1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML 297

ML 297 (Synonyms: VU 0456810; CID 56642816)

Cat. No.: HY-110192 Purity: 98.85%
Handling Instructions

ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy.

For research use only. We do not sell to patients.

ML 297 Chemical Structure

ML 297 Chemical Structure

CAS No. : 1443246-62-5

Size Price Stock
10 mM * 1  mL in DMSO USD 325 Ask For Quote & Lead Time
5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 750 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy[1][2].

IC50 & Target

EC50: 0.16 μM (GIRK1/2), 18 μM (GIRK1/4)[1]

In Vitro

ML 297 is completely inactive for GIRK2/3[1].
ML297 shows concentration-dependent efficacy in expressing GIRK1/2 cells and with an EC50 of 162 nM[2].
ML297 shows a complete inability to modulate the activity of HEK-293 cells expressing GIRK2 alone and GIRKGIRK2/3[2].

In Vivo

ML297 (60 mg/kg; i.p.) shows a highly significant ability to both prevent convulsions and prevent fatality of the PTZ treatment[2].

Animal Model: 8-10 months old C57/BL6 male mice (approximately 30 g)[2]
Dosage: 60 mg/kg
Administration: Intraperitoneal injection
Result: Most of the animals neither convulsions nor death.
Molecular Weight

328.32

Formula

C₁₇H₁₄F₂N₄O

CAS No.

1443246-62-5

SMILES

FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

ML 297VU 0456810CID 56642816ML297ML-297VU0456810VU-0456810CID56642816CID-56642816Potassium ChannelKcsAGIRKGIRK1/2epilepsyconvulsionsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ML 297
Cat. No.:
HY-110192
Quantity:
MCE Japan Authorized Agent: