1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML 297

ML 297 (Synonyms: VU 0456810; CID 56642816)

Cat. No.: HY-110192 Purity: 98.85%
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ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy.

For research use only. We do not sell to patients.

ML 297 Chemical Structure

ML 297 Chemical Structure

CAS No. : 1443246-62-5

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10 mM * 1  mL in DMSO USD 325 Ask For Quote & Lead Time
5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 750 Ask For Quote & Lead Time

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ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].

IC50 & Target

EC50: 0.16 μM (GIRK1/2), 18 μM (GIRK1/4)[1]

In Vitro

ML 297 is completely inactive for GIRK2/3[1].
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM[2].
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3[2].

In Vivo

ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment[2].

Animal Model: 8-10 months old C57/BL6 male mice (approximately 30 g)[2]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection
Result: Most of the animals neither convulsions nor death.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
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ML 297VU 0456810CID 56642816ML297ML-297VU0456810VU-0456810CID56642816CID-56642816Potassium ChannelKcsAGIRKGIRK1/2epilepsyconvulsionsInhibitorinhibitorinhibit

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