1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis

ML216 (Synonyms: CID-49852229)

Cat. No.: HY-12342 Purity: 97.92%
Handling Instructions

ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively.

For research use only. We do not sell to patients.

ML216 Chemical Structure

ML216 Chemical Structure

CAS No. : 1430213-30-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
5 mg USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 114 In-stock
Estimated Time of Arrival: December 31
25 mg USD 228 In-stock
Estimated Time of Arrival: December 31
50 mg USD 336 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ML216(CID-49852229) is a potent inhibitor of the DNA unwinding activity of BLM helicase; showing similar IC50s of 3.0 and 0.97 μM for full length BLM and BLM636–1298 respectively. IC50 value: 3.0/0.97 uM(Full length/636–1298 BLM) Target: BLM helicase inhibitor ML216 shows cell-based activity, and can induce sister chromatid exchanges, enhance to the toxicity of aphidicolin and exert anti-proliferative activity in cells expressing BLM, but not in those lacking BLM.

Solvent & Solubility
In Vitro: 

DMSO : 1.71 mg/mL (4.46 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6088 mL 13.0439 mL 26.0879 mL
5 mM 0.5218 mL 2.6088 mL 5.2176 mL
10 mM 0.2609 mL 1.3044 mL 2.6088 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

383.32

Formula

C₁₅H₉F₄N₅OS

CAS No.

1430213-30-1

SMILES

O=C(NC1=CC=C(F)C(C(F)(F)F)=C1)NC2=NN=C(S2)C3=CC=NC=C3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
ML216
Cat. No.:
HY-12342
Quantity:

ML216

Cat. No.: HY-12342