receptor	Endocrinology
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA) .

HY-151221

CID 697851	Bacterial	Infection
CID 697851 is an AddAB and RecBCD inhibitor, with IC₅₀s of 13 and 33 nM. CID 697851 can be used for antibacterial research .

HY-118208

ML-097 2 Publications Verification CID-2160985	Ras	Cancer
ML-097 (CID-2160985) is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7 .

HY-160870

Firefly luciferase-IN-3	Fluorescent Dye	Others
Firefly luciferase-IN-3 (CID: 17087944) is an inhibitor of ATP-dependent luciferase (Firefly luciferase) and has nM-level inhibitory activity against NanoLuc (pIC₅₀=7.5) .

HY-120937

DC4 Crosslinker	Biochemical Assay Reagents	Others
DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .

HY-134801

CID1231538	GPR35	Metabolic Disease Inflammation/Immunology
CID1231538, a benzothiazole analog, is a potent GPR35 antagonist with no significant activity against rodent orthologs of GPR35, which is also a G protein-coupled receptor (GPCR) .

HY-16346S

Netupitant-d6 CID-6451149-d₆	Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-111678

ML230 CID44640177; SID 88095709	BCRP	Cancer
ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2, and 36-fold selective for ABCG2 over ABCB1 with EC₅₀s values of 0.13 μM and 4.65 μM, respectively .

HY-P11211

D2A21	Antibiotic Bacterial	Infection
D2A21, a cecropin peptide, demonstrates a minimum cidal concentration of 21.69 μg/mL against Chlamydia trachomatis .

HY-160873

Firefly luciferase-IN-5	Fluorescent Dye	Others
Firefly luciferase-IN-5 (CID: 16031203) is an inhibitor of ATP-dependent luciferase (Firefly luciferase). It has nM-level inhibitory activity against GRLuc, RLuc8, and RLuc respectively (pIC₅₀=8.5,7.5,5.5) .

HY-128000

ML095 CID-25067483	Phosphatase	Others
ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP .

HY-16698

kb-NB77-78	PKD	Cancer
kb-NB77-78 is an analogue of CID797718, but shows no PKD inhibitory activity .

HY-158257

Firefly luciferase-IN-4	Fluorescent Dye	Others
Firefly luciferase-IN-4 (CID: 3987260) is an inhibitor of ATP-dependent luciferase (Firefly luciferase). It has nM-level inhibitory activity (pIC< sub>50=6.5) .

HY-12243

CID-797718	PKD	Others
CID-797718 is a compound with ambiguous properties.

HY-120126

ML378 CID71710938; JJH-254	Phospholipase	Metabolic Disease
ML378 (CID71710938) is a dual LYPLA1 and LYPLA2 inhibitor, with IC₅₀s of 122 nM and 245 nM respectively. ML378 also shows potent inhibition of ABHD6 (IC₅₀ = 3.15 nM). ML378 can be used for elucidating the patho/physiological roles of the LYPLA1 and LYPLA2 .

HY-16697R

CID 16020046 (Standard)	GPR55	Cancer
CID 16020046 (Standard) is the analytical standard of CID 16020046. This product is intended for research and analytical applications. CID 16020046 is a potent and selective GPR55 antagonist and inhibits GPR55 constitutive activity with an IC50 of 0.15 μM. CID 16020046 inhibits GPR55-mediated Ca2+ signaling and GPR55-mediated ERK1/2 phosphorylation. CID 16020046 reduces wound healing in endothelial cells and is involved in the regulation of platelet function .

HY-121085

CID-663143	Microtubule/Tubulin	Cancer
CID-663143 targets microtubule-associated proteins, not tubulin itself, to inhibit the polymerization process within cells. CID-663143 inhibits cancer cell growth (IC₅₀: <100 nM for HT-1080, BJeLR, MCF10A cells) .

HY-129338

CID 7309015	ROR	Inflammation/Immunology
CID 7309015 is an inhibitor of retinoic acid-related orphan receptor gamma (ROR-γ). CID 7309015 can be used for research of inflammation, NF-κB signaling or inflammatory arthritis .

HY-171261

CID15997213	Virus Protease	Infection
CID15997213 is a blood-brain barrier penetrating antiviral agent. CID15997213 targets the amino-terminal domain of the VEEV nonstructural protein 2 (nsP2). CID15997213 shows alphavirus-specific antiviral effect, inhibiting VEEV and Western equine encephalitis virus .

HY-123302

CID1172084	GPR55	Neurological Disease
CID1172084 (compound 3) is a selective GPR55 agonist (EC₅₀=0.16 μM). CID1172084 is more than 100-fold selective for GPR55 over GPR35, CB1, and CB2. CID1172084 can be used to further explore the biological functions and signaling pathways of the GPR55 receptor .

HY-116251

CID21480113	Bacterial	Infection
CID21480113 is an inhibitor of dapsone-resistant leprosy .

HY-16346R

Netupitant (Standard) CID 6451149 (Standard)	Reference Standards Neurokinin Receptor	Neurological Disease Endocrinology
Netupitant (Standard) is the analytical standard of Netupitant. This product is intended for research and analytical applications. Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK₁) receptor antagonist with a K_i of 0.95 nM for hNK₁ in CHO cells. Netupitant has antiemetic affect .

Cat. No.	Product Name	Target	Research Area

HY-P11211

D2A21	Antibiotic Bacterial	Infection
D2A21, a cecropin peptide, demonstrates a minimum cidal concentration of 21.69 μg/mL against Chlamydia trachomatis .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991913

CID-103 TSK011010	CD38	Cardiovascular Disease Inflammation/Immunology
CID-103 (TSK011010) is an anti-CD38 antibody that recognizes a unique epitope on CD38. CID-103 can be used in research on immune thrombocytopenia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3125

Osajin CID 95168; NSC 21565	Cardiovascular Disease Classification of Application Fields Metabolic Disease Plants Moraceae Flavonoids Phenols Polyphenols Maclura pomifera (Raf.) Schneid. Disease Research Fields Inflammation/Immunology Isoflavones Source Classification	Apoptosis
Osajin is the major bioactive isoflavone present in the fruit of Maclura pomifera with antitumor, antioxidant and anti-inflammatory activities.

Cat. No.	Product Name	Chemical Structure

HY-16346S

Netupitant-d6
Netupitant-d₆ is the deuterium labeled Netupitant (CID-6451149), which is a highly potent and selective, orally active neurokinin-1 (NK1) receptor antagonist .

HY-W720214

1,3-Dichlorobenzene-d4
1,3-Dichlorobenzene-d₄ (Benzene, m-dichloro- (8CI)-d₄; 2,4-Dichlorobenzene-d₄) is the deuterium labeled 1,3-Dichlorobenzene.

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