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  3. CID44216842

CID44216842 (Synonyms: Cdc42-IN-1)

Cat. No.: HY-136379 Purity: 99.84%
Handling Instructions

CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.

For research use only. We do not sell to patients.

CID44216842 Chemical Structure

CID44216842 Chemical Structure

CAS No. : 1222513-26-9

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Estimated Time of Arrival: December 31
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Description

CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe[1].

IC50 & Target

EC50: 1.0 μM (Cdc42 WT, in GTP binding assay) and 1.2 μM (Cdc42Q61L mutant, in GTP binding assay)[1]
EC50: 0.3 μM (Cdc42 WT, in GDP binding assay) and 0.5 μM (Cdc42Q61L mutant, in GDP binding assay)[1]

In Vitro

CID44216842 inhibits GTP binding to both Cdc42 and its mutant in a dose-dependent manner. The inhibition is specific toward Cdc42 with no effects on other GTPases including Rac and Rho in the same family[1].

Molecular Weight

486.38

Formula

C₂₂H₂₀BrN₃O₃S

CAS No.

1222513-26-9

SMILES

O=S(C1=CC=C(N2N=C(C3=CC=CC(OC)=C3)CC2C4=CC=C(Br)C=C4)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

CID44216842Cdc42-IN-1CID 44216842CID-44216842RasCdc42cancerimmunediseasesneurologicaldisordersovarianbreasthepatitis Cvirusmentalretardationneutrophilsfibroblastskidney epitheliaInhibitorinhibitorinhibit

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CID44216842
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HY-136379
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