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Cat. No.: HY-110192R

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ML 297 (Standard)

Name: ML 297 (Standard)
Brand: MedChemExpress
SKU: HY-110192R
Availability: PreOrder

(Synonyms: VU 0456810 (Standard); CID 56642816 (Standard))

ML 297 (Standard) is the analytical standard of ML 297 (HY-110192). This product is intended for research and analytical applications. ML 297 (VU 0456810) is a potent and selective GIRK1/2 activator, with an EC₅₀ of 0.16 μM. ML 297 can cross the blood-brain barrier with brain-to-plasma ratio of 0.2 in mice model (i.p.). ML 297 is potential for the treatment of epilepsy.

For research use only. We do not sell to patients.

CAS No.: 1443246-62-5
Formula: C₁₇H₁₄F₂N₄O
Molecular Weight:328.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

ML 297 (Standard) Chemical Structure

CAS No.: 1443246-62-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1443246-62-5
Molecular Weight 328.32
Formula C₁₇H₁₄F₂N₄O
SMILES

FC1=C(F)C=CC(NC(NC2=CC(C)=NN2C3=CC=CC=C3)=O)=C1
Synonyms

VU 0456810 (Standard); CID 56642816 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6. [Content Brief]

[2]. Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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