CID-50930756
CID-50930756 is an HCV NS3 helicase inhibitor with an IC50 of 22 μM.CID-50930756 inhibits HCV NS3 helicase-catalyzed nucleic acid unwinding.CID-50930756 inhibits HCV replication in hepatoma cells harboring a stably transfected subgenomic HCV replicon.CID-50930756 does not exhibit toxicity to hepatoma cells at 10 μM.CID-50930756 shows weak DNA-binding activity, displacing less than 20% of SYBR Green I from DNA at 100 μM.CID-50930756 can be used for the research of hepatitis c.
For research use only. We do not sell to patients.
- CAS No.: 1363454-18-5
- Formula: C27H18N4O4S3
- Molecular Weight:558.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
Description
IC50 & Target
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Helicase |
In Vitro
CID-50930756 (Compound 31) (100 μM) exhibits weak DNA-binding activity, displacing 15% of SYBR Green I bound to DNA at a concentration of 100 μM[1].
CID-50930756 (10 μM; 72 h) inhibits the replication of HCV genotype 1b subgenomic replicons in Huh7.5 cells, with an inhibition rate of 51% after treatment with 10 μM for 72 h, and no cytotoxicity is observed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1363454-18-5
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Molecular Weight 558.65
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Formula C27H18N4O4S3
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SMILES
O=C(NC1=CC=C(C=C1)C2=NC3=CC=C(C=C3S2)C4=NC=5C=CC(=C(C5S4)S(=O)(=O)O)C)C=6C=NC=CC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Liver Cancer Modeling
Liver cancer can be classified into primary liver cancer and secondary liver cancer. Secondary liver cancer is the metastatic liver cancer. Primary liver cancer includes hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and fibrolamellar HCC, of which HCC is the most common form, accounting for approximately 90% of primary liver cancers[1]. HCC mouse models include chemical agent-induced models, transplanted tumor models, and genetic engineered models.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CID-50930756 Related Classifications
HY-117802 Related Classifications
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