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Cat. No.: HY-117802

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CID-50930756

CID-50930756 is an HCV NS3 helicase inhibitor with an IC₅₀ of 22 μM.CID-50930756 inhibits HCV NS3 helicase-catalyzed nucleic acid unwinding.CID-50930756 inhibits HCV replication in hepatoma cells harboring a stably transfected subgenomic HCV replicon.CID-50930756 does not exhibit toxicity to hepatoma cells at 10 μM.CID-50930756 shows weak DNA-binding activity, displacing less than 20% of SYBR Green I from DNA at 100 μM.CID-50930756 can be used for the research of hepatitis c.

For research use only. We do not sell to patients.

CAS No.: 1363454-18-5
Formula: C₂₇H₁₈N₄O₄S₃
Molecular Weight:558.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CID-50930756 Chemical Structure

CAS No.: 1363454-18-5

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Calculators
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Bioz

Biological Activity

Description

IC₅₀ & Target

Helicase

All DNA/RNA Synthesis Isoforms :

In Vitro

CID-50930756 (Compound 31) (100 μM) exhibits weak DNA-binding activity, displacing 15% of SYBR Green I bound to DNA at a concentration of 100 μM^[1].
CID-50930756 (10 μM; 72 h) inhibits the replication of HCV genotype 1b subgenomic replicons in Huh7.5 cells, with an inhibition rate of 51% after treatment with 10 μM for 72 h, and no cytotoxicity is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1363454-18-5
Molecular Weight 558.65
Formula C₂₇H₁₈N₄O₄S₃
SMILES

O=C(NC1=CC=C(C=C1)C2=NC3=CC=C(C=C3S2)C4=NC=5C=CC(=C(C5S4)S(=O)(=O)O)C)C=6C=NC=CC6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li K, et al. Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline. J Med Chem. 2012;55(7):3319-3330. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CID-50930756

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CID-50930756 Related Classifications

HY-117802 Related Classifications